| Identification |
|---|
| HMDB Protein ID
| HMDBP08828 |
| Secondary Accession Numbers
| |
| Name
| Three prime repair exonuclease 2 |
| Synonyms
|
- 3'-5' exonuclease TREX2
|
| Gene Name
| TREX2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in exonuclease activity |
| Specific Function
| Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| nucleic acid binding |
| nuclease activity |
| exonuclease activity |
|
| Cellular Location
|
- Nucleus (Probable)
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| TREX2 |
| Gene Sequence
|
>840 bp
ATGGGGCGGGCAGGAAGCCCTCTCCCAAGATCGAGTTGGCCGAGGATGGATGATTGTGGC
AGCAGAAGCCGTTGCAGCCCCACGTTGTGCTCTAGTTTGAGGACTTGCTATCCCCGTGGG
AACATCACCATGTCCGAGGCACCCCGGGCCGAGACCTTTGTCTTCCTGGACCTGGAAGCC
ACTGGGCTCCCCAGTGTGGAGCCCGAGATTGCCGAGCTGTCCCTCTTTGCTGTCCACCGC
TCCTCCCTGGAGAACCCGGAGCACGACGAGTCTGGTGCCCTAGTATTGCCCCGGGTCCTG
GACAAGCTCACGCTGTGCATGTGCCCGGAGCGCCCCTTCACTGCCAAGGCCAGCGAGATC
ACCGGCCTGAGCAGTGAGGGCCTGGCGCGATGCCGGAAGGCTGGCTTTGATGGCGCCGTG
GTGCGGACGCTGCAGGCCTTCCTGAGCCGCCAGGCAGGGCCCATCTGCCTTGTGGCCCAC
AATGGCTTTGATTATGATTTCCCCCTGCTGTGTGCCGAGCTGCGGCGCCTGGGTGCCCGC
CTGCCCCGGGACACTGTCTGCCTGGACACGCTGCCGGCCCTGCGGGGCCTGGACCGCGCC
CACAGCCACGGCACCCGGGCCCGGGGCCGCCAGGGTTACAGCCTCGGCAGCCTCTTCCAC
CGCTACTTCCGGGCAGAGCCAAGCGCAGCCCACTCAGCCGAGGGCGACGTGCACACCCTG
CTCCTGATCTTCCTGCACCGCGCCGCAGAGCTGCTCGCCTGGGCCGATGAGCAGGCCCGT
GGGTGGGCCCACATCGAGCCCATGTACTTGCCGCCTGATGACCCCAGCCTGGAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 279 |
| Molecular Weight
| 30620.4 |
| Theoretical pI
| 6.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Three prime repair exonuclease 2
MGRAGSPLPRSSWPRMDDCGSRSRCSPTLCSSLRTCYPRGNITMSEAPRAETFVFLDLEA
TGLPSVEPEIAELSLFAVHRSSLENPEHDESGALVLPRVLDKLTLCMCPERPFTAKASEI
TGLSSEGLARCRKAGFDGAVVRTLQAFLSRQAGPICLVAHNGFDYDFPLLCAELRRLGAR
LPRDTVCLDTLPALRGLDRAHSHGTRARGRQGYSLGSLFHRYFRAEPSAAHSAEGDVHTL
LLIFLHRAAELLAWADEQARGWAHIEPMYLPPDDPSLEA
|
| External Links |
|---|
| GenBank ID Protein
| 12751319 |
| UniProtKB/Swiss-Prot ID
| Q9BQ50 |
| UniProtKB/Swiss-Prot Entry Name
| TREX2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF319571 |
| GeneCard ID
| TREX2 |
| GenAtlas ID
| TREX2 |
| HGNC ID
| HGNC:12270 |
| References |
|---|
| General References
| - Mazur DJ, Perrino FW: Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60. [PubMed:10391904 ]
- Mazur DJ, Perrino FW: Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. J Biol Chem. 2001 May 4;276(18):14718-27. Epub 2001 Jan 29. [PubMed:11278605 ]
- Mazur DJ, Perrino FW: Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. J Biol Chem. 2001 May 18;276(20):17022-9. Epub 2001 Mar 6. [PubMed:11279105 ]
- Perrino FW, Harvey S, McMillin S, Hollis T: The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis. J Biol Chem. 2005 Apr 15;280(15):15212-8. Epub 2005 Jan 19. [PubMed:15661738 ]
|
