| Identification |
|---|
| HMDB Protein ID
| HMDBP12086 |
| Secondary Accession Numbers
| None |
| Name
| Kit ligand |
| Synonyms
|
- Hematopoietic growth factor KL
- Mast cell growth factor
- Stem cell factor
- c-Kit ligand
- MGF
- SCF
|
| Gene Name
| KITLG |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Pathways
|
- Hematopoietic cell lineage
- MAPK signaling pathway
- Melanogenesis
- Phospholipase D signaling pathway
- PI3K-Akt signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| ovarian follicle development |
| positive regulation of myeloid leukocyte differentiation |
| positive regulation of melanocyte differentiation |
| positive regulation of mast cell proliferation |
| positive regulation of leukocyte migration |
| positive regulation of hematopoietic stem cell proliferation |
| neural crest cell migration |
| negative regulation of mast cell apoptotic process |
| extrinsic apoptotic signaling pathway in absence of ligand |
| ectopic germ cell programmed cell death |
| positive regulation of MAP kinase activity |
| positive regulation of peptidyl-tyrosine phosphorylation |
| embryonic hemopoiesis |
| positive regulation of Ras protein signal transduction |
| negative regulation of apoptotic process |
| male gonad development |
| cell adhesion |
| positive regulation of cell proliferation |
| Cellular Component |
| integral to membrane |
| filopodium |
| lamellipodium |
| cytoskeleton |
| extracellular space |
| plasma membrane |
| cytoplasm |
| Molecular Function |
| cytokine activity |
| stem cell factor receptor binding |
| growth factor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 273 |
| Molecular Weight
| 30712.01 |
| Theoretical pI
| 5.558 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P21581 |
| UniProtKB/Swiss-Prot Entry Name
| SCF_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Martin FH, Suggs SV, Langley KE, Lu HS, Ting J, Okino KH, Morris CF, McNiece IK, Jacobsen FW, Mendiaz EA, et al.: Primary structure and functional expression of rat and human stem cell factor DNAs. Cell. 1990 Oct 5;63(1):203-11. [PubMed:2208279 ]
- Lu HS, Clogston CL, Wypych J, Fausset PR, Lauren S, Mendiaz EA, Zsebo KM, Langley KE: Amino acid sequence and post-translational modification of stem cell factor isolated from buffalo rat liver cell-conditioned medium. J Biol Chem. 1991 May 5;266(13):8102-7. [PubMed:1708771 ]
- Zsebo KM, Wypych J, McNiece IK, Lu HS, Smith KA, Karkare SB, Sachdev RK, Yuschenkoff VN, Birkett NC, Williams LR, et al.: Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium. Cell. 1990 Oct 5;63(1):195-201. doi: 10.1016/0092-8674(90)90300-4. [PubMed:2208278 ]
|
