| Identification |
|---|
| HMDB Protein ID
| HMDBP12149 |
| Secondary Accession Numbers
| None |
| Name
| Serine-aspartate repeat-containing protein G |
| Synonyms
|
Not Available
|
| Gene Name
| SDRG |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Binds to the N-terminus of the B beta-chain of human fibrinogen and thereby interferes with thrombin cleavage and release of fibrinopeptide B, thus interfering with fibrin clot formation. This may hinder host defense against microbial infections. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cell adhesion |
| pathogenesis |
| Cellular Component |
| extracellular region |
| cell wall |
| Molecular Function |
| metal ion binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 102954.97 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9KI13 |
| UniProtKB/Swiss-Prot Entry Name
| SDRG_STAEP |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - McCrea KW, Hartford O, Davis S, Eidhin DN, Lina G, Speziale P, Foster TJ, Hook M: The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidermidis. Microbiology (Reading). 2000 Jul;146 ( Pt 7):1535-1546. doi: 10.1099/00221287-146-7-1535. [PubMed:10878118 ]
- Davis SL, Gurusiddappa S, McCrea KW, Perkins S, Hook M: SdrG, a fibrinogen-binding bacterial adhesin of the microbial surface components recognizing adhesive matrix molecules subfamily from Staphylococcus epidermidis, targets the thrombin cleavage site in the Bbeta chain. J Biol Chem. 2001 Jul 27;276(30):27799-805. doi: 10.1074/jbc.M103873200. Epub 2001 May 22. [PubMed:11371571 ]
- Ponnuraj K, Bowden MG, Davis S, Gurusiddappa S, Moore D, Choe D, Xu Y, Hook M, Narayana SV: A "dock, lock, and latch" structural model for a staphylococcal adhesin binding to fibrinogen. Cell. 2003 Oct 17;115(2):217-28. doi: 10.1016/s0092-8674(03)00809-2. [PubMed:14567919 ]
|
