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Showing Protein Protein kinase C beta type (HMDBP12134)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12134
Secondary Accession Numbers None
Name Protein kinase C beta type
Synonyms
  1. PKC-B
  2. PKC-beta
Gene Name PRKCB
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity).
Pathways
  • African trypanosomiasis
  • AGE-RAGE signaling pathway in diabetic complications
  • Aldosterone synthesis and secretion
  • Aldosterone-regulated sodium reabsorption
  • Amoebiasis
  • Amphetamine addiction
  • B cell receptor signaling pathway
  • Calcium signaling pathway
  • Carbohydrate digestion and absorption
  • Chemical carcinogenesis - receptor activation
  • Chemokine signaling pathway
  • Choline metabolism in cancer
  • Cholinergic synapse
  • Circadian entrainment
  • Coronavirus disease - COVID-19
  • Diabetic cardiomyopathy
  • Dopaminergic synapse
  • EGFR tyrosine kinase inhibitor resistance
  • Endocrine and other factor-regulated calcium reabsorption
  • ErbB signaling pathway
  • Fc gamma R-mediated phagocytosis
  • Focal adhesion
  • GABAergic synapse
  • Gap junction
  • Gastric acid secretion
  • Glioma
  • Glutamatergic synapse
  • GnRH secretion
  • GnRH signaling pathway
  • Growth hormone synthesis, secretion and action
  • Hepatitis B
  • Hepatocellular carcinoma
  • HIF-1 signaling pathway
  • Human cytomegalovirus infection
  • Human immunodeficiency virus 1 infection
  • Inflammatory mediator regulation of TRP channels
  • Influenza A
  • Insulin resistance
  • Insulin secretion
  • Leishmaniasis
  • Leukocyte transendothelial migration
  • Long-term depression
  • Long-term potentiation
  • MAPK signaling pathway
  • Melanogenesis
  • MicroRNAs in cancer
  • Morphine addiction
  • mTOR signaling pathway
  • Natural killer cell mediated cytotoxicity
  • Neutrophil extracellular trap formation
  • NF-kappa B signaling pathway
  • Non-small cell lung cancer
  • Oxytocin signaling pathway
  • Pancreatic secretion
  • Parathyroid hormone synthesis, secretion and action
  • Pathways of neurodegeneration - multiple diseases
  • Phosphatidylinositol signaling system
  • Proteoglycans in cancer
  • Rap1 signaling pathway
  • Ras signaling pathway
  • Retrograde endocannabinoid signaling
  • Salivary secretion
  • Serotonergic synapse
  • Sphingolipid signaling pathway
  • Spinocerebellar ataxia
  • Thyroid hormone signaling pathway
  • Thyroid hormone synthesis
  • Vascular smooth muscle contraction
  • VEGF signaling pathway
  • Wnt signaling pathway
Reactions Not Available
GO Classification
Biological Process
negative regulation of glucose transport
regulation of synaptic vesicle exocytosis
presynaptic modulation of chemical synaptic transmission
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of B cell receptor signaling pathway
histone H3-T6 phosphorylation
cellular response to carbohydrate stimulus
B cell activation
adaptive immune response
peptidyl-serine phosphorylation
regulation of glucose transport
negative regulation of insulin receptor signaling pathway
calcium ion transport
regulation of transcription from RNA polymerase II promoter
B cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
positive regulation of angiogenesis
intracellular signal transduction
positive regulation of I-kappaB kinase/NF-kappaB cascade
apoptotic process
cellular calcium ion homeostasis
Cellular Component
nucleus
nucleoplasm
spectrin
plasma membrane
calyx of Held
presynaptic cytosol
Molecular Function
protein threonine kinase activity
androgen receptor binding
ATP binding
zinc ion binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin binding
histone binding
protein serine/threonine kinase activity
protein serine kinase activity
protein kinase C binding
protein kinase C activity
histone kinase activity (H3-T6 specific)
calcium-dependent protein kinase C activity
calcium channel regulator activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 671
Molecular Weight 76789.41
Theoretical pI 7.002
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P05126
UniProtKB/Swiss-Prot Entry Name KPCB_BOVIN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A: Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science. 1986 Aug 22;233(4766):859-66. [PubMed:3755548 ]
  2. Nishizuka Y: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988 Aug 25;334(6184):661-5. doi: 10.1038/334661a0. [PubMed:3045562 ]