| Identification |
|---|
| HMDB Protein ID
| HMDBP12093 |
| Secondary Accession Numbers
| None |
| Name
| Phosphatidylethanolamine:ceramide ethanolaminephosphotransferase |
| Synonyms
|
- TbSLS2
- Ethanolamine-phosphorylceramide synthase
- Sphingolipid synthase
- EPC synthase
|
| Gene Name
| SLS2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bidirectional lipid ethanolaminephosphotransferase capable of converting phosphatidylethanolamine (PE) and ceramide to ethanolamine-phosphorylceramide (EPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoethanolamine acceptors. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| sphingolipid metabolic process |
| Cellular Component |
| integral to membrane |
| Molecular Function |
| kinase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 36514.91 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 27-47;75-95;148-168;188-208;234-254;258-278;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| B3A0M0 |
| UniProtKB/Swiss-Prot Entry Name
| SLS2_TRYBB |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sevova ES, Goren MA, Schwartz KJ, Hsu FF, Turk J, Fox BG, Bangs JD: Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic trypanosomatid protozoa. J Biol Chem. 2010 Jul 2;285(27):20580-7. doi: 10.1074/jbc.M110.127662. Epub 2010 May 10. [PubMed:20457606 ]
- Sutterwala SS, Hsu FF, Sevova ES, Schwartz KJ, Zhang K, Key P, Turk J, Beverley SM, Bangs JD: Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol Microbiol. 2008 Oct;70(2):281-96. doi: 10.1111/j.1365-2958.2008.06393.x. Epub 2008 Aug 11. [PubMed:18699867 ]
|
