| Identification |
|---|
| HMDB Protein ID
| HMDBP12146 |
| Secondary Accession Numbers
| None |
| Name
| Lipase 1 |
| Synonyms
|
- GCL I
- Lipase I
|
| Gene Name
| LIP1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Hydrolyzes all ester bonds in triglyceride and displays a high affinity for triolein. For unsaturated substrates having long fatty acyl chains (C18:2 cis-9, cis-12 and C18:3 cis-9, cis-12, cis-15) GCL I shows higher specific activity than GCL II, whereas GCL II shows higher specific activity against saturated substrates having short fatty acid chains (C8, C10, C12 and C14). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| lipid catabolic process |
| Cellular Component |
| extracellular region |
| Molecular Function |
| triglyceride lipase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 61198.54 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P17573 |
| UniProtKB/Swiss-Prot Entry Name
| LIP1_GEOCN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Shimada Y, Sugihara A, Tominaga Y, Iizumi T, Tsunasawa S: cDNA molecular cloning of Geotrichum candidum lipase. J Biochem. 1989 Sep;106(3):383-8. doi: 10.1093/oxfordjournals.jbchem.a122862. [PubMed:2481674 ]
- Bertolini MC, Laramee L, Thomas DY, Cygler M, Schrag JD, Vernet T: Polymorphism in the lipase genes of Geotrichum candidum strains. Eur J Biochem. 1994 Jan 15;219(1-2):119-25. doi: 10.1111/j.1432-1033.1994.tb19921.x. [PubMed:8306978 ]
- Nagao T, Shimada Y, Sugihara A, Tominaga Y: Cloning and sequencing of two chromosomal lipase genes from Geotrichum candidum. J Biochem. 1993 Jun;113(6):776-80. doi: 10.1093/oxfordjournals.jbchem.a124117. [PubMed:8370674 ]
- Slabas AR, Windust J, Sidebottom CM: Does sequence similarity of human choline esterase, Torpedo acetylcholine esterase and Geotrichum candidum lipase reveal the active site serine residue? Biochem J. 1990 Jul 1;269(1):279-80. doi: 10.1042/bj2690279. [PubMed:2115773 ]
- Bertolini MC, Schrag JD, Cygler M, Ziomek E, Thomas DY, Vernet T: Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II. Eur J Biochem. 1995 Mar 15;228(3):863-9. [PubMed:7737187 ]
|
