Human Metabolome Database: Showing Protein Tyrosine-protein phosphatase non-receptor type 21 (HMDBP08932)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP08932

Secondary Accession Numbers

14661

Name

Tyrosine-protein phosphatase non-receptor type 21

Synonyms

Protein-tyrosine phosphatase D1

Gene Name

PTPN21

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Not Available

Pathways

Not Available

Reactions

Protein tyrosine phosphate + Water → protein tyrosine + Phosphate

details

GO Classification

Cellular Component
cytoskeleton
cytoplasm
Component
cytoskeleton
intracellular non-membrane-bounded organelle
non-membrane-bounded organelle
organelle
Function
binding
protein tyrosine phosphatase activity
phosphoprotein phosphatase activity
phosphatase activity
phosphoric ester hydrolase activity
hydrolase activity
catalytic activity
hydrolase activity, acting on ester bonds
Molecular Function
protein tyrosine phosphatase activity
Process
cellular metabolic process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process

Cellular Location

Cytoplasm
cytoskeleton

Gene Properties

Chromosome Location

Locus

14q31.3

SNPs

PTPN21

Gene Sequence

>3525 bp
ATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAG
AGTTGCCTGGTTGCCCGGATCCAACTGCTTAATAACGAGTTTGTGGAGTTCACCCTGTCC
GTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGTGGCCCAGAGGCTGGAGCTGCGGGAG
GTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTG
GAAAAACCTTTGAAGAAGCAGCTGGATAAATATGCATTGGAACCTACCGTCTATTTTGGA
GTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCAGCAGGAGATTACCAGGTATCAGTAT
TATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCA
ATTCAGCTAGCAGGCTTAGCTGTTCAAGCGGATTTTGGTGACTTTGATCAGTATGAATCC
CAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGTGGGATGGTTACAAGATGAAAAAGTA
TTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCT
CCTGATGCTGAAATGCTGTACATGCAGGAGGTAGAGAGAATGGATGGCTATGGAGAAGAG
AGCTACCCTGCTAAGGATAGCCAAGGAAGTGACATATCCATTGGAGCGTGTCTTGAAGGT
ATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCC
AACATGTCCCACAACAAGTCCTTTTTTGCATTAGAGCTGGCAAATAAAGAGGAGACCATT
CAATTTCAAACTGAAGACATGGAAACAGCAAAATACATTTGGAGACTCTGTGTTGCGCGA
CACAAGTTTTACAGACTAAACCAGTGTAACCTGCAAACTCAGACTGTCACAGTGAACCCA
ATCAGGAGGAGGTCTTCTTCAAGGATGTCTCTGCCTAAACCCCAGCCCTACGTGATGCCT
CCCCCACCGCAGTTGCACTATAATGGACATTATACAGAACCATATGCTTCTTCCCAAGAT
AACCTCTTTGTGCCCAACCAGAACGGATACTACTGTCACTCTCAGACAAGCTTGGATAGA
GCCCAGATTGACTTCAACGGTCGGATCCGTAATGGCAGTGTCTACAGTGCACACAGCACC
AACTCCTTAAATAATCCTCAGCCCTACTTGCAGCCCTCGCCGATGTCGTCCAACCCTAGC
ATCACCGGGAGTGACGTCATGAGGCCTGACTACCTCCCGTCCCATCGGCACAGCGCCGTG
ATACCCCCGTCCTACCGCCCCACCCCAGACTATGAGACTGTGATGAAGCAGCTCAACAGG
GGCCTGGTGCATGCGGAACGGCAGAGCCACTCGCTGCGAAACCTCAACATCGGCAGCTCG
TACGCCTACAGCAGGCCCGCGGCGCTGGTCTACAGCCAGCCCGAGATCCGCGAGCACGCA
CAGCTCCCCTCGCCAGCGGCCGCACACTGCCCGTTCAGCCTGAGCTACAGCTTCCACAGC
CCGTCTCCCTACCCCTACCCTGCCGAGCGGCGGCCCGTGGTGGGCGCGGTCAGCGTGCCG
GAGCTGACCAATGCGCAGCTGCAGGCGCAGGACTACCCGTCTCCCAACATCATGCGGACG
CAGGTGTACCGGCCACCCCCACCCTACCCGCCCCCCAGGCCCGCCAACAGCACGCCAGAC
CTGTCCCGCCACCTTTACATCAGCAGCAGCAACCCCGACCTCATCACGCGGCGCGTGCAC
CACTCGGTGCAAACGTTCCAGGAGGACAGCCTGCCCGTGGCGCACTCGCTGCAGGAGGTC
AGCGAGCCCCTCACCGCCGCGCGCCACGCGCAGCTGCACAAACGGAACAGCATCGAGGTG
GCCGGGCTCAGCCACGGCCTGGAGGGCCTGCGGCTCAAGGAGCGCACCCTATCCGCGTCG
GCGGCAGAGGTGGCGCCGCGAGCCGTCTCGGTGGGCTCCCAGCCCAGCGTTTTCACCGAG
AGGACACAGCGAGAAGGGCCGGAGGAGGCGGAGGGCTTGAGGTACGGCCATAAGAAGTCC
CTGTCGGACGCCACCATGCTAATCCACAGCAGCGAGGAGGAGGAGGACGAGGACTTCGAG
GAGGAGAGCGGGGCCCGGGCGCCCCCTGCACGTGCGCGCGAGCCTCGGCCCGGCCTGGCC
CAGGACCCACCTGGCTGCCCTCGCGTCCTGCTCGCCGGGCCCCTGCACATCCTGGAGCCC
AAGGCCCACGTCCCAGACGCGGAGAAGAGGATGATGGACAGCAGCCCCGTCCGCACGACC
GCAGAGGCCCAGCGGCCCTGGAGAGACGGGCTGCTGATGCCCTCCATGTCGGAGTCCGAC
CTCACCACGTCAGGCCGCTACCGAGCCCGGAGGGACTCTCTGAAGAAAAGGCCGGTGTCG
GACCTTCTCTCTGGGAAGAAGAACATCGTGGAAGGGCTCCCGCCTCTAGGGGGAATGAAA
AAGACTCGAGTAGATGCAAAAAAAATTGGTCCTCTTAAACTGGCTGCCCTAAATGGACTC
TCCCTATCTCGAGTGCCTCTGCCTGATGAAGGAAAGGAAGTGGCTACCAGAGCAACGAAT
GATGAAAGGTGTAAAATTCTGGAACAACGATTAGAACAAGGAATGGTATTCACAGAATAT
GAAAGAATTCTTAAGAAACGGCTAGTTGATGGGGAGTGCTCAACAGCACGACTCCCTGAA
AATGCAGAAAGAAATCGATTCCAAGATGTTCTTCCTTATGATGATGCGAGAGTGGAGTTG
GTCCCAACTAAAGAAAACAACACTGGTTACATCAACGCATCACATATTAAGGTCTCTGTC
AGTGGAATCGAATGGGATTATATTGCCACACAGGGACCATTACAGAATACCTGTCAAGAT
TTTTGGCAGATGGTATGGGAACAGGGAATTGCAATTATAGCAATGGTGACAGCAGAAGAG
GAGGGTGGAAGGGAGAAGAGCTTTAGGTACTGGCCACGACTTGGTTCCAGGCACAACACT
GTCACCTATGGAAGGTTTAAGATCACGACCCGGTTCCGCACAGACTCTGGCTGCTATGCC
ACCACAGGCCTGAAGATGAAGCACCTCCTTACCGGGCAAGAGAGGACCGTCTGGCACCTC
CAATACACAGACTGGCCTGAACATGGCTGTCCAGAAGACCTCAAGGGATTTTTATCATAT
CTTGAAGAGATCCAGTCTGTTCGACGCCATACAAATAGCACAAGTGATCCCCAAAGCCCC
AACCCTCCGTTGTTGGTCCACTGCAGTGCTGGGGTAGGAAGGACTGGCGTGGTGATTTTG
TCGGAGATCATGATCGCCTGCCTGGAACACAATGAGGTGCTGGACATCCCGAGAGTGCTG
GACATGCTGAGGCAACAGAGAATGATGCTGGTGCAGACTCTCTGCCAGTACACATTTGTG
TACAGAGTCCTCATCCAGTTCCTGAAAAGCTCCAGGCTCATCTAA

Protein Properties

Number of Residues

1174

Molecular Weight

133279.965

Theoretical pI

7.897

Pfam Domain Function

FERM_M (PF00373 )
Y_phosphatase (PF00102 )
FERM_C (PF09380 )
FERM_N (PF09379 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Tyrosine-protein phosphatase non-receptor type 21
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE
VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY
YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG
IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR
HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD
NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS
ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS
YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP
ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH
HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS
AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE
EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT
AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK
KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY
ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV
SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT
VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY
LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL
DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI

External Links

GenBank ID Protein

532056

UniProtKB/Swiss-Prot ID

Q16825

UniProtKB/Swiss-Prot Entry Name

PTN21_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [PubMed:12508121 ]
Moller NP, Moller KB, Lammers R, Kharitonenkov A, Sures I, Ullrich A: Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7477-81. [PubMed:7519780 ]