Hmdb loader
Identification
HMDB Protein ID HMDBP12099
Secondary Accession Numbers None
Name Phosphatidylinositol:ceramide inositolphosphotransferase
Synonyms
  1. LmjIPCS
  2. Inositol-phosphorylceramide synthase
  3. Sphingolipid synthase
  4. IPC synthase
Gene Name IPCS
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target.
Pathways
  • sphingolipid metabolism
Reactions Not Available
GO Classification
Biological Process
ceramide biosynthetic process
ethanolamine biosynthetic process
Cellular Component
integral to Golgi membrane
integral to plasma membrane
integral to endoplasmic reticulum membrane
Golgi apparatus
endosome
ciliary pocket
Molecular Function
kinase activity
ceramide cholinephosphotransferase activity
sphingomyelin synthase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 338
Molecular Weight 37644.105
Theoretical pI 6.652
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 37-57;88-108;117-137;153-173;190-210;223-243;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID E9AFX2
UniProtKB/Swiss-Prot Entry Name SLS_LEIMA
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Sevova ES, Goren MA, Schwartz KJ, Hsu FF, Turk J, Fox BG, Bangs JD: Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic trypanosomatid protozoa. J Biol Chem. 2010 Jul 2;285(27):20580-7. doi: 10.1074/jbc.M110.127662. Epub 2010 May 10. [PubMed:20457606 ]
  2. Sutterwala SS, Hsu FF, Sevova ES, Schwartz KJ, Zhang K, Key P, Turk J, Beverley SM, Bangs JD: Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol Microbiol. 2008 Oct;70(2):281-96. doi: 10.1111/j.1365-2958.2008.06393.x. Epub 2008 Aug 11. [PubMed:18699867 ]
  3. Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E, Aert R, Anupama A, Apostolou Z, Attipoe P, Bason N, Bauser C, Beck A, Beverley SM, Bianchettin G, Borzym K, Bothe G, Bruschi CV, Collins M, Cadag E, Ciarloni L, Clayton C, Coulson RM, Cronin A, Cruz AK, Davies RM, De Gaudenzi J, Dobson DE, Duesterhoeft A, Fazelina G, Fosker N, Frasch AC, Fraser A, Fuchs M, Gabel C, Goble A, Goffeau A, Harris D, Hertz-Fowler C, Hilbert H, Horn D, Huang Y, Klages S, Knights A, Kube M, Larke N, Litvin L, Lord A, Louie T, Marra M, Masuy D, Matthews K, Michaeli S, Mottram JC, Muller-Auer S, Munden H, Nelson S, Norbertczak H, Oliver K, O'neil S, Pentony M, Pohl TM, Price C, Purnelle B, Quail MA, Rabbinowitsch E, Reinhardt R, Rieger M, Rinta J, Robben J, Robertson L, Ruiz JC, Rutter S, Saunders D, Schafer M, Schein J, Schwartz DC, Seeger K, Seyler A, Sharp S, Shin H, Sivam D, Squares R, Squares S, Tosato V, Vogt C, Volckaert G, Wambutt R, Warren T, Wedler H, Woodward J, Zhou S, Zimmermann W, Smith DF, Blackwell JM, Stuart KD, Barrell B, Myler PJ: The genome of the kinetoplastid parasite, Leishmania major. Science. 2005 Jul 15;309(5733):436-42. doi: 10.1126/science.1112680. [PubMed:16020728 ]