Hmdb loader
Identification
HMDB Protein ID HMDBP09027
Secondary Accession Numbers
  • 14769
Name Putative methyltransferase NSUN5
Synonyms
  1. NOL1-related protein
  2. NOL1/NOP2/Sun domain family member 5
  3. NOL1R
  4. Williams-Beuren syndrome chromosomal region 20A protein
Gene Name NSUN5
Protein Type Unknown
Biological Properties
General Function Translation, ribosomal structure and biogenesis
Specific Function May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential)
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:7
Locus 7q11.23
SNPs NSUN5
Gene Sequence
>1290 bp
ATGGGGCTGTATGCTGCAGCTGCAGGCGTGTTGGCCGGCGTGGAGAGCCGCCAGGGCTCT
ATCAAGGGGTTGGTGTACTCCAGCAACTTCCAGAACGTGAAGCAGCTGTACGCGCTGGTG
TGCGAAACGCAGCGCTACTCCGCCGTGCTGGATGCTGTGATCGCCAGCGCCGGCCTCCTC
CGTGCGGAGAAGAAGCTGCGGCCGCACCTGGCCAAGGTGCTAGTGTATGAGTTGTTGTTG
GGAAAGGGCTTTCGAGGGGGTGGGGGCCGATGGAAGGCTCTGTTGGGCCGGCACCAGGCG
AGGCTCAAGGCTGAGTTGGCTCGGCTCAAGGTTCATCGGGGTGTGAGCCGGAATGAGGAC
CTGTTGGAAGTGGGATCCAGGCCTGGTCCAGCCTCCCAGCTGCCTCGATTTGTGCGTGTG
AACACTCTCAAGACCTGCTCCGATGATGTAGTTGATTATTTCAAGAGACAAGGTTTCTCC
TATCAGGGTCGGGCTTCCAGCCTCGATGACTTACGAGCCCTCAAGGGGAAGCATTTTCTC
CTGGACCCCTTGATGCCGGAGCTGCTGGTGTTTCCCGCCCAGACAGATCTGCATGAACAC
CCACTGTACCGGGCCGGACACCTCATTCTGCAGGACAGGGCCAGCTGTCTCCCAGCCATG
CTGCTGGACCCCCCGCCAGGCTCCCATGTCATCGATGCCTGTGCCGCCCCAGGCAATAAG
ACCAGTCACTTGGCTGCTCTTCTGAAGAACCAAGGGAAGATCTTTGCCTTTGACCTGGAT
GCCAAGCGGCTGGCATCCATGGCCACGCTGCTGGCCCGGGCTGGCGTCTCTTGCTGTGAA
CTGGCTGAGGAGGACTTCCTGGCGGTCTCCCCCTCGGATCCACGCTACCATGAGGTCCAC
TACATCCTGCTGGATCCTTCCTGCAGTGGCTCGGGTATGCCGAGCAGACAGCTGGAGGAG
CCCGGGGCAGGCACACCTAGCCCGGTGCGTCTGCATGCCCTGGCAGGGTTCCAGCAGCGA
GCCCTGTGCCACGCGCTCACTTTCCCTTCCCTGCAGCGGCTCGTCTACTCCACGTGCTCC
CTCTGCCAGGAGGAGAATGAAGACGTGGTGCGAGATGCGCTGCAGCAGAACCCGGGCGCC
TTCAGGCTAGCTCCCGCCCTGCCTGCCTGGCCCCACCGAGGCCTGAGCACGTTCCCGGGT
GCCGAGCACTGCCTCCGGGCCTCCCCTGAGACCACACTCAGCAGTGGCTTCTTCGTTGCT
GTAATTGAACGGGTCGAGGTGCCAAGGTGA
Protein Properties
Number of Residues 429
Molecular Weight 46691.2
Theoretical pI 8.73
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Putative methyltransferase NSUN5
MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLL
RAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNED
LLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFSYQGRASSLDDLRALKGKHFL
LDPLMPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNK
TSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSPSDPRYHEVH
YILLDPSCSGSGMPSRQLEEPGAGTPSPVRLHALAGFQQRALCHALTFPSLQRLVYSTCS
LCQEENEDVVRDALQQNPGAFRLAPALPAWPHRGLSTFPGAEHCLRASPETTLSSGFFVA
VIERVEVPR
GenBank ID Protein 37674385
UniProtKB/Swiss-Prot ID Q96P11
UniProtKB/Swiss-Prot Entry Name NSUN5_HUMAN
PDB IDs Not Available
GenBank Gene ID AC073841
GeneCard ID NSUN5
GenAtlas ID NSUN5
HGNC ID HGNC:16385
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
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  8. Doll A, Grzeschik KH: Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome. Cytogenet Cell Genet. 2001;95(1-2):20-7. [PubMed:11978965 ]