| Identification |
|---|
| HMDB Protein ID
| HMDBP12144 |
| Secondary Accession Numbers
| None |
| Name
| Phospholipase C |
| Synonyms
|
- PLC
- Alpha-toxin
- Hemolysin
- Lecithinase
- Phosphatidylcholine cholinephosphohydrolase
|
| Gene Name
| PLC |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes. |
| Pathways
|
- Biosynthesis of secondary metabolites
- Glycerophospholipid metabolism
- Inositol phosphate metabolism
- Quorum sensing
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| hemolysis in other organism |
| Cellular Component |
| extracellular region |
| Molecular Function |
| zinc ion binding |
| hydrolase activity |
| phosphatidylcholine phospholipase C activity |
| toxin activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 398 |
| Molecular Weight
| 45475.235 |
| Theoretical pI
| 6.033 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q0TV31 |
| UniProtKB/Swiss-Prot Entry Name
| PHLC_CLOP1 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Okabe A, Shimizu T, Hayashi H: Cloning and sequencing of a phospholipase C gene of Clostridium perfringens. Biochem Biophys Res Commun. 1989 Apr 14;160(1):33-9. doi: 10.1016/0006-291x(89)91616-1. [PubMed:2540749 ]
- Titball RW, Hunter SE, Martin KL, Morris BC, Shuttleworth AD, Rubidge T, Anderson DW, Kelly DC: Molecular cloning and nucleotide sequence of the alpha-toxin (phospholipase C) of Clostridium perfringens. Infect Immun. 1989 Feb;57(2):367-76. doi: 10.1128/iai.57.2.367-376.1989. [PubMed:2536355 ]
- Tso JY, Siebel C: Cloning and expression of the phospholipase C gene from Clostridium perfringens and Clostridium bifermentans. Infect Immun. 1989 Feb;57(2):468-76. doi: 10.1128/iai.57.2.468-476.1989. [PubMed:2536356 ]
|
