| Identification |
|---|
| HMDB Protein ID
| HMDBP11739 |
| Secondary Accession Numbers
| None |
| Name
| Galactoside 3(4)-L-fucosyltransferase |
| Synonyms
|
- Blood group Lewis alpha-4-fucosyltransferase
- Fucosyltransferase 3
- Fucosyltransferase III
- Lewis FT
- FucT-III
|
| Gene Name
| FUT3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.
|
| Pathways
|
- Glycosphingolipid biosynthesis - lacto and neolacto series
- protein glycosylation
|
| Reactions
|
| GDP-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R → Guanosine diphosphate + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R |
details
|
| GDP-L-fucose + Paragloboside → GDP + III3Fuc-nLc4Cer |
details
|
| GDP-L-fucose + nLc6Cer → GDP + V3Fuc-nLc6Cer |
details
|
| GDP-L-fucose + nLc8Cer → GDP + |
details
|
| GDP-L-fucose + Sialyl-3-paragloboside → GDP + IV3NeuAc,III3Fuc-nLc4Cer |
details
|
| GDP-L-fucose + VI2Fuc-nLc6 → GDP + |
details
|
| GDP-L-fucose + IV2Fuc-nLc4Cer → GDP + III3,IV2Fuc-nLc4Cer |
details
|
| GDP-L-fucose + Lc4Cer → GDP + Fuc-Lc4Cer |
details
|
| GDP-L-fucose + Type IA glycolipid → GDP + |
details
|
| GDP-L-fucose + IV2Fuc-Lc4Cer → GDP + IV2Fuc,III4Fuc-Lc4Cer |
details
|
| GDP-L-fucose + Type IB glycolipid → GDP + |
details
|
| GDP-L-fucose + 3'-isoLM1 → GDP + Fuc-3'-isoLM1 |
details
|
| GDP-L-fucose + V3Fuc-nLc6Cer → GDP + V3Fuc,III3Fuc-nLc6Cer |
details
|
| GDP-L-fucose + → GDP + |
details
|
| GDP-L-fucose + → GDP + |
details
|
| GDP-L-fucose + → GDP + |
details
|
| GDP-L-fucose + nLc6Cer → GDP + III3Fuc-nLc6Cer |
details
|
|
| GO Classification
|
| Biological Process |
| protein glycosylation |
| oligosaccharide biosynthetic process |
| cell-cell recognition |
| macromolecule glycosylation |
| Cellular Component |
| integral to membrane |
| membrane |
| Golgi cisterna membrane |
| Molecular Function |
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity |
| alpha-(1->3)-fucosyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 42116.69 |
| Theoretical pI
| 9.006 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|4503809|ref|NP_000140.1| galactoside 3(4)-L-fucosyltransferase [Homo sapiens]
MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTR
PTLLILLWTW
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P21217 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:4014 |
| References |
|---|
| General References
| Not Available |
