Hmdb loader
Identification
HMDB Protein ID HMDBP09300
Secondary Accession Numbers
  • 15130
Name E3 ubiquitin-protein ligase MARCH4
Synonyms
  1. MARCH-IV
  2. Membrane-associated RING finger protein 4
  3. Membrane-associated RING-CH protein IV
  4. RING finger protein 174
Gene Name MARCH4
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location
  1. Golgi apparatus membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:2
Locus 2q35
SNPs MARCH4
Gene Sequence
>1233 bp
ATGCTGATGCCCCTGTGTGGGCTGCTCTGGTGGTGGTGGTGCTGCTGCTCCGGCTGGTAC
TGCTATGGATTGTGTGCCCCAGCCCCCCAGATGTTGCGCCACCAGGGTCTCCTCAAGTGC
CGCTGCCGCATGCTCTTCAATGACCTGAAGGTTTTCTTACTGCGGCGCCCTCCTCAAGCG
CCCCTGCCCATGCACGGCGACCCCCAGCCCCCCGGTTTGGCGGCCAACAACACCCTTCCG
GCTCTGGGCGCCGGGGGGTGGGCAGGCTGGAGGGGCCCCCGAGAAGTGGTGGGCAGGGAG
CCCCCTCCTGTGCCACCTCCACCCCCCTTGCCACCTTCTTCTGTGGAAGATGACTGGGGT
GGCCCAGCCACAGAGCCACCTGCCTCGCTGCTCAGCAGTGCCTCCTCAGATGACTTCTGT
AAGGAGAAGACCGAGGATCGCTACTCACTGGGCAGCAGCTTGGACAGTGGTATGAGGACC
CCACTCTGCCGCATCTGCTTCCAGGGGCCAGAACAGGGGGAGCTGCTGAGCCCATGCCGC
TGTGATGGCTCGGTCAAGTGCACACACCAGCCTTGCCTCATCAAGTGGATCAGCGAGCGG
GGCTGCTGGAGCTGCGAGCTGTGCTACTACAAGTACCACGTCATCGCCATAAGCACAAAA
AATCCTCTGCAGTGGCAGGCCATCTCTCTGACGGTCATTGAGAAGGTTCAGGTTGCAGCC
GCCATCCTGGGCTCCCTCTTCCTCATCGCCAGTATTTCTTGGCTCATCTGGTCAACTTTC
AGCCCCTCGGCAAGATGGCAGCGCCAAGACCTTCTCTTCCAGATCTGCTACGGGATGTAT
GGCTTCATGGACGTGGTGTGCATAGGTCTCATCATCCATGAAGGACCCTCGGTGTACCGC
ATCTTTAAACGGTGGCAGGCTGTCAACCAGCAGTGGAAAGTGCTGAACTATGACAAGACA
AAAGACCTGGAGGATCAAAAGGCAGGAGGCAGGACCAACCCCCGGACCTCCTCATCCACC
CAGGCCAATATCCCCTCCTCGGAAGAGGAGACCGCAGGCACCCCTGCCCCTGAGCAGGGC
CCTGCCCAGGCTGCCGGCCACCCCTCAGGCCCTCTGTCCCATCACCACTGTGCTTATACC
ATCCTGCACATCCTGAGTCACTTGAGACCTCATGAACAGCGAAGTCCCCCAGGCAGCAGC
CGAGAGCTGGTCATGAGAGTCACGACAGTGTGA
Protein Properties
Number of Residues 410
Molecular Weight 45528.0
Theoretical pI 7.9
Pfam Domain Function
Signals
  • 1-18
Transmembrane Regions
  • 238-258
  • 272-292
Protein Sequence
>E3 ubiquitin-protein ligase MARCH4
MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQA
PLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWG
GPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCR
CDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQVAA
AILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYR
IFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQG
PAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV
GenBank ID Protein 57977325
UniProtKB/Swiss-Prot ID Q9P2E8
UniProtKB/Swiss-Prot Entry Name MARH4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_020814.2
GeneCard ID MARCH4
GenAtlas ID MARCH4
HGNC ID HGNC:29269
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [PubMed:10718198 ]
  3. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K: Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol. 2004 Feb;78(3):1109-20. [PubMed:14722266 ]