Human Metabolome Database: Showing Protein G protein-coupled receptor kinase 7 (HMDBP09511)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 metabolites

Identification

HMDB Protein ID

HMDBP09511

Secondary Accession Numbers

15410

Name

G protein-coupled receptor kinase 7

Synonyms

G protein-coupled receptor kinase GRK7

Gene Name

GRK7

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein serine/threonine kinase activity

Specific Function

Phosphorylates cone opsins thereby initiating their deactivation

Pathways

Not Available

Reactions

Not Available

GO Classification

Function
catalytic activity
g-protein coupled receptor kinase activity
protein serine/threonine kinase activity
protein kinase activity
signal transducer activity
molecular transducer activity
atp binding
adenyl ribonucleotide binding
purine nucleoside binding
binding
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
adenyl nucleotide binding
Process
cellular metabolic process
regulation of biological process
biological regulation
regulation of cellular process
signal transduction
phosphorus metabolic process
phosphate metabolic process
phosphorylation
protein amino acid phosphorylation
metabolic process

Cellular Location

Lipid-anchor
Membrane

Gene Properties

Chromosome Location

Chromosome:3

Locus

3q24

SNPs

GRK7

Gene Sequence

>1662 bp
ATGGTGGACATGGGGGCCCTGGACAACCTGATCGCCAACACCGCCTACCTGCAGGCCCGG
AAGCCCTCGGACTGCGACAGCAAAGAGCTGCAGCGGCGGCGGCGTAGCCTGGCCCTGCCC
GGGCTGCAGGGCTGCGCGGAGCTCCGCCAGAAGCTGTCCCTGAACTTCCACAGCCTGTGT
GAGCAGCAGCCCATCGGTCGCCGCCTCTTCCGTGACTTCCTAGCCACAGTGCCCACGTTC
CGCAAGGCGGCAACCTTCCTAGAGGACGTGCAGAACTGGGAGCTGGCCGAGGAGGGACCC
ACCAAAGACAGCGCGCTGCAGGGGCTGGTGGCCACTTGTGCGAGTGCCCCTGCCCCGGGG
AACCCGCAACCCTTCCTCAGCCAGGCCGTGGCCACCAAGTGCCAAGCAGCCACCACTGAG
GAAGAGCGAGTGGCTGCAGTGACGCTGGCCAAGGCTGAGGCCATGGCTTTCTTGCAAGAG
CAGCCCTTTAAGGATTTCGTGACCAGCGCCTTCTACGACAAGTTTCTGCAGTGGAAACTC
TTCGAGATGCAACCAGTGTCAGACAAGTACTTCACTGAGTTCAGAGTGCTGGGGAAAGGT
GGTTTTGGGGAGGTATGTGCCGTCCAGGTGAAAAACACTGGGAAGATGTATGCCTGTAAG
AAACTGGACAAGAAGCGGCTGAAGAAGAAAGGTGGCGAGAAGATGGCTCTCTTGGAAAAG
GAAATCTTGGAGAAGGTCAGCAGCCCTTTCATTGTCTCTCTGGCCTATGCCTTTGAGAGC
AAGACCCATCTCTGCCTTGTCATGAGCCTGATGAATGGGGGAGACCTCAAGTTCCACATC
TACAACGTGGGCACGCGTGGCCTGGACATGAGCCGGGTGATCTTTTACTCGGCCCAGATA
GCCTGTGGGATGCTGCACCTCCATGAACTCGGCATCGTCTATCGGGACATGAAGCCTGAG
AATGTGCTTCTGGATGACCTCGGCAACTGCAGGTTATCTGACCTGGGGCTGGCCGTGGAG
ATGAAGGGTGGCAAGCCCATCACCCAGAGGGCTGGAACCAATGGTTACATGGCTCCTGAG
ATCCTAATGGAAAAGGTAAGTTATTCCTATCCTGTGGACTGGTTTGCCATGGGATGCAGC
ATTTATGAAATGGTTGCTGGACGAACACCATTCAAAGATTACAAGGAAAAGGTCAGTAAA
GAGGATCTGAAGCAAAGAACTCTGCAAGACGAGGTCAAATTCCAGCATGATAACTTCACA
GAGGAAGCAAAAGATATTTGCAGGCTCTTCTTGGCTAAGAAACCAGAGCAACGCTTAGGA
AGCAGAGAAAAGTCTGATGATCCCAGGAAACATCATTTCTTTAAAACGATCAACTTTCCT
CGCCTGGAAGCTGGCCTAATTGAACCCCCATTTGTGCCAGACCCTTCAGTGGTTTATGCC
AAAGACATCGCTGAAATTGATGATTTCTCTGAGGTTCGGGGGGTGGAATTTGATGACAAA
GATAAGCAGTTCTTCAAAAACTTTGCGACAGGTGCTGTTCCTATAGCATGGCAGGAAGAA
ATTATAGAAACGGGACTGTTTGAGGAACTGAATGACCCCAACAGACCTACGGGTTGTGAG
GAGGGTAATTCATCCAAGTCTGGCGTGTGTTTGTTATTGTAA

Protein Properties

Number of Residues

553

Molecular Weight

62211.0

Theoretical pI

6.52

Pfam Domain Function

Pkinase (PF00069 )
RGS (PF00615 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>G protein-coupled receptor kinase 7
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC
EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG
NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL
FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK
EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI
ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE
ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT
EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA
KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE
EGNSSKSGVCLLL

External Links

GenBank ID Protein

17026318

UniProtKB/Swiss-Prot ID

Q8WTQ7

UniProtKB/Swiss-Prot Entry Name

GRK7_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W: Characterization of human GRK7 as a potential cone opsin kinase. Mol Vis. 2001 Dec 21;7:305-13. [PubMed:11754336 ]
Weiss ER, Ducceschi MH, Horner TJ, Li A, Craft CM, Osawa S: Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction. J Neurosci. 2001 Dec 1;21(23):9175-84. [PubMed:11717351 ]