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Showing Protein Serine/threonine-protein kinase SBK1 (HMDBP09474)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP09474
Secondary Accession Numbers
  • 15363
Name Serine/threonine-protein kinase SBK1
Synonyms
  1. SH3-binding kinase 1
Gene Name SBK1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function May be involved in signal-transduction pathways related to the control of brain development
Pathways Not Available
Reactions Not Available
GO Classification
Function
adenyl ribonucleotide binding
protein serine/threonine kinase activity
protein kinase activity
protein binding
atp binding
binding
adenyl nucleotide binding
purine nucleoside binding
nucleoside binding
kinase activity
transferase activity, transferring phosphorus-containing groups
transferase activity
catalytic activity
Process
cellular metabolic process
phosphorus metabolic process
phosphate metabolic process
phosphorylation
metabolic process
protein amino acid phosphorylation
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 16p11.2
SNPs SBK1
Gene Sequence 
>1275 bp
ATGAGCGTGGGCTGCCCAGAGCCTGAGCCGCCCCGCTCCCTGACCTGCTGTGGGCCGGGG
ACTGCCCCTGGGCCTGGTGCCGGTGTGCCCCTTCTCACTGAAGACATGCAGGCCCTGACT
CTCCGCACACTGGCCGCCAGCGACGTCACCAAGCACTACGAACTAGTCCGGGAGCTGGGC
AAAGGCACCTATGGGAAGGTTGACCTGGTGGTCTACAAGGGCACAGGCACAAAAATGGCA
CTGAAGTTTGTGAACAAGAGCAAAACCAAGCTGAAGAACTTCCTACGGGAGGTGAGCATC
ACCAACAGCCTCTCCTCCAGCCCCTTCATCATCAAGGTCTTTGACGTGGTCTTTGAGACA
GAGGACTGCTACGTCTTTGCCCAGGAGTACGCACCTGCTGGGGACCTGTTTGACATCATC
CCTCCCCAGGTGGGGCTCCCTGAGGACACGGTGAAGCGCTGTGTGCAGCAGCTGGGCCTG
GCGCTGGACTTCATGCACGGGCGGCAGCTGGTGCACCGCGACATCAAGCCCGAGAACGTG
CTGCTGTTCGACCGCGAGTGCCGCCGCGTAAAGCTGGCCGACTTCGGCATGACGCGCCGC
GTGGGCTGCCGCGTCAAGCGCGTGAGCGGCACCATCCCTTACACGGCGCCTGAGGTGTGC
CAGGCGGGCCGCGCCGACGGGCTGGCGGTGGACACGGGCGTGGACGTGTGGGCCTTCGGC
GTGCTCATCTTCTGCGTGCTCACCGGCAACTTCCCGTGGGAGGCGGCGTCGGGCGCCGAC
GCCTTCTTCGAGGAGTTCGTGCGCTGGCAGCGGGGCCGCCTGCCGGGGCTGCCTTCGCAG
TGGCGCCGCTTCACCGAGCCCGCGCTGCGCATGTTCCAGCGCTTACTGGCCCTGGAGCCC
GAGCGCCGCGGCCCAGCCAAGGAGGTGTTCCGCTTCCTCAAGCACGAGCTCACGTCCGAG
CTGCGCCGCCGGCCCTCGCACCGCGCGCGCAAGCCCCCCGGGGACCGCCCGCCCGCCGCC
GGGCCACTGCGCCTCGAGGCGCCTGGGCCGCTCAAGCGGACGGTGCTGACCGAGAGCGGC
AGCGGCTCCCGGCCCGCGCCCCCCGCCGTCGGGTCGGTGCCCTTGCCCGTGCCGGTGCCG
GTGCCAGTGCCCGTGCCGGTGCCTGTGCCCGAGCCCGGCCTAGCTCCCCAGGGGCCCCCC
GGCCGGACCGACGGCCGCGCGGACAAGAGCAAAGGGCAGGTGGTGCTGGCCACGGCCATC
GAGATCTGCGTCTGA
Protein Properties
Number of Residues 424
Molecular Weight 46251.3
Theoretical pI 9.47
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Serine/threonine-protein kinase SBK1
MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELG
KGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFET
EDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENV
LLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFG
VLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEP
ERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG
SGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAI
EICV
GenBank ID Protein 62005104
UniProtKB/Swiss-Prot ID Q52WX2
UniProtKB/Swiss-Prot Entry Name SBK1_HUMAN
PDB IDs Not Available
GenBank Gene ID AY874862
GeneCard ID SBK1
GenAtlas ID SBK1
HGNC ID HGNC:17699
References
General References
  1. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  2. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]