| Identification |
|---|
| HMDB Protein ID
| HMDBP09352 |
| Secondary Accession Numbers
| |
| Name
| Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase |
| Synonyms
|
- NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase
- ST6GalNAc IV
- Sialyltransferase 3C
- Sialyltransferase 7D
- ST6GalNAcIV
- SIAT3-C
- SIAT7-D
|
| Gene Name
| ST6GALNAC4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).
|
| Pathways
|
- Glycosphingolipid biosynthesis - ganglio series
- protein glycosylation
|
| Reactions
|
| Cytidine 5'-monophosphate-N-acetylneuraminic acid + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R → Cytidine monophosphate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R |
details
|
| CMP-N-acetylneuraminate + GM1b → CMP + GD1a |
details
|
|
| GO Classification
|
| Biological Process |
| glycolipid metabolic process |
| O-glycan processing |
| post-translational protein modification |
| Cellular Component |
| Golgi membrane |
| integral to Golgi membrane |
| nucleus |
| Component |
| cell |
| membrane |
| intrinsic to membrane |
| intrinsic to organelle membrane |
| integral to golgi membrane |
| intrinsic to golgi membrane |
| Function |
| sialyltransferase activity |
| catalytic activity |
| transferase activity, transferring glycosyl groups |
| transferase activity |
| Molecular Function |
| sialyltransferase activity |
| (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity |
| Process |
| protein amino acid glycosylation |
| macromolecule metabolism |
| metabolism |
| physiological process |
| protein modification |
| biopolymer modification |
| biopolymer metabolism |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34 |
| SNPs
| Q5T9D0 |
| Gene Sequence
|
>909 bp
ATGAAGGCTCCGGGTCGGCTCGTGCTCATCATCCTGTGCTCCGTGGTCTTCTCTGCCGTC
TACATCCTCCTGTGCTGCTGGGCCGGCCTGCCCCTCTGCCTGGCCACCTGCCTGGACCAC
CACTTCCCCACAGGCTCCAGGCCCACTGTGCCGGGACCCCTGCACTTCAGTGGATATAGC
AGTGTGCCAGATGGGAAGCCGCTGGTCCGCGAGCCCTGCCGCAGCTGTGCCGTGGTGTCC
AGCTCCGGCCAAATGCTGGGCTCAGGCCTGGGTGCTGAGATCGACAGTGCCGAGTGCGTG
TTCCGCATGAACCAGGCGCCCACCGTGGGCTTTGAGGCGGATGTGGGCCAGCGCAGCACC
CTGCGTGTCGTCTCACACACAAGCGTGCCGCTGCTGCTGCGCAACTATTCACACTACTTC
CAGAAGGCCCGAGACACGCTCTACATGGTGTGGGGCCAGGGCAGGCACATGGACCGGGTG
CTCGGCGGCCGCACCTACCGCACGCTGCTGCAGCTCACCAGGATGTACCCCGGCCTGCAG
GTGTACACCTTCACGGAGCGCATGATGGCCTACTGCGACCAGATCTTCCAGGACGAGACG
GGCAAGAACCGGAGGCAGTCGGGCTCCTTCCTCAGCACCGGCTGGTTCACCATGATCCTC
GCGCTGGAGCTGTGTGAGGAGATCGTGGTCTATGGGATGGTCAGCGACAGCTACTGCAGG
GAGAAGAGCCACCCCTCAGTGCCTTACCACTACTTTGAGAAGGGCCGGCTAGATGAGTGT
CAGATGTACCTGGCACACGAGCAGGCGCCCCGAAGCGCCCACCGCTTCATCACTGAGAAG
GCGGTCTTCTCCCGCTGGGCCAAGAAGAGGCCCATCGTGTTCGCCCATCCGTCCTGGAGG
ACTGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 302 |
| Molecular Weight
| 34200.255 |
| Theoretical pI
| 8.569 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ST6 neuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide alpha- 2,6-sialyltransferase 4 (ST6 (Alpha-N-acetyl-neuraminyl-2,3-beta- galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, isoform CRA_a)
MKAPGRLVLIILCSVVFSAVYILLCCWAGLPLCLATCLDHHFPTGSRPTVPGPLHFSGYS
SVPDGKPLVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRST
LRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGRTYRTLLQLTRMYPGLQ
VYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCR
EKSHPSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR
TE
|
| External Links |
|---|
| GenBank ID Protein
| 55958253 |
| UniProtKB/Swiss-Prot ID
| Q9H4F1 |
| UniProtKB/Swiss-Prot Entry Name
| Q5T9D0_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL157935 |
| GeneCard ID
| Q5T9D0 |
| GenAtlas ID
| ST6GALNAC4 |
| HGNC ID
| HGNC:17846 |
| References |
|---|
| General References
| Not Available |
