| Identification |
|---|
| HMDB Protein ID
| HMDBP12129 |
| Secondary Accession Numbers
| None |
| Name
| RAS guanyl-releasing protein 4 |
| Synonyms
|
Not Available
|
| Gene Name
| RASGRP4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. |
| Pathways
|
- MAPK signaling pathway
- Ras signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cell differentiation |
| cell proliferation |
| small GTPase mediated signal transduction |
| positive regulation of Ras protein signal transduction |
| response to extracellular stimulus |
| Cellular Component |
| cytoplasm |
| plasma membrane |
| membrane |
| Molecular Function |
| calcium ion binding |
| guanyl-nucleotide exchange factor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 678 |
| Molecular Weight
| 75404.435 |
| Theoretical pI
| 8.158 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8R5I4 |
| UniProtKB/Swiss-Prot Entry Name
| GRP4_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Li L, Yang Y, Stevens RL: RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. J Biol Chem. 2003 Feb 14;278(7):4725-9. Epub 2002 Dec 18. [PubMed:12493770 ]
- Li L, Yang Y, Stevens RL: Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors. Mol Immunol. 2002 Sep;38(16-18):1283-8. doi: 10.1016/s0161-5890(02)00076-7. [PubMed:12217396 ]
|
