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Showing Protein Phosphatidylinositol:ceramide inositolphosphotransferase (HMDBP12085)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12085
Secondary Accession Numbers None
Name Phosphatidylinositol:ceramide inositolphosphotransferase
Synonyms
  1. Inositol-phosphorylceramide synthase
  2. Sphingolipid synthase
  3. IPC synthase
Gene Name SLS1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).
Pathways
  • sphingolipid metabolism
Reactions Not Available
GO Classification
Biological Process
ceramide biosynthetic process
sphingomyelin biosynthetic process
Cellular Component
integral to Golgi membrane
membrane
integral to plasma membrane
integral to endoplasmic reticulum membrane
Molecular Function
kinase activity
ceramide cholinephosphotransferase activity
sphingomyelin synthase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 355
Molecular Weight 39892.59
Theoretical pI 7.458
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 45-65;90-110;166-186;206-226;252-272;276-296;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q38E53
UniProtKB/Swiss-Prot Entry Name SLS1_TRYB2
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Bohme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM: The genome of the African trypanosome Trypanosoma brucei. Science. 2005 Jul 15;309(5733):416-22. doi: 10.1126/science.1112642. [PubMed:16020726 ]