Human Metabolome Database: Showing Protein Phosphoinositide-3-kinase, class 2, beta polypeptide (HMDBP09440)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP09440

Secondary Accession Numbers

15321

Name

Phosphoinositide-3-kinase, class 2, beta polypeptide

Synonyms

SubName: Phosphoinositide-3-kinase, class 2, beta polypeptide, isoform CRA_b

Gene Name

PIK3C2B

Protein Type

Enzyme

Biological Properties

General Function

Involved in binding

Specific Function

Not Available

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
phosphoinositide 3-kinase complex
protein complex
macromolecular complex
Function
catalytic activity
1-phosphatidylinositol-3-kinase activity
phosphoinositide 3-kinase activity
lipid kinase activity
inositol or phosphatidylinositol kinase activity
phosphoinositide binding
phospholipid binding
lipid binding
kinase activity
binding
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
protein binding
Process
cellular process
phospholipid metabolic process
organophosphate metabolic process
cell communication
regulation of biological process
intracellular signal transduction
signal transduction
regulation of cellular process
metabolic process
second-messenger-mediated signaling
phosphoinositide-mediated signaling
glycerophospholipid metabolic process
phosphoinositide metabolic process
phosphoinositide phosphorylation
biological regulation

Cellular Location

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q32

SNPs

PIK3C2B

Gene Sequence

>4905 bp
ATGTCTTCGACTCAGGGCAATGGGGAACACTGGAAGTCCCTGGAGTCAGTGGGCATCAGC
CGCAAAGAGCTAGCGATGGCCGAAGCCCTGCAGATGGAGTATGATGCCCTGTCCCGGCTC
CGGCATGACAAGGAGGAGAACAGAGCCAAGCAGAACGCAGACCCCTCTCTCATCAGCTGG
GATGAGCCTGGGGTAGACTTTTACAGCAAGCCAGCAGGAAGGCGGACCGACCTCAAGCTG
TTACGCGGTCTCTCTGGCTCTGATCCTACCCTTAACTACAACTCACTATCCCCACAGGAA
GGGCCGCCCAACCACTCTACCTCCCAAGGGCCACAGCCTGGCTCAGATCCCTGGCCCAAA
GGCTCCCTGTCTGGAGACTATCTCTACATTTTTGATGGTTCAGATGGGGGAGTCTCTTCG
TCCCCAGGACCAGGGGACATAGAGGGCTCTTGCAAGAAACTATCCCCACCTCCTCTGCCT
CCCCGAGCTTCTATCTGGGATACCCCTCCCCTGCCTCCCAGAAAGGGGTCCCCCTCATCC
TCCAAGATCTCCCAGCCCAGTGACATCAACACTTTCTCTTTGGTCGAACAATTGCCAGGC
AAACTGCTAGAGCATCGGATCCTAGAAGAGGAAGAGGTGCTGGGAGGTGGGGGTCAGGGG
CGCCTACTGGGGTCTGTGGACTATGATGGTATCAATGATGCAATTACTAGGCTCAACTTG
AAATCGACCTATGATGCGGAGATGTTGCGGGATGCCACCAGGGGCTGGAAGGAGGGCCGA
GGGCCGCTGGACTTCAGCAAAGACACCTCTGGAAAACCCGTGGCCAGGAGCAAGACTATG
CCCCCTCAGGTGCCCCCCCGCACCTATGCCTCCCGCTATGGCAACCGAAAGAATGCGACG
CCTGGCAAGAACCGCCGGATTTCTGCAGCCCCGGTGGGCTCCCGGCCCCACACTGTTGCC
AATGGCCATGAGTTGTTTGAGGTCTCAGAAGAGAGAGATGAGGAGGTTGCTGCATTTTGC
CACATGCTGGATATCCTTCGATCTGGCTCTGACATCCAAGACTACTTCCTCACTGGCTAT
GTCTGGAGTGCTGTCACCCCTAGCCCAGAGCACCTCGGGGATGAGGTCAACCTGAAGGTG
ACTGTGTTGTGTGACAGGCTTCAAGAGGCACTCACTTTCACCTGCAACTGTTCCTCCACT
GTAGACTTGCTTATCTACCAGACCCTGTGCTACACCCATGATGACCTGAGGAATGTGGAC
GTGGGTGACTTTGTGCTAAAGCCCTGCGGGCTGGAGGAGTTCCTGCAGAACAAGCATGCC
TTGGGCAGTCATGAGTACATCCAATACTGCCGCAAGTTTGACATTGACATTCGGCTACAG
CTGATGGAGCAGAAGGTTGTGCGCAGTGACCTGGCCCGGACGGTGAATGATGACCAGAGC
CCCTCCACCTTGAACTACCTCGTCCATCTCCAAGAGAGGCCTGTCAAGCAGACCATCAGC
AGGCAGGCCCTGAGTCTTCTGTTCGACACTTACCACAATGAGGTGGATGCCTTCCTGCTG
GCTGATGGAGACTTCCCACTGAAGGCTGACAGGGTGGTCCAGTCCGTCAAGGCCATCTGC
AACGCCCTGGCCGCCGTGGAAACCCCTGAGATCACCAGTGCTCTCAACCAGCTGCCCCCC
TGCCCCTCCCGCATGCAGCCTAAAATTCAGAAGGATCCCAGTGTCTTGGCTGTGAGGGAA
AACCGAGAGAAGGTCGTGGAAGCCCTGACCGCTGCCATCTTGGACCTGGTGGAGCTGTAC
TGCAACACATTCAACGCAGACTTCCAGACGGCAGTGCCCGGGAGCCGCAAGCATGACCTG
GTCCAGGAGGCCTGCCATTTCGCCAGGTCCCTGGCCTTCACTGTCTATGCCACCCACCGC
ATCCCCATCATCTGGGCTACCAGCTATGAAGATTTCTACCTCTCCTGCTCCCTCAGCCAT
GGCGGCAAGGAGCTGTGCAGCCCCCTGCAGACCCGAAGAGCTCACTTCTCCAAGTACCTC
TTCCACCTCATCGTCTGGGACCAGCAGATCTGCTTCCCAGTGCAGGTGAACCGGCTGCCT
CGGGAGACACTGCTGTGTGCCACTCTCTATGCTCTGCCCATCCCCCCACCGGGGAGCTCC
TCAGAGGCCAATAAGCAGCGGCGGGTGCCTGAAGCCCTGGGCTGGGTCACTACCCCACTC
TTCAACTTCAGGCAGGTCCTGACCTGTGGCCGGAAGCTTCTGGGTTTGTGGCCAGCAACA
CAGGAAAATCCCAGCGCCCGTTGGAGTGCACCTAATTTCCACCAGCCAGACAGTGTCATC
CTGCAGATTGACTTCCCCACCTCGGCCTTTGACATCAAGTTCACCAGCCCCCCTGGAGAC
AAGTTCAGCCCCCGCTATGAGTTTGGCAGCCTCCGGGAAGAAGACCAGCGCAAGCTTAAA
GACATCATGCAGAAAGAGTCCTTGTACTGGCTCACTGATGCTGACAAGAAGCGCCTGTGG
GAGAAGCGATATTACTGCCACTCGGAGGTGAGCTCGCTCCCCCTGGTGCTCGCCAGCGCC
CCCAGCTGGGAGTGGGCTTGCCTGCCTGACATCTATGTTCTCCTGAAGCAGTGGACCCAC
ATGAACCACCAGGATGCCCTGGGGCTCCTGCATGCCACCTTCCCGGACCAGGAGGTGCGT
CGTATGGCTGTGCAGTGGATTGGCTCACTCTCAGATGCTGAGCTGCTAGACTACCTGCCC
CAGCTGGTACAGGCCCTGAAGTATGAATGCTACCTGGACAGCCCGTTGGTGCGCTTCCTC
CTGAAACGAGCTGTGTCTGACTTGAGAGTGACTCACTACTTCTTCTGGTTACTGAAGGAC
GGCCTCAAGGACTCTCAGTTCAGCATCCGCTACCAGTATCTGCTGGCAGCCTTACTGTGC
TGCTGTGGCAAGGGGCTGAGAGAAGAGTTTAACCGCCAGTGCTGGCTTGTCAATGCCCTG
GCCAAACTGGCCCAGCAGGTCCGGGAGGCAGCCCCATCTGCAAGGCAGGGAATCCTCCGC
ACGGGCCTGGAGGAGGTGAAGCAGTTCTTTGCCCTCAATGGCTCGTGCCGCTTGCCACTC
AGCCCCAGTCTGCTGGTTAAGGGAATTGTGCCCAGGGACTGTTCCTACTTCAACTCCAAT
GCTGTCCCCCTCAAACTCTCCTTCCAAAATGTGGATCCCCTGGGTGAGAACATCCGTGTC
ATCTTCAAGTGTGGGGACGACCTTCGCCAGGACATGCTAACGCTGCAGATGATTCGCATC
ATGAGCAAGATCTGGGTCCAGGAGGGGCTGGACATGCGCATGGTCATCTTCCGCTGCTTC
TCCACCGGCCGGGGCAGAGGGATGGTGGAGATGATCCCTAATGCTGAGACCCTGCGTAAG
ATCCAGGTGGAGCATGGGGTGACCGGCTCGTTCAAGGACCGGCCCCTGGCAGACTGGCTG
CAGAAACACAACCCTGGGGAGGACGAGTATGAGAAGGCTGTGGAGAACTTTATCTACTCC
TGCGCTGGCTGCTGCGTGGCCACGTACGTCTTGGGCATCTGTGACCGACATAATGACAAC
ATCATGCTGAAGACCACTGGTCACATGTTCCACATTGATTTTGGCCGCTTCCTGGGCCAT
GCCCAGATGTTTGGCAACATCAAGCGGGACCGTGCCCCCTTTGTCTTCACCTCGGACATG
GCGTATGTCATCAACGGGGGTGACAAGCCTTCCAGCCGCTTCCATGATTTTGTTGACCTT
TGCTGCCAAGCCTACAACCTCATTCGCAAGCACACCCACCTCTTCCTCAACCTTCTGGGC
CTGATGTTGTCCTGTGGGATCCCTGAACTCTCAGACCTGGAGGACCTCAAGTATGTGTAC
GATGCCCTGAGGCCTCAGGATACAGAGGCCAATGCCACTACCTACTTCACTAGGTTGATT
GAGTCCAGCCTGGGCAGTGTAGCCACAAAGCTCAATTTTTTCATCCATAATCTGGCTCAG
ATGAAGTTCACGGGCTCAGATGACCGGCTGACCCTCTCCTTTGCCTCCCGAACACACACT
CTCAAGAGCTCTGGCCGAATCAGTGATGTTTTCCTCTGCCGCCATGAGAAGATCTTCCAC
CCCAACAAAGGCTATATATATGTGGTAAAGGTGATGCGAGAGAACACTCACGAGGCCACC
TACATCCAGCGGACCTTTGAGGAGTTCCAGGAATTACACAATAAGTTGCGGCTGCTCTTC
CCTTCTTCCCACTTGCCCAGCTTCCCTAGTCGCTTCGTGATCGGCCGCTCCCGGGGAGAG
GCGGTGGCCGAGCGGCGGAGGGAGGAGCTAAACGGTTACATCTGGCACTTGATCCACGCA
CCCCCTGAGGTGGCCGAGTGTGATTTGGTGTACACCTTCTTCCACCCACTGCCCCGGGAT
GAGAAGGCTATGGGCACCAGCCCAGCTCCTAAGTCCTCAGATGGCACATGGGCCCGGCCC
GTCGGAAAGGTGGGAGGGGAGGTGAAGCTGTCCATCTCCTACAAAAACAATAAACTCTTC
ATCATGGTGATGCATATTCGGGGCTTGCAACTGCTCCAGGATGGAAATGACCCTGACCCC
TATGTGAAAATTTACCTCCTTCCTGACCCTCAGAAAACCACTAAGAGGAAAACCAAAGTG
GCCCGGAAAACCTGCAATCCTACCTACAATGAGATGTTGGTATATGATGGGATCCCCAAG
GGTGACCTGCAGCAGCGGGAGCTCCAGCTGAGCGTGCTGAGTGAGCAGGGATTCTGGGAG
AACGTCCTCCTCGGTGAGGTGAACATCCGCCTGCGAGAGCTGGACCTGGCTCAGGAGAAG
ACCGGCTGGTTCGCCCTGGGATCTCGAAGTCATGGCACCTTGTGA

Protein Properties

Number of Residues

1634

Molecular Weight

184766.1

Theoretical pI

7.3

Pfam Domain Function

C2 (PF00168 )
PX (PF00787 )
PI3_PI4_kinase (PF00454 )
PI3K_C2 (PF00792 )
PI3K_rbd (PF00794 )
PI3Ka (PF00613 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Phosphoinositide-3-kinase, class 2, beta polypeptide
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISW
DEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPK
GSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSS
SKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNL
KSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNAT
PGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGY
VWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD
VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQS
PSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAIC
NALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELY
CNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSH
GGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSS
SEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVI
LQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW
EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR
RMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKD
GLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILR
TGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRV
IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK
IQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDN
IMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL
CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI
ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFH
PNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGE
AVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARP
VGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKV
ARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK
TGWFALGSRSHGTL

External Links

GenBank ID Protein

124376922

UniProtKB/Swiss-Prot ID

A2RUF7

UniProtKB/Swiss-Prot Entry Name

A2RUF7_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]