| Identification |
|---|
| HMDB Protein ID
| HMDBP12126 |
| Secondary Accession Numbers
| None |
| Name
| Diacylglycerol O-acyltransferase 1 |
| Synonyms
|
- Acyl-CoA retinol O-fatty-acyltransferase
- Diglyceride acyltransferase
- ARAT
- Retinol O-fatty-acyltransferase
|
| Gene Name
| DGAT1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (By similarity). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (By similarity). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). |
| Pathways
|
- Fat digestion and absorption
- Glycerolipid metabolism
- Retinol metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of fatty acid oxidation |
| response to human chorionic gonadotropin |
| regulation of vitamin A metabolic process |
| regulation of intestinal lipid absorption |
| regulation of eating behavior |
| ketone body metabolic process |
| monoacylglycerol biosynthetic process |
| glycerolipid metabolic process |
| positive regulation of hepatic stellate cell activation |
| insulin secretion |
| diacylglycerol metabolic process |
| lipid storage |
| fatty acid homeostasis |
| triglyceride biosynthetic process |
| positive regulation of triglyceride biosynthetic process |
| very-low-density lipoprotein particle assembly |
| long-chain fatty-acyl-CoA metabolic process |
| Cellular Component |
| intracellular membrane-bounded organelle |
| endoplasmic reticulum membrane |
| plasma membrane |
| membrane |
| integral to membrane |
| Molecular Function |
| O-acyltransferase activity |
| fatty acid binding |
| transferase activity, transferring acyl groups |
| identical protein binding |
| diacylglycerol O-acyltransferase activity |
| 2-acylglycerol O-acyltransferase activity |
| diacylglycerol binding |
| retinol O-fatty-acyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 498 |
| Molecular Weight
| 56869.665 |
| Theoretical pI
| 9.414 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 93-127;140-165;171-193;201-232;285-319;327-364;411-431;440-458;461-492;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9ERM3 |
| UniProtKB/Swiss-Prot Entry Name
| DGAT1_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
