Hmdb loader
Identification
HMDB Protein ID HMDBP08694
Secondary Accession Numbers
  • 14415
Name Sideroflexin-4
Synonyms
  1. Breast cancer resistance marker 1
Gene Name SFXN4
Protein Type Unknown
Biological Properties
General Function Involved in cation transmembrane transporter activity
Specific Function Potential iron transporter
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
Process
establishment of localization
transport
ion transport
cation transport
transmembrane transport
Cellular Location
  1. Mitochondrion membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 10q26.11
SNPs SFXN4
Gene Sequence
>1014 bp
ATGTCCCTGGAACAGGAGGAGGAAACGCAACCTGGGCGGCTCCTAGGACGCAGAGACGCC
GTCCCCGCCTTCATTGAGCCCAACGTGCGCTTCTGGATCACCGAGCGCCAATCCTTTATT
CGACGATTTCTTCAATGGACAGAATTATTAGATCCTACAAATGTGTTCATTTCAGTTGAA
AGTATAGAAAACTCGAGGCAACTATTGTGCACAAATGAAGATGTTTCCAGCCCTGCCTCG
GCGGACCAAAGGATACAAGAAGCTTGGAAGCGGAGTCTTGCAACAGTGCATCCCGACAGC
AGCAACCTGATCCCCAAGCTTTTTCGACCTGCAGCGTTCCTGCCTTTCATGGCGCCCACG
GTATTTTTGTCAATGACGCCACTGAAAGGGATCAAGTCCGTGATTTTACCTCAGGTTTTC
CTCTGTGCCTACATGGCAGCGTTCAACAGCATCAATGGAAACAGAAGTTACACTTGTAAG
CCACTAGAAAGATCATTACTAATGGCGGGAGCCGTTGCTTCTTCAACTTTCTTAGGAGTA
ATCCCTCAGTTTGTCCAGATGAAGTATGGCCTGACTGGCCCTTGGATTAAAAGACTCTTA
CCTGTGATCTTCCTCGTGCAAGCCAGTGGAATGAATGTCTACATGTCCCGAAGTCTTGAA
TCCATTAAGGGGATTGCGGTCATGGACAAGGAAGGCAATGTCCTGGGTCATTCCAGAATT
GCTGGGACAAAGGCTGTTAGAGAAACGCTAGCATCCAGAATAGTGCTGTTTGGGACCTCA
GCTCTGATTCCTGAAGTCTTCACCTACTTTTTTAAAAGGACCCAGTATTTCAGGAAAAAC
CCAGGGTCATTGTGGATTTTGAAACTGTCTTGTACTGTCCTGGCAATGGGACTGATGGTG
CCATTTTCTTTTAGTATATTTCCACAGATTGGACAGATACAGTACTGTAGTCTTGAAGAG
AAAATTCAGTCTCCAACAGAAGAAACAGAAATCTTTTATCACAGAGGGGTGTAG
Protein Properties
Number of Residues 337
Molecular Weight 37998.0
Theoretical pI 9.55
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 111-131
  • 133-153
  • 165-185
  • 251-271
  • 293-313
Protein Sequence
>Sideroflexin-4
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQSFIRRFLQWTELLDPTNVFISVE
SIENSRQLLCTNEDVSSPASADQRIQEAWKRSLATVHPDSSNLIPKLFRPAAFLPFMAPT
VFLSMTPLKGIKSVILPQVFLCAYMAAFNSINGNRSYTCKPLERSLLMAGAVASSTFLGV
IPQFVQMKYGLTGPWIKRLLPVIFLVQASGMNVYMSRSLESIKGIAVMDKEGNVLGHSRI
AGTKAVRETLASRIVLFGTSALIPEVFTYFFKRTQYFRKNPGSLWILKLSCTVLAMGLMV
PFSFSIFPQIGQIQYCSLEEKIQSPTEETEIFYHRGV
GenBank ID Protein 47458811
UniProtKB/Swiss-Prot ID Q6P4A7
UniProtKB/Swiss-Prot Entry Name SFXN4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_213649.1
GeneCard ID SFXN4
GenAtlas ID SFXN4
HGNC ID HGNC:16088
References
General References
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  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  4. Zheng H, Ji C, Zou X, Wu M, Jin Z, Yin G, Li J, Feng C, Cheng H, Gu S, Xie Y, Mao Y: Molecular cloning and characterization of a novel human putative transmembrane protein homologous to mouse sideroflexin associated with sideroblastic anemia. DNA Seq. 2003 Oct;14(5):369-73. [PubMed:14756423 ]