| Identification |
|---|
| HMDB Protein ID
| HMDBP12074 |
| Secondary Accession Numbers
| None |
| Name
| Ketimine reductase mu-crystallin |
| Synonyms
|
- CDK108
- NADP-regulated thyroid-hormone-binding protein
|
| Gene Name
| CRYM |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). Major component of eye lens in marsupials. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| cytoplasm |
| Molecular Function |
| thiomorpholine-carboxylate dehydrogenase activity |
| structural constituent of eye lens |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 33930.595 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q28488 |
| UniProtKB/Swiss-Prot Entry Name
| CRYM_MACFL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Kim RY, Gasser R, Wistow GJ: mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9292-6. doi: 10.1073/pnas.89.19.9292. [PubMed:1384048 ]
|
