| Identification |
|---|
| HMDB Protein ID
| HMDBP12091 |
| Secondary Accession Numbers
| None |
| Name
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
| Synonyms
|
- Phosphoinositide phospholipase C-zeta-1
- Phospholipase C-zeta-1
- PLC-zeta-1
|
| Gene Name
| PLCZ1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
| Pathways
|
- Calcium signaling pathway
- Inositol phosphate metabolism
- Oocyte meiosis
- Phosphatidylinositol signaling system
- Thyroid hormone signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| multicellular organismal development |
| intracellular signal transduction |
| calcium ion transport |
| lipid catabolic process |
| egg activation |
| Cellular Component |
| cytosol |
| nucleus |
| perinuclear region of cytoplasm |
| Molecular Function |
| calcium ion binding |
| phosphatidylinositol phospholipase C activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 640 |
| Molecular Weight
| 74550.91 |
| Theoretical pI
| 7.688 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q95JS1 |
| UniProtKB/Swiss-Prot Entry Name
| PLCZ1_MACFA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Cox LJ, Larman MG, Saunders CM, Hashimoto K, Swann K, Lai FA: Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes. Reproduction. 2002 Nov;124(5):611-23. [PubMed:12416999 ]
- Osada N, Hida M, Kusuda J, Tanuma R, Hirata M, Suto Y, Hirai M, Terao K, Sugano S, Hashimoto K: Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence. BMC Genomics. 2002 Dec 23;3(1):36. doi: 10.1186/1471-2164-3-36. Epub 2002 Dec 23. [PubMed:12498619 ]
|
