Hmdb loader
Identification
HMDB Protein ID HMDBP08891
Secondary Accession Numbers
  • 14619
Name Thioredoxin domain-containing protein 2
Synonyms
  1. Spermatid-specific thioredoxin-1
  2. Sptrx-1
Gene Name TXNDC2
Protein Type Enzyme
Biological Properties
General Function Involved in nutrient reservoir activity
Specific Function Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase
Pathways Not Available
Reactions Not Available
GO Classification
Process
cellular process
cellular homeostasis
cell redox homeostasis
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs TXNDC2
Gene Sequence
>1662 bp
ATGGATGTAGACAAGGAACTAGGAATGGAAAGTGTTAAAGCTGGAGCCTCTGGAAAACCA
GAAATGAGGCTGGGCACTCAGGAAGAAACAAGTGAAGGTGATGCTAATGAAAGCTCATTA
CTAGTCCTGTCCAGCAACGTGCCTCTCCTGGCCCTAGAGTTCTTGGAAATAGCCCAGGCC
AAAGAGAAGGCCTTTCTCCCCATGGTCAGCCACACGTTCCACATGCGCACAGAGGAGTCT
GATGCCTCACAGGAGGGCGATGACCTACCCAAGTCCTCAGCAAACACCAGCCATCCCAAG
CAGGATGACAGCCCCAAGTCCTCAGAAGAAACCATCCAGCCCAAGGAGGGTGACATCCCC
AAGGCCCCAGAAGAAACCATCCAATCCAAGAAGGAGGACCTCCCCAAGTCCTCAGAAAAA
GCCATCCAGCCCAAAGAGAGTAACATCCCCAAGTCCTCAGCAAAACCCATCCAGCCCAAG
CTGGGCAATATTCCCAAGGCCTCAGTGAAGCCCAGCCAGCCCAAGGAGGGTGACATCCCC
AAGGCCCCAGAAGAAACCATCCAATCCAAGAAGGAGGACCTCCCCAAGTCCTCAGAAGAA
GCCATCCAGCCCAAAGAGGGTGACATCCCCAAGTCCTCAGCAAAACCCATCCAGCCCAAG
CTGGGCAATATTGCCAAGACCTCAGTGAAGCCCAGCCAGCCCAAGGAGAGTGATATCCCC
AAGTCCCCAGAAGAAACCATCCAGCCCAAGGAGGGTGACATCCCCAAGTCCTCAGCAAAG
CCCATCCAGCCCAAGCTGGGCAATATTCCCAAGGCCTCAGTGAAGCCCAGCCAGCCCAAG
GAGGGTGACATCTCCAAGTCCCCAGAAGAAGCCATCCAGCCCAAGGAGGGTGACCTCCCC
AAGTCCCTAGAGGAAGCCATCCAGCCCAAGGAGGGTGACATCCCCAAGTCCCCAGAAGAA
GCCATCCAGCCCAAGGAGGGTGACATCCCCAAGTCCCTAGAGGAAGCCATCCAGCCTAAG
GAGGGTGACATCCCCAAGTCCCCAGAAGAAACCATCCAGCCCAAGAAGGGTGACATCCCC
AAGTCCCCAGAAGAAGCCATCCAGCCCAAGGAGGGTGACATTCCCAAGTCTCCAAAACAA
GCCATCCAGCCCAAGGAGGGTGACATTCCCAAGTCCCTAGAGGAAGCCATCCCACCCAAG
GAGATTGACATCCCCAAGTCCCCAGAAGAAACCATCCAGCCCAAGGAGGATGACAGCCCC
AAGTCCCTAGAAGAAGCCACCCCATCCAAGGAGGGTGACATCCTAAAGCCTGAAGAAGAA
ACAATGGAGTTCCCGGAGGGGGACAAGGTGAAAGTGATCCTGAGCAAGGAGGACTTTGAG
GCATCACTGAAGGAGGCCGGGGAGAGGCTGGTGGCTGTGGACTTCTCGGCCACGTGGTGT
GGGCCCTGCAGGACCATCAGACCATTCTTCCATGCCCTGTCTGTGAAGCATGAGGATGTG
GTGTTCCTGGAGGTGGACGCTGACAACTGTGAGGAGGTGGTGAGAGAGTGCGCCATCATG
TGTGTCCCAACCTTTCAGTTTTATAAAAAAGAAGAAAAGGTGGATGAACTTTGCGGCGCC
CTTAAGGAAAAACTTGAAGCAGTCATTGCAGAATTAAAGTAA
Protein Properties
Number of Residues 553
Molecular Weight 60461.5
Theoretical pI 4.5
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Thioredoxin domain-containing protein 2
MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQA
KEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP
KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP
KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP
KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP
KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKDDIP
KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSP
KSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWC
GPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGA
LKEKLEAVIAELK
GenBank ID Protein 148727319
UniProtKB/Swiss-Prot ID Q86VQ3
UniProtKB/Swiss-Prot Entry Name TXND2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001098529.1
GeneCard ID TXNDC2
GenAtlas ID TXNDC2
HGNC ID HGNC:16470
References
General References
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  3. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
  4. Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [PubMed:16177791 ]
  5. Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G: Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa. J Biol Chem. 2001 Aug 24;276(34):31567-74. Epub 2001 Jun 8. [PubMed:11399755 ]
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