| Identification |
|---|
| HMDB Protein ID
| HMDBP10846 |
| Secondary Accession Numbers
| |
| Name
| Potassium voltage-gated channel subfamily A member 4 |
| Synonyms
|
- HPCN2
- Voltage-gated K(+) channel HuKII
- Voltage-gated potassium channel HBK4
- Voltage-gated potassium channel HK1
- Voltage-gated potassium channel subunit Kv1.4
|
| Gene Name
| KCNA4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| voltage-gated potassium channel complex |
| integral to membrane |
| intrinsic to membrane |
| membrane part |
| membrane |
| protein complex |
| macromolecular complex |
| ion channel complex |
| cell part |
| cation channel complex |
| potassium channel complex |
| Function |
| voltage-gated potassium channel activity |
| potassium channel activity |
| cation channel activity |
| cation binding |
| ion channel activity |
| ion transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| transmembrane transporter activity |
| potassium ion binding |
| alkali metal ion binding |
| transporter activity |
| protein binding |
| binding |
| metal ion binding |
| ion binding |
| Process |
| cation transport |
| transmembrane transport |
| ion transport |
| transport |
| establishment of localization |
| monovalent inorganic cation transport |
| potassium ion transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p14 |
| SNPs
| KCNA4 |
| Gene Sequence
|
>1962 bp
ATGGAGGTTGCAATGGTGAGTGCGGAGAGCTCAGGGTGCAACAGTCACATGCCTTATGGT
TATGCTGCCCAGGCCCGGGCCCGGGAGCGGGAGAGGCTTGCTCACTCCAGGCGAGCTGCA
GCACGTGCTGTTGCAGCGGCCACAGCTGCTGTCGAAGGTAGCGGGGGTTCTGGTGGGGGC
TCCCACCACCACCACCAGTCACGCGGGGCCTGTACCTCCCATGACCCTCAGAGCAGCCGG
GGTAGTCGGGAGGAGGAGGCGACACGGTCTGAGAAGAAGAAAGCCCACTACCGGCAGAGC
AGCTTCCCTCATTGCTCTGACCTGATGCCCAGTGGCTCTGAGGAGAAGATCCTGAGGGAG
CTGAGTGAGGAGGAGGAAGATGAGGAGGAGGAGGAAGAGGAGGAAGAGGAGGGAAGGTTT
TACTATAGTGAAGATGACCATGGTGATGAGTGTTCCTACACGGATCTGCTGCCTCAGGAT
GAGGGCGGTGGCGGCTACAGTTCAGTCCGCTACAGTGACTGTTGTGAACGTGTGGTGATA
AATGTGTCAGGCCTACGCTTTGAGACCCAAATGAAAACTCTGGCCCAGTTTCCAGAGACT
TTGTTGGGAGACCCTGAAAAGAGGACTCAGTACTTTGACCCTTTGCGCAATGAGTATTTT
TTTGACAGGAACCGCCCCAGCTTTGATGCCATCTTGTATTATTATCAATCAGGAGGCCGC
CTGAAGAGGCCAGTCAATGTCCCCTTTGATATCTTCACTGAGGAGGTGAAGTTCTATCAG
TTGGGGGAGGAGGCCCTGTTGAAGTTTCGGGAGGACGAGGGCTTTGTGAGAGAAGAGGAA
GACAGGGCCCTCCCCGAGAATGAATTTAAAAAGCAGATTTGGCTCCTCTTTGAATATCCA
GAGAGCTCCGATCCTGCAAGGGGCATAGCCATTGTGTCCGTCCTGGTCATCTTAATCTCC
ATTGTCATCTTTTGCCTGGAAACCTTGCCTGAGTTTAGGGACGACAGGGATCTCGTCATG
GCACTGAGTGCTGGCGGGCATGGTGGGTTGTTGAATGATACTTCAGCACCCCATCTGGAG
AACTCAGGGCACACAATATTCAATGACCCCTTCTTCATCGTGGAAACAGTCTGTATTGTA
TGGTTTTCCTTTGAGTTTGTGGTTCGCTGCTTTGCTTGTCCCAGCCAAGCACTCTTCTTC
AAAAACATCATGAACATCATTGACATTGTCTCCATTTTGCCTTACTTCATCACACTGGGC
ACTGACCTGGCCCAGCAACAGGGGGGTGGCAATGGTCAGCAGCAGCAGGCCATGTCCTTT
GCCATCCTCAGAATCATTCGTCTGGTCCGAGTATTCCGGATCTTCAAACTCTCCAGGCAC
TCCAAAGGCCTGCAGATCCTGGGCCACACCCTCAGAGCCAGCATGCGGGAACTGGGCCTT
CTGATCTTCTTCCTCTTCATTGGGGTCATCCTCTTTTCTAGTGCTGTGTATTTTGCAGAG
GCGGATGAACCTACTACCCATTTCCAAAGCATCCCAGATGCATTTTGGTGGGCTGTGGTG
ACCATGACAACTGTGGGCTATGGGGACATGAAGCCCATCACTGTAGGGGGCAAGATTGTC
GGGGTCCTGTGTGCCATTGCGGGTGTCTTAACCATTGCTTTGCCAGTGCCAGTGATTGTC
TCTAACTTTAACTATTTCTACCACAGAGAGACTGAAAATGAGGAACAGACACAGCTAACG
CAGAATGCAGTCAGTTGTCCATACCTCCCCTCTAATTTGCTCAAGAAATTTCGGAGCTCT
ACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTAGAGATGGAAGAAGGAGTTAAGGAA
TCTCTGTGTGCCAAGGAGGAGAAGTGTCAGGCCAAGGGGGATGACAGTGAGACAGATAAA
AACAACTGTTCTAATGCAAAGGCTGTGGAGACTGATGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 653 |
| Molecular Weight
| 73287.6 |
| Theoretical pI
| 4.67 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 308-326
- 371-392
- 404-424
- 443-461
- 478-497
- 539-561
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily A member 4
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRRAAARAVAAATAAVEGSGGSGGG
SHHHHQSRGACTSHDPQSSRGSREEEATRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE
LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI
NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR
LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP
ESSDPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE
NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG
TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL
LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV
GVLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS
TSSSLGDKSEYLEMEEGVKESLCAKEEKCQAKGDDSETDKNNCSNAKAVETDV
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P22459 |
| UniProtKB/Swiss-Prot Entry Name
| KCNA4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M55514 |
| GeneCard ID
| KCNA4 |
| GenAtlas ID
| KCNA4 |
| HGNC ID
| HGNC:6222 |
| References |
|---|
| General References
| - Philipson LH, Hice RE, Schaefer K, LaMendola J, Bell GI, Nelson DJ, Steiner DF: Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):53-7. [PubMed:1986382 ]
- Philipson LH, Schaefer K, LaMendola J, Bell GI, Steiner DF: Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4. Nucleic Acids Res. 1990 Dec 11;18(23):7160. [PubMed:2263489 ]
- Tamkun MM, Knoth KM, Walbridge JA, Kroemer H, Roden DM, Glover DM: Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. FASEB J. 1991 Mar 1;5(3):331-7. [PubMed:2001794 ]
- Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR: NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. Nature. 1997 Jan 16;385(6613):272-5. [PubMed:9000078 ]
|
