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Showing Protein Receptor-type tyrosine-protein phosphatase H (HMDBP10092)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP10092
Secondary Accession Numbers
  • 16040
Name Receptor-type tyrosine-protein phosphatase H
Synonyms
  1. R-PTP-H
  2. SAP-1
  3. Stomach cancer-associated protein tyrosine phosphatase 1
  4. Transmembrane-type protein-tyrosine phosphatase type H
Gene Name PTPRH
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.
Pathways Not Available
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
GO Classification
Biological Process
apoptotic process
Cellular Component
integral to plasma membrane
nucleus
mitochondrion
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphoric ester hydrolase activity
phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
Molecular Function
transmembrane receptor protein tyrosine phosphatase activity
Process
protein amino acid dephosphorylation
dephosphorylation
phosphate metabolic process
phosphorus metabolic process
cellular metabolic process
metabolic process
Cellular Location
  1. Cytoplasm
  2. Membrane
  3. Single-pass type I membrane protein (Potential)
Gene Properties
Chromosome Location 19
Locus 19q13.4
SNPs PTPRH
Gene Sequence 
>3348 bp
ATGGCTGGGGCTGGCGGGGGCCTCGGGGTCTGGGGGAACCTGGTGCTGCTGGGCCTGTGC
AGCTGGACAGGGGCCAGGGCGCCTGCCCCCAACCCAGGGAGGAACCTGACAGTGGAGACT
CAGACCACCAGCTCCATCTCCCTGAGCTGGGAGGTCCCCGATGGCCTAGACTCACAGAAC
TCCAACTACTGGGTTCAGTGTACTGGAGACGGCGGCACAACAGAGACTCGAAACACAACA
GCCACCAACGTCACCGTGGATGGCCTTGGACCCGGGTCATTGTATACGTGTTCTGTGTGG
GTGGAGAAAGACGGAGTAAATAGCTCTGTGGGGACTGTCACTACTGCCACAGCTCCCAAC
CCAGTGAGGAACCTGAGAGTGGAGGCTCAGACCAACAGCTCCATCGCCCTGACCTGGGAG
GTCCCCGACGGCCCAGACCCACAGAACTCCACCTACGGGGTTGAGTACACTGGAGATGGT
GGCAGAGCAGGGACTCGAAGCACAGCACACACTAACATCACCGTGGATGGACTTGAACCC
GGGTGTTTGTATGCGTTTTCCATGTGGGTGGGAAAGAATGGAATCAACAGCTCCCGGGAG
ACTCGAAATGCCACCACAGCTCACAACCCAGTGAGGAACCTGAGAGTGGAGGCTCAGACC
ACCAGCTCCATCTCCCTGAGCTGGGAGGTCCCCGATGGCACAGACCCACAGAACTCGACC
TACTGCGTTCAGTGCACTGGAGATGGTGGCAGAACAGAGACTCGAAACACAACAGACACC
AGAGTCACCGTGGATGGCCTTGGACCCGGGTCATTGTATACGTGTTCTGTGTGGGTGGAG
AAAGACGGAGTAAATAGCTCTGTGGAGATTGTCACTAGTGCCACAGCTCCCAACCCAGTG
AGAAACCTGACAGTGGAGGCTCAGACCAACAGCTCCATCGCCCTGACCTGGGAGGTCCCC
GATGGCCCAGACCCACAGAACTCCACCTACGGGGTTGAGTACACTGGAGATGGTGGCAGA
GCAGGGACTCGAAGCACAGCACACACCAACATCACCGTGGATAGACTTGAACCCGGGTGT
TTGTATGTGTTTTCCGTGTGGGTGGGGAAGAATGGAATCAACAGCTCCCGGGAGACTCGA
AATGCCACCACAGCCCCCAACCCAGTGAGAAACCTCCATATGGAGACTCAGACCAACAGC
TCCATCGCCCTATGCTGGGAAGTCCCCGATGGCCCATACCCTCAGGACTACACCTACTGG
GTAGAGTACACTGGAGACGGTGGTGGCACAGAGACCCGAAACACAACAAATACCAGTGTG
ACAGCTGAGAGACTTGAGCCCGGAACCTTGTACACATTCTCTGTATGGGCAGAAAAAAAT
GGAGCACGTGGCTCCAGGCAGAATGTCAGCATCTCCACAGTCCCCAACGCAGTGACAAGC
CTCAGCAAGCAGGACTGGACCAACAGCACCATTGCTTTGCGCTGGACAGCTCCCCAGGGC
CCAGGCCAGTCTTCCTACAGCTACTGGGTCTCATGGGTCAGGGAAGGCATGACTGACCCC
AGGACCCAAAGCACCTCAGGTACTGACATCACCCTAAAGGAACTGGAAGCTGGCAGCCTG
TACCACCTCACCGTCTGGGCCGAGAGGAATGAGGTCAGAGGCTATAACAGCACCCTCACT
GCAGCCACTGCTCCCAATGAGGTCACAGATCTCCAGAATGAAACTCAGACTAAGAACTCA
GTCATGCTGTGGTGGAAGGCCCCTGGAGACCCCCACTCTCAGTTGTACGTATACTGGGTC
CAGTGGGCCAGCAAGGGACATCCCCGGAGGGGGCAAGATCCCCAAGCGAATTGGGTCAAC
CAGACCAGCAGGACCAATGAGACGTGGTACAAAGTGGAGGCCCTGGAACCCGGGACGTTG
TACAATTTCACCGTGTGGGCAGAGAGGAATGACGTAGCCAGTTCCACGCAGAGCCTCTGT
GCGTCCACATACCCAGACACAGTCACCATCACTTCCTGTGTCAGCACCTCAGCGGGCTAT
GGAGTCAACTTGATCTGGTCCTGCCCCCAGGGAGGCTACGAGGCCTTTGAGTTGGAGGTG
GGAGGACAGCGGGGCTCCCAGGACAGATCTTCATGTGGGGAGGCTGTGTCTGTGTTGGGT
CTCGGGCCGGCTCGGTCCTACCCAGCCACCATCACGACCATCTGGGACGGAATGAAGGTC
GTGTCTCACTCTGTGGTCTGCCACACCGAGAGTGCAGGGGTCATTGCCGGAGCCTTTGTG
GGCATCCTCCTGTTTCTCATCCTCGTGGGCCTGCTGATTTTCTTCCTGAAGAGGAGGAAT
AAGAAGAAGCAGCAGAAACCAGAACTCAGGGATCTGGTCTTTAGCTCCCCAGGGGACATC
CCAGCTGAAGACTTCGCTGACCACGTCAGGAAGAATGAGAGGGACAGCAACTGTGGTTTT
GCAGACAAGTACCAGCAACTCTCCCTGGTGGGCCACAGCCAGTCTCAGATGGTGGCTTCG
GCTTCAGAGAACAACGCCAAGAACCGCTACAGAAATGTGCTGCCCTATGACTGGTCCCGG
GTGCCCCTGAAGCCCATCCATGAGGAGCCAGGCTCTGACTACATCAATGCCAGCTTCATG
CCCGGTCTCTGGAGCCCCCAGGAGTTCATTGCAACCCAGGGTCCCCTGCCACAGACAGTG
GGTGACTTCTGGCGCCTGGTGTGGGAACAGCAGAGCCACACCCTGGTCATGCTGACCAAC
TGCATGGAGGCCGGCCGGGTGAAGTGTGAGCATTACTGGCCTCTGGACTCGCAGCCCTGC
ACCCATGGGCACCTGCGGGTAACCCTGGTAGGTGAGGAAGTGATGGAGAACTGGACGGTG
CGGGAACTGCTGCTCCTCCAGGTGGAGGAGCAGAAGACACTGTCTGTGCGCCAATTCCAC
TACCAGGCCTGGCCGGATCACGGCGTTCCCTCCTCCCCAGACACCTTGCTGGCTTTCTGG
AGGATGCTTCGGCAGTGGCTGGATCAGACCATGGAGGGAGGCCCACCCATTGTGCACTGC
AGTGCTGGCGTGGGTCGCACAGGAACCCTCATTGCCCTGGACGTCCTGCTCCGGCAGCTG
CAGTCCGAGGGTCTCCTTGGGCCCTTCAGCTTTGTAAGGAAGATGAGAGAGAGTCGGCCG
TTGATGGTGCAGACTGAGGCTCAGTACGTATTCCTGCATCAGTGCATCCTGCGGTTCCTC
CAACAGTCAGCCCAGGCCCCAGCCGAGAAGGAAGTCCCGTATGAGGATGTCGAAAACCTC
ATCTACGAGAACGTGGCCGCCATCCAGGCCCACAAGTTGGAGGTCTAA
Protein Properties
Number of Residues 1115
Molecular Weight 103411.89
Theoretical pI 5.513
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Receptor-type tyrosine-protein phosphatase H
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN
SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN
PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP
GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST
YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV
RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGC
LYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYW
VEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS
LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL
YHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV
QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLC
ASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLG
LGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRN
KKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVAS
ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV
GDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTV
RELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHC
SAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
QQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
GenBank ID Protein 241896924
UniProtKB/Swiss-Prot ID Q9HD43
UniProtKB/Swiss-Prot Entry Name PTPRH_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_002842.3
GeneCard ID PTPRH
GenAtlas ID PTPRH
HGNC ID HGNC:9672
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed:15057824 ]
  3. Ito T, Okazawa H, Maruyama K, Tomizawa K, Motegi S, Ohnishi H, Kuwano H, Kosugi A, Matozaki T: Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function. J Biol Chem. 2003 Sep 12;278(37):34854-63. Epub 2003 Jul 1. [PubMed:12837766 ]
  4. Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al.: Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers. J Biol Chem. 1994 Jan 21;269(3):2075-81. [PubMed:8294459 ]
  5. Marneros AG, Mehenni H, Reichenberger E, Antonarakis SE, Krieg T, Olsen BR: Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome. Cytogenet Cell Genet. 2001;92(3-4):213-6. [PubMed:11435690 ]
  6. Noguchi T, Tsuda M, Takeda H, Takada T, Inagaki K, Yamao T, Fukunaga K, Matozaki T, Kasuga M: Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas. J Biol Chem. 2001 May 4;276(18):15216-24. Epub 2001 Feb 14. [PubMed:11278335 ]
  7. Takada T, Noguchi T, Inagaki K, Hosooka T, Fukunaga K, Yamao T, Ogawa W, Matozaki T, Kasuga M: Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1. J Biol Chem. 2002 Sep 13;277(37):34359-66. Epub 2002 Jul 5. [PubMed:12101188 ]
  8. Nagano H, Noguchi T, Inagaki K, Yoon S, Matozaki T, Itoh H, Kasuga M, Hayashi Y: Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma. Oncogene. 2003 Jul 24;22(30):4656-63. [PubMed:12879010 ]
  9. Walchli S, Espanel X, Hooft van Huijsduijnen R: Sap-1/PTPRH activity is regulated by reversible dimerization. Biochem Biophys Res Commun. 2005 Jun 3;331(2):497-502. [PubMed:15850787 ]