Hmdb loader
Identification
HMDB Protein ID HMDBP12133
Secondary Accession Numbers None
Name Diacylglycerol kinase theta
Synonyms
  1. DAG kinase theta
  2. DGKtheta
Gene Name DGKQ
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15337525). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15337525). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (PubMed:15337525). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (By similarity).
Pathways
  • Choline metabolism in cancer
  • Glycerolipid metabolism
  • Glycerophospholipid metabolism
  • Phosphatidylinositol signaling system
  • Phospholipase D signaling pathway
Reactions Not Available
GO Classification
Biological Process
peptidyl-serine phosphorylation
regulation of transcription from RNA polymerase II promoter
diacylglycerol metabolic process
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of gene expression
thrombin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of peptidyl-threonine phosphorylation
glycerolipid metabolic process
lipid phosphorylation
protein kinase C signaling
regulation of cortisol biosynthetic process
regulation of progesterone biosynthetic process
regulation of synaptic vesicle endocytosis
regulation of TORC1 signaling
response to ATP
phosphatidic acid biosynthetic process
regulation of cholesterol metabolic process
regulation of gluconeogenesis
intracellular signal transduction
cAMP-mediated signaling
response to cAMP
positive regulation of gene expression
Cellular Component
glutamatergic synapse
cytoplasm
plasma membrane
nucleus
presynapse
postsynapse
nuclear matrix
nuclear speck
vesicle membrane
endosome
cytosol
cytoskeleton
Molecular Function
diacylglycerol kinase activity
kinase binding
activating transcription factor binding
phospholipase binding
transmembrane receptor protein tyrosine kinase activator activity
ATP binding
NAD+ kinase activity
metal ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 937
Molecular Weight 102544.59
Theoretical pI 7.295
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID D3ZEY4
UniProtKB/Swiss-Prot Entry Name DGKQ_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Alba M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hubner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, Lopez-Otin C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F: Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004 Apr 1;428(6982):493-521. doi: 10.1038/nature02426. [PubMed:15057822 ]
  2. Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871. [PubMed:22673903 ]
  3. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ: Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. J Biol Chem. 1997 Apr 18;272(16):10422-8. doi: 10.1074/jbc.272.16.10422. [PubMed:9099683 ]
  4. Tabellini G, Billi AM, Fala F, Cappellini A, Evagelisti C, Manzoli L, Cocco L, Martelli AM: Nuclear diacylglycerol kinase-theta is activated in response to nerve growth factor stimulation of PC12 cells. Cell Signal. 2004 Nov;16(11):1263-71. doi: 10.1016/j.cellsig.2004.03.018. [PubMed:15337525 ]