Human Metabolome Database: Showing Protein Ubiquitin conjugation factor E4 A (HMDBP11575)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 metabolites

Identification

HMDB Protein ID

HMDBP11575

Secondary Accession Numbers

21019

Name

Ubiquitin conjugation factor E4 A

Synonyms

Not Available

Gene Name

UBE4A

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein binding

Specific Function

Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
ubiquitin ligase complex
macromolecular complex
protein complex
Function
catalytic activity
ubiquitin-ubiquitin ligase activity
small conjugating protein ligase activity
ubiquitin-protein ligase activity
acid-amino acid ligase activity
protein binding
binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
Process
protein ubiquitination
macromolecule metabolic process
macromolecule modification
protein modification process
metabolic process
protein modification by small protein conjugation or removal
protein modification by small protein conjugation
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process

Cellular Location

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11q23.3

SNPs

UBE4A

Gene Sequence

>3201 bp
ATGACAGACCAGGAGAATAACAACAACATCTCAAGTAACCCCTTTGCTGCTCTTTTTGGC
TCCCTGGCTGATGCCAAACAGTTTGCGGCAATCCAAAAAGAGCAGCTGAAGCAACAATCT
GATGAACTCCCAGCTAGCCCAGATGACTCGGATAATAGCGTGTCAGAGAGCCTGGATGAA
TTCGATTACTCTGTGGCTGAGATTAGCCGCTCATTCCGATCACAGCAGGAAATATGTGAG
CAACTCAACATCAATCACATGATCCAAAGGATCTTCCTTATTACTCTGGACAACAGTGAT
CCCAGCTTGAAAAGCGGGAATGGCATCCCTAGCCGTTGTGTGTATTTGGAAGAAATGGCA
GTAGAGCTAGAAGATCAAGACTGGCTTGATATGAGCAATGTTGAGCAGGCCCTCTTCGCT
CGCTTATTACTTCAAGATCCAGGCAACCACTTAATTAACATGACTTCTTCTACAACGCTA
AATCTCTCTGCTGATCGAGATGCAGGAGAGAGGCACATTTTTTGTTACCTTTACTCCTGC
TTCCAGAGAGCCAAGGAAGAGATTACCAAAGTTCCAGAGAACCTGCTACCCTTTGCAGTG
CAGTGCAGAAACCTCACTGTGTCCAATACCCGAACAGTTCTTCTCACCCCAGAGATCTAT
GTTGACCAAAACATCCATGAGCAACTGGTAGATTTGATGTTAGAAGCCATCCAGGGAGCC
CATTTTGAAGATGTAACTGAGTTTCTGGAAGAGGTCATTGAAGCCTTGATATTGGATGAG
GAAGTTAGAACATTTCCAGAAGTCATGATTCCAGTGTTTGATATTTTATTGGGCCGAATA
AAAGATCTAGAGCTCTGTCAGATCCTTTTGTATGCATATCTGGATATTCTTCTCTATTTC
ACTAGGCAAAAAGATATGGCAAAGGTTTTTGTAGAATACATTCAGCCCAAGGACCCTACC
AATGGGCAAATGTACCAGAAGACCTTGCTGGGAGTAATTCTGAGTATCTCCTGCTTATTA
AAGACTCCGGGTGTTGTAGAAAATCATGGCTACTTTTTGAATCCATCTCGTTCCAGCCCC
CAGGAGATCAAAGTACAGGAGGCCAACATCCATCAGTTCATGGCTCAGTTCCACGAAAAG
ATCTACCAGATGCTGAAGAACTTACTCCAGCTCTCTCCAGAAACCAAACACTGTATCTTG
TCCTGGCTTGGAAACTGTTTGCATGCAAATGCAGGCCGCACCAAGATTTGGGCCAATCAG
ATGCCAGAAATCTTTTTCCAAATGTATGCCTCAGATGCTTTCTTTCTGAATCTGGGTGCT
GCTCTCCTGAAGCTATGCCAGCCATTTTGCAAACCCAGATCCTCTCGGCTCCTCACCTTT
AATCCCACATACTGTGCCCTCAAGGAGTTGAATGATGAAGAACGAAAAATTAAAAATGTA
CACATGAGAGGTTTGGACAAAGAAACCTGTTTGATCCCAGCTGTGCAGGAGCCGAAGTTT
CCACAGAACTACAACCTTGTAACAGAGAACCTTGCTCTGACAGAGTACACCTTGTACTTG
GGATTTCACAGGTTGCATGATCAGATGGTAAAAATCAACCAAAATCTGCATCGGCTGCAG
GTTGCCTGGCGGGATGCTCAGCAAAGTTCTAGCCCTGCTGCTGACAATCTTCGTGAGCAG
TTTGAACGACTGATGACCATCTATCTTTCTACCAAGACTGCCATGACAGAGCCACAAATG
CTACAAAACTGCCTAAACTTGCAGGTGTCCATGGCTGTTCTACTGGTTCAACTGGCCATA
GGCAATGAGGGCTCACAGCCAATAGAGCTAACCTTTCCTTTGCCAGATGGCTACAGCTCT
TTGGCTTATGTGCCAGAATTTTTTGCAGATAACCTGGGTGATTTTCTCATTTTTCTCCGC
CGCTTTGCCGATGACATTTTGGAGACATCAGCAGATTCCCTGGAGCATGTCCTTCACTTT
ATCACCATTTTCACTGGAAGCATAGAAAGAATGAAGAATCCCCACCTGAGGGCCAAACTA
GCAGAGGTGTTGGAAGCAGTGATGCCCCACCTGGATCAGACCCCAAATCCCTTGGTATCC
AGTGTGTTCCACCGGAAACGTGTGTTCTGCAACTTTCAGTATGCACCCCAACTTGCAGAG
GCTCTAATCAAGGTTTTTGTGGACATCGAATTTACAGGAGACCCCCATCAATTTGAACAG
AAGTTTAATTACCGCCGTCCCATGTATCCTATCCTAAGATACATGTGGGGGACAGATACC
TATCGGGAGAGCATTAAGGATTTGGCTGACTATGCCTCTAAGAATTTAGAAGCCATGAAT
CCCCCACTTTTCCTCCGCTTTCTTAACCTGCTAATGAATGATGCCATCTTCCTTTTGGAT
GAAGCCATACAGTATTTGAGCAAGATAAAGATTCAGCAAATTGAGAAGGATCGAGGTGAA
TGGGATAGTCTGACTCCAGAAGCCCGCCGAGAAAAGGAGGCTGGCCTACAGATGTTTGGA
CAGCTGGCACGTTTCCATAACATCATGTCCAATGAAACAATCGGTACCCTTGCCTTTCTC
ACATCAGAGATCAAGTCACTCTTTGTGCATCCCTTCCTGGCTGAGCGCATCATCTCCATG
TTGAACTACTTCCTGCAACACCTGGTTGGCCCCAAGATGGGTGCCTTAAAAGTCAAGGAC
TTCAGCGAATTTGACTTCAAACCCCAGCAGCTTGTATCAGATATCTGCACTATCTACTTA
AATCTTGGGGATGAGGAGAATTTCTGTGCCACTGTGCCCAAGGATGGACGTTCCTATTCC
CCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAATATG
ATTATGGCTTTCAGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAG
GAAGAGGAAACCTATGCAGATGCCTGTGATGAGTTCCTGGATCCCATTATGAGCACACTG
ATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCATTGCA
AGACATTTGCTCAGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAG
ATCCGGCCAAACACAGAACTAAAAGAAAAAATCCAACGGTGGCTTGCAGAGAGGAAACAA
CAAAAGGAGCAACTTGAATAG

Protein Properties

Number of Residues

1066

Molecular Weight

122559.3

Theoretical pI

4.87

Pfam Domain Function

U-box (PF04564 )
Ufd2P_core (PF10408 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Ubiquitin conjugation factor E4 A
MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDE
FDYSVAEISRSFRSQQEICEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMA
VELEDQDWLDMSNVEQALFARLLLQDPGNHLINMTSSTTLNLSADRDAGERHIFCYLYSC
FQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGA
HFEDVTEFLEEVIEALILDEEVRTFPEVMIPVFDILLGRIKDLELCQILLYAYLDILLYF
TRQKDMAKVFVEYIQPKDPTNGQMYQKTLLGVILSISCLLKTPGVVENHGYFLNPSRSSP
QEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILSWLGNCLHANAGRTKIWANQ
MPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCALKELNDEERKIKNV
HMRGLDKETCLIPAVQEPKFPQNYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQ
VAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAI
GNEGSQPIELTFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFADDILETSADSLEHVLHF
ITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPNPLVSSVFHRKRVFCNFQYAPQLAE
ALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDTYRESIKDLADYASKNLEAMN
PPLFLRFLNLLMNDAIFLLDEAIQYLSKIKIQQIEKDRGEWDSLTPEARREKEAGLQMFG
QLARFHNIMSNETIGTLAFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKD
FSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNM
IMAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIA
RHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQLE

External Links

GenBank ID Protein

111494032

UniProtKB/Swiss-Prot ID

Q14139

UniProtKB/Swiss-Prot Entry Name

UBE4A_HUMAN

PDB IDs

1WGM

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

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Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed:12665801 ]
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1995 Aug 31;2(4):167-74, 199-210. [PubMed:8590280 ]