Human Metabolome Database: Showing Protein TCDD-inducible poly [ADP-ribose] polymerase (HMDBP08876)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP08876

Secondary Accession Numbers

14603

Name

TCDD-inducible poly [ADP-ribose] polymerase

Synonyms

PARP-7
Poly [ADP-ribose] polymerase 7
ADP-ribosyltransferase diphtheria toxin-like 14
ARTD14

Gene Name

TIPARP

Protein Type

Unknown

Biological Properties

General Function

Involved in NAD+ ADP-ribosyltransferase activity

Specific Function

Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Pathways

Not Available

Reactions

NAD + (ADP-D-ribosyl)(n)-acceptor → Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor

details

GO Classification

Biological Process
hemopoiesis
vasculogenesis
smooth muscle tissue development
platelet-derived growth factor receptor signaling pathway
multicellular organismal metabolic process
female gonad development
protein ADP-ribosylation
skeletal system morphogenesis
estrogen metabolic process
nitrogen compound metabolic process
palate development
face morphogenesis
kidney development
androgen metabolic process
post-embryonic development
Function
nucleic acid binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
zinc ion binding
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
nad+ adp-ribosyltransferase activity
ion binding
Molecular Function
NAD+ ADP-ribosyltransferase activity
nucleic acid binding
metal ion binding
zinc ion binding

Cellular Location

Cytoplasmic

Gene Properties

Chromosome Location

Locus

3q25.31

SNPs

TIPARP

Gene Sequence

>1974 bp
ATGGAAATGGAAACCACCGAACCTGAGCCAGACTGTGTAGTGCAGCCTCCCTCTCCTCCT
GATGACTTTTCATGCCAAATGAGACTCTCTGAGAAGATCACTCCATTGAAGACTTGTTTT
AAGAAAAAGGATCAGAAAAGATTGGGAACTGGAACCCTGAGGTCTTTGAGGCCAATATTA
AACACTCTTCTAGAATCTGGCTCACTTGATGGGGTTTTTAGATCTAGGAACCAGAGTACA
GATGAGAACAGCTTACATGAACCTATGATGAAGAAAGCCATGGAAATCAATTCATCATGC
CCACCAGCAGAAAATAATATGTCTGTTCTGATTCCTGATAGGACAAATGTTGGGGACCAG
ATACCGGAAGCCCATCCTTCCACTGAAGCTCCAGAACGAGTGGTTCCAATCCAAGATCAC
AGCTTTCCATCAGAAACCCTCAGTGGGACGGTGGCAGATTCCACACCAGCTCACTTCCAG
ACTGATCTTTTGCACCCAGTTTCAAGTGATGTTCCTACTAGTCCTGACTGCTTAGACAAA
GTCATAGATTATGTTCCAGGCATTTTCCAAGAAAACAGTTTTACAATCCAATACATTCTG
GACACCAGTGATAAGCTGAGTACTGAGCTCTTTCAGGACAAAAGTGAAGAGGCTTCCCTT
GACCTCGTGTTTGAGCTGGTGAACCAGTTGCAGTACCACACTCACCAAGAGAACGGAATT
GAAATTTGCATGGACTTTCTGCAAGGCACTTGTATTTATGGCAGGGATTGTTTGAAGCAC
CACACTGTCTTGCCATATCATTGGCAGATCAAAAGGACAACTACTCAAAAGTGGCAGAGT
GTATTCAATGATTCTCAGGAGCACTTGGAAAGATTTTACTGTAACCCAGAAAATGATAGA
ATGAGAATGAAGTATGGAGGACAAGAATTTTGGGCAGATTTGAATGCCATGAACGTGTAT
GAAACAACTGAATTTGACCAACTACGAAGGCTGTCCACACCACCCTCTAGCAATGTCAAC
TCTATTTACCACACAGTCTGGAAATTCTTCTGTAGGGACCACTTTGGATGGAGAGAGTAT
CCCGAGTCTGTCATTCGATTGATTGAAGAAGCCAACTCTCGGGGTCTGAAAGAGGTTCGA
TTTATGATGTGGAATAACCACTACATCCTCCACAATTCATTCTTCAGGAGAGAGATAAAA
AGGAGACCCCTCTTCCGCTCCTGTTTTATACTGCTTCCATATTTACAGACACTTGGTGGG
GTTCCCACACAAGCTCCTCCACCTCTTGAAGCAACTTCATCATCACAAATTATCTGCCCA
GATGGGGTCACTTCAGCAAACTTTTACCCTGAAACTTGGGTTTATATGCATCCATCTCAG
GACTTCATCCAAGTCCCTGTTTCTGCAGAGGATAAAAGTTATCGGATCATTTACAATCTT
TTTCATAAGACTGTGCCTGAGTTTAAATACAGAATTTTGCAGATATTGAGAGTCCAAAAC
CAGTTTCTTTGGGAGAAATATAAAAGGAAAAAGGAATATATGAACAGGAAAATGTTTGGC
CGTGACAGGATAATAAATGAGAGACATTTATTTCATGGAACATCCCAGGATGTGGTAGAT
GGAATCTGCAAACACAACTTTGACCCTCGAGTCTGTGGAAAGCATGCTACAATGTTTGGA
CAAGGCAGTTATTTTGCAAAGAAGGCAAGCTACTCTCATAACTTTTCTAAGAAGTCCTCC
AAAGGAGTCCACTTCATGTTTCTGGCCAAAGTGCTGACGGGCAGATACACAATGGGCAGT
CATGGCATGAGAAGGCCCCCGCCAGTCAATCCTGGCAGTGTCACCAGTGACCTTTATGAC
TCTTGTGTGGATAATTTCTTTGAGCCTCAGATTTTTGTCATTTTTAATGATGACCAGAGT
TACCCTTATTTTGTTATCCAATATGAAGAAGTCAGTAACACTGTTTCCATTTGA

Protein Properties

Number of Residues

657

Molecular Weight

76226.74

Theoretical pI

6.658

Pfam Domain Function

PARP (PF00644 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>TCDD-inducible poly [ADP-ribose] polymerase
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL
NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ
IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK
VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI
EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY
PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG
VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL
FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD
GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI

External Links

GenBank ID Protein

296080688

UniProtKB/Swiss-Prot ID

Q7Z3E1

UniProtKB/Swiss-Prot Entry Name

PARPT_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
Katoh M, Katoh M: Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. Int J Oncol. 2003 Aug;23(2):541-7. [PubMed:12851707 ]