Human Metabolome Database: Showing Protein Receptor-type tyrosine-protein phosphatase T (HMDBP08951)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP08951

Secondary Accession Numbers

14680

Name

Receptor-type tyrosine-protein phosphatase T

Synonyms

R-PTP-T
RPTP-rho
Receptor-type tyrosine-protein phosphatase rho

Gene Name

PTPRT

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

May be involved in both signal transduction and cellular adhesion in the CNS.

Pathways

Not Available

Reactions

Protein tyrosine phosphate + Water → protein tyrosine + Phosphate

details

GO Classification

Biological Process
homophilic cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
cell surface
plasma membrane
integral to membrane
Component
membrane
cell part
Function
protein tyrosine phosphatase activity
phosphoprotein phosphatase activity
phosphatase activity
phosphoric ester hydrolase activity
hydrolase activity, acting on ester bonds
hydrolase activity
catalytic activity
Molecular Function
gamma-catenin binding
alpha-catenin binding
thiolester hydrolase activity
protein tyrosine phosphatase activity
Process
protein amino acid dephosphorylation
dephosphorylation
phosphate metabolic process
phosphorus metabolic process
cellular metabolic process
metabolic process

Cellular Location

Membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Locus

20q12-q13

SNPs

PTPRT

Gene Sequence

>4392 bp
ATGGCGAGCCTCGCCGCGCTCGCCCTCAGCCTGCTCCTGAGGCTGCAGCTGCCGCCACTG
CCCGGCGCCCGGGCTCAGAGCGCCCCAGGTGGCTGTTCCTTTGATGAGCACTACAGCAAC
TGTGGTTATAGTGTGGCTCTAGGGACCAATGGGTTCACCTGGGAGCAGATTAACACAACG
GAGAAACCAATGCTGGACCAGGCAGTGCCCACAGGATCTTTCATGATGGTGAACAGCTCT
GGGAGAGCCTCTGGCCAGAAGGCCCACCTTCTCCTGCCAACCCTGAAGGAGAATGACACC
CACTGCATCGACTTCCATTACTACTTCTCCAGCCGTGACAGGTCCAGCCCAGGGGCCTTG
AACGTCTACGTGAAGGTGAATGGTGGCCCCCAAGGGAACCCTGTGTGGAATGTGTCCGGG
GTCGTCACTGAGGGCTGGGTGAAGGCAGAGCTCGCCATCAGCACTTTCTGGCCACATTTC
TATCAGGTGATATTTGAATCCGTCTCATTGAAGGGTCATCCTGGCTACATCGCCGTGGAC
GAGGTCCGGGTCCTTGCTCATCCATGCAGAAAAGCACCTCATTTTCTGCGACTCCAAAAC
GTGGAGGTGAATGTGGGGCAGAATGCCACATTTCAGTGCATTGCTGGTGGGAAGTGGTCT
CAGCATGACAAGCTTTGGCTCCAGCAATGGAATGGCAGGGACACGGCCCTGATGGTCACC
CGTGTGGTCAACCACAGGCGCTTCTCAGCCACAGTCAGTGTGGCAGACACTGCCCAGCGG
AGCGTCAGCAAGTACCGCTGTGTGATCCGCTCTGATGGTGGGTCTGGTGTGTCCAACTAC
GCGGAGCTGATCGTGAAAGAGCCTCCCACGCCCATTGCTCCCCCAGAGCTGCTGGCTGTG
GGGGCCACATACCTGTGGATCAAGCCAAATGCCAACTCCATCATCGGGGATGGCCCCATC
ATCCTGAAGGAAGTGGAATATCGCACCACCACAGGCACGTGGGCAGAGACCCACATAGTC
GACTCTCCCAACTATAAGCTGTGGCATCTGGACCCCGATGTTGAGTATGAGATCCGAGTG
CTCCTCACACGACCAGGTGAGGGGGGTACGGGACCGCCAGGGGCTCCCCTCACCACCAGG
ACCAAGTGTGCAGATCCGGTACATGGCCCACAGAACGTGGAAATCGTAGACATCAGAGCC
CGGCAGCTGACCCTGCAGTGGGAGCCCTTCGGCTACGCGGTGACCCGCTGCCATAGCTAC
AACCTCACCGTGCAGTACCAGTATGTGTTCAACCAGCAGCAGTACGAGGCCGAGGAGGTC
ATCCAGACCTCCTCCCACTACACCCTGCGAGGCCTGCGCCCCTTCATGACCATCCGGCTG
CGACTCTTGCTGTCTAACCCCGAGGGCCGAATGGAGAGCGAGGAGCTGGTGGTGCAGACT
GAGGAAGACGTTCCAGGAGCTGTTCCTCTAGAATCCATCCAAGGGGGGCCCTTTGAGGAG
AAGATCTACATCCAGTGGAAACCTCCCAATGAGACCAATGGGGTCATCACGCTCTACGAG
ATCAACTACAAGGCTGTCGGCTCGCTGGACCCAAGTGCTGACCTCTCGAGCCAGAGGGGG
AAAGTGTTCAAGCTCCGGAATGAAACCCACCACCTCTTTGTGGGTCTGTACCCAGGGACC
ACCTATTCCTTCACCATCAAGGCCAGCACAGCAAAGGGCTTTGGGCCCCCTGTCACCACT
CGGATTGCCACCAAAATTTCAGCTCCATCCATGCCTGAGTACGACACAGACACCCCATTG
AATGAGACAGACACGACCATCACAGTGATGCTGAAACCCGCTCAGTCCCGGGGAGCTCCT
GTCAGTGTTTATCAGCTGGTTGTCAAGGAGGAGCGACTTCAGAAGTCACGGAGGGCAGCT
GACATTATTGAGTGCTTTTCGGTGCCCGTGAGCTATCGGAATGCCTCCAGCCTCGATTCT
CTACACTACTTTGCTGCTGAGTTGAAGCCTGCCAACCTGCCTGTCACCCAGCCATTTACA
GTGGGTGACAATAAGACATACAATGGCTACTGGAACCCTCCTCTCTCTCCCCTGAAAAGC
TACAGCATCTACTTCCAGGCACTCAGCAAAGCCAATGGAGAGACCAAAATCAACTGTGTT
CGTCTGGCTACAAAAGCACCAATGGGCAGCGCCCAGGTGACCCCGGGGACTCCACTCTGC
CTCCTCACCACAGGTGCCTCCACCCAGAATTCTAACACTGTGGAGCCAGAGAAGCAGGTG
GACAACACCGTGAAGATGGCTGGCGTGATCGCTGGCCTCCTCATGTTCATCATCATTCTC
CTGGGCGTGATGCTCACCATCAAAAGGAGAAGAAATGCTTATTCCTACTCCTATTACTTG
TCCCAAAGGAAGCTGGCCAAGAAGCAGAAGGAGACCCAGAGTGGAGCCCAGAGGGAGATG
GGGCCTGTGGCCTCTGCCGACAAACCCACCACCAAGCTCAGCGCCAGCCGCAATGATGAA
GGCTTCTCTTCTAGTTCTCAGGACGTCAACGGATTCACAGATGGCAGCCGCGGGGAGCTT
TCCCAGCCCACCCTCACGATCCAGACTCATCCCTACCGCACCTGTGACCCTGTGGAGATG
AGCTACCCCCGGGACCAGTTCCAACTCGCCATCCGGGTGGCTGACTTGCTGCAGCACATC
ACGCAGATGAAGAGAGGCCAGGGCTACGGGTTCAAGGAGGAATACGAGGCCTTACCAGAG
GGGCAGACAGCTTCGTGGGACACAGCCAAGGAGGATGAAAACCGCAATAAGAATCGATAT
GGGAACATCATATCCTACGACCATTCCCGGGTGAGGCTGCTGGTGCTGGATGGAGACCCG
CACTCTGACTACATCAATGCCAACTACATTGACGGATACCATCGACCTCGGCACTACATT
GCGACTCAAGGTCCGATGCAGGAGACTGTAAAGGACTTTTGGAGAATGATCTGGCAGGAG
AACTCCGCCAGCATCGTCATGGTCACAAACCTGGTGGAAGTGGGCAGGGTGAAATGTGTG
CGATACTGGCCAGATGACACGGAGGTCTACGGAGACATTAAAGTCACCCTGATTGAAACA
GAGCCCCTGGCAGAATACGTCATACGCACCTTCACAGTCCAGAAGAAAGGCTACCATGAG
ATCCGGGAGCTCCGCCTCTTCCACTTCACCAGCTGGCCTGACCACGGCGTTCCCTGCTAT
GCCACTGGCCTTCTGGGCTTCGTCCGCCAGGTCAAGTTCCTCAACCCCCCGGAAGCTGGG
CCCATAGTGGTCCACTGCAGTGCTGGGGCTGGGCGGACTGGCTGCTTCATTGCCATTGAC
ACCATGCTTGACATGGCCGAGAATGAAGGGGTGGTGGACATCTTCAACTGCGTGCGTGAG
CTCCGGGCCCAAAGGGTCAACCTGGTACAGACAGAGGAGCAATATGTGTTTGTGCACGAT
GCCATCCTGGAAGCGTGCCTCTGTGGCAACACTGCCATCCCTGTGTGTGAGTTCCGTTCT
CTCTACTACAATATCAGCAGGCTGGACCCCCAGACAAACTCCAGCCAAATCAAAGATGAA
TTTCAGACCCTCAACATTGTGACACCCCGTGTGCGGCCCGAGGACTGCAGCATTGGGCTC
CTGCCCCGGAACCATGATAAGAATCGAAGTATGGACGTGCTGCCTCTGGACCGCTGCCTG
CCCTTCCTTATCTCAGTGGACGGAGAATCCAGCAATTACATCAACGCAGCACTGATGGAT
AGCCACAAGCAGCCTGCCGCCTTCGTGGTCACCCAGCACCCTCTACCCAACACCGTGGCA
GACTTCTGGAGGCTGGTGTTCGATTACAACTGCTCCTCTGTGGTGATGCTGAATGAGATG
GACACTGCCCAGTTCTGTATGCAGTACTGGCCTGAGAAGACCTCCGGGTGCTATGGGCCC
ATCCAGGTGGAGTTCGTCTCCGCAGACATCGACGAGGACATCATCCACAGAATATTCCGC
ATCTGTAACATGGCCCGGCCACAGGATGGTTATCGTATAGTCCAGCACCTCCAGTACATT
GGCTGGCCTGCCTACCGGGACACGCCCCCCTCCAAGCGCTCTCTGCTCAAAGTGGTCCGA
CGACTGGAGAAGTGGCAGGAGCAGTATGACGGGAGGGAGGGACGTACTGTGGTCCACTGC
CTAAATGGGGGAGGCCGTAGTGGAACCTTCTGTGCCATCTGCAGTGTGTGTGAGATGATC
CAGCAGCAAAACATCATTGACGTGTTCCACATCGTGAAAACACTGCGTAACAACAAATCC
AACATGGTGGAGACCCTGGAACAGTATAAATTTGTATACGAGGTGGCACTGGAATATTTA
AGCTCCTTTTAG

Protein Properties

Number of Residues

1463

Molecular Weight

162132.92

Theoretical pI

6.893

Pfam Domain Function

fn3 (PF00041 )
MAM (PF00629 )
Y_phosphatase (PF00102 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Receptor-type tyrosine-protein phosphatase T
MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL
LGVMLTIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDE
GFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHI
TQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDP
HSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCV
RYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCY
ATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRE
LRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDE
FQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMD
SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGP
IQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVR
RLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKS
NMVETLEQYKFVYEVALEYLSSF

External Links

GenBank ID Protein

6554165

UniProtKB/Swiss-Prot ID

O14522

UniProtKB/Swiss-Prot Entry Name

PTPRT_HUMAN

PDB IDs

2OOQ

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

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Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N: Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. DNA Res. 1997 Feb 28;4(1):53-9. [PubMed:9179496 ]
McAndrew PE, Frostholm A, White RA, Rotter A, Burghes AH: Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. Brain Res Mol Brain Res. 1998 May;56(1-2):9-21. [PubMed:9602027 ]
Besco JA, Frostholm A, Popesco MC, Burghes AH, Rotter A: Genomic organization and alternative splicing of the human and mouse RPTPrho genes. BMC Genomics. 2001;2:1. Epub 2001 Jun 8. [PubMed:11423001 ]
Besco JA, Frostholm A, Popesco MC, Burghes AH, Rotter A: Genomic organization and alternative splicing of the human and mouse RPTPrho genes: Correction. BMC Genomics. 2001;2:5. Epub 2001 Aug 14. [PubMed:11814386 ]
Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE: Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science. 2004 May 21;304(5674):1164-6. [PubMed:15155950 ]