| Identification |
|---|
| HMDB Protein ID
| HMDBP12090 |
| Secondary Accession Numbers
| None |
| Name
| Phosphatidylinositol phosphate synthase |
| Synonyms
|
- PIP synthase
- CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase
|
| Gene Name
| (GENBANK) CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation. |
| Pathways
|
- Glycerophospholipid metabolism
- phosphatidylinositol phosphate biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| phospholipid biosynthetic process |
| Cellular Component |
| integral to plasma membrane |
| Molecular Function |
| magnesium ion binding |
| phosphotransferase activity, for other substituted phosphate groups |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 207 |
| Molecular Weight
| 22324.09 |
| Theoretical pI
| 8.386 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 21-44;50-67;88-106;112-131;152-170;176-195;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6A8U1 |
| UniProtKB/Swiss-Prot Entry Name
| PIPS_CUTAK |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Bruggemann H, Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, Hujer S, Durre P, Gottschalk G: The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science. 2004 Jul 30;305(5684):671-3. doi: 10.1126/science.1100330. [PubMed:15286373 ]
- Morii H, Ogawa M, Fukuda K, Taniguchi H: Ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in Bacteria and Archaea, which contain inositol phospholipid. Biochem Biophys Res Commun. 2014 Jan 3;443(1):86-90. doi: 10.1016/j.bbrc.2013.11.054. Epub 2013 Nov 20. [PubMed:24269814 ]
|
