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Showing Protein Protein kinase C gamma type (HMDBP12143)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12143
Secondary Accession Numbers None
Name Protein kinase C gamma type
Synonyms
  1. PKC-gamma
Gene Name PRKCG
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock.
Pathways
  • African trypanosomiasis
  • Aldosterone synthesis and secretion
  • Aldosterone-regulated sodium reabsorption
  • Amoebiasis
  • Amphetamine addiction
  • Calcium signaling pathway
  • Chemical carcinogenesis - receptor activation
  • Choline metabolism in cancer
  • Cholinergic synapse
  • Circadian entrainment
  • Coronavirus disease - COVID-19
  • Diabetic cardiomyopathy
  • Dopaminergic synapse
  • EGFR tyrosine kinase inhibitor resistance
  • Endocrine and other factor-regulated calcium reabsorption
  • ErbB signaling pathway
  • Fc gamma R-mediated phagocytosis
  • Focal adhesion
  • GABAergic synapse
  • Gap junction
  • Gastric acid secretion
  • Glioma
  • Glutamatergic synapse
  • GnRH secretion
  • Growth hormone synthesis, secretion and action
  • Hepatitis B
  • Hepatocellular carcinoma
  • HIF-1 signaling pathway
  • Human cytomegalovirus infection
  • Human immunodeficiency virus 1 infection
  • Inflammatory mediator regulation of TRP channels
  • Insulin secretion
  • Leukocyte transendothelial migration
  • Long-term depression
  • Long-term potentiation
  • MAPK signaling pathway
  • Melanogenesis
  • MicroRNAs in cancer
  • Morphine addiction
  • mTOR signaling pathway
  • Natural killer cell mediated cytotoxicity
  • Neutrophil extracellular trap formation
  • Non-small cell lung cancer
  • Oxytocin signaling pathway
  • Pancreatic secretion
  • Parathyroid hormone synthesis, secretion and action
  • Pathways of neurodegeneration - multiple diseases
  • Phosphatidylinositol signaling system
  • Proteoglycans in cancer
  • Rap1 signaling pathway
  • Ras signaling pathway
  • Retrograde endocannabinoid signaling
  • Salivary secretion
  • Serotonergic synapse
  • Sphingolipid signaling pathway
  • Spinocerebellar ataxia
  • Thyroid hormone signaling pathway
  • Thyroid hormone synthesis
  • Vascular smooth muscle contraction
  • VEGF signaling pathway
  • Wnt signaling pathway
Reactions Not Available
GO Classification
Biological Process
negative regulation of neuron apoptotic process
rhythmic process
regulation of response to food
regulation of circadian rhythm
negative regulation of proteasomal protein catabolic process
peptidyl-serine phosphorylation
negative regulation of protein ubiquitination
response to pain
intracellular signal transduction
response to morphine
Cellular Component
synapse
cytosol
perinuclear region of cytoplasm
dendrite
plasma membrane
Molecular Function
calcium-dependent protein kinase C activity
protein serine kinase activity
protein serine/threonine kinase activity
protein threonine kinase activity
zinc ion binding
ATP binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 682
Molecular Weight 77155.705
Theoretical pI 7.672
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P05128
UniProtKB/Swiss-Prot Entry Name KPCG_BOVIN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A: Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science. 1986 Aug 22;233(4766):859-66. [PubMed:3755548 ]
  2. Nishizuka Y: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988 Aug 25;334(6184):661-5. doi: 10.1038/334661a0. [PubMed:3045562 ]