Hmdb loader
Identification
HMDB Protein ID HMDBP08583
Secondary Accession Numbers
  • 14298
Name Protein sprouty homolog 4
Synonyms
  1. Spry-4
Gene Name SPRY4
Protein Type Unknown
Biological Properties
General Function Involved in multicellular organismal development
Specific Function Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane
Process
biological regulation
regulation of biological process
regulation of cellular process
multicellular organismal process
regulation of cell communication
regulation of signal transduction
multicellular organismal development
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Cytoplasmic side (Potential)
  4. Cell projection
  5. ruffle membrane
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31.3
SNPs SPRY4
Gene Sequence
>900 bp
ATGGAGCCCCCGATCCCACAGAGCGCCCCCTTGACTCCCAACTCAGTCATGGTCCAGCCC
CTTCTTGACAGCCGGATGTCCCACAGCCGGCTCCAGCACCCACTCACCATCCTACCCATT
GACCAGGTGAAGACCAGCCATGTGGAGAATGACTACATAGACAACCCTAGCCTGGCCCTG
ACCACCGGCCCAAAGCGGACCCGGGGCGGGGCCCCAGAGCTGGCCCCGACGCCCGCCCGC
TGTGACCAGGATGTCACCCACCATTGGATCTCCTTCAGCGGGCGCCCCAGCTCTGTGAGC
AGCAGCAGCAGCACATCCTCTGACCAACGGCTCTTAGACCACATGGCACCACCACCCGTG
GCTGACCAGGCCTCACCAAGGGCTGTGCGCATCCAGCCCAAGGTGGTCCACTGCCAGCCG
CTGGACCTCAAGGGCCCGGCGGTCCCACCCGAGCTGGACAAGCACTTCTTGCTGTGCGAG
GCCTGTGGGAAGTGTAAATGCAAGGAGTGTGCATCCCCCCGGACGTTGCCTTCCTGCTGG
GTCTGCAACCAGGAGTGCCTGTGCTCAGCCCAGACTCTGGTCAACTATGGCACGTGCATG
TGTTTGGTGCAGGGCATCTTCTACCACTGCACGAATGAGGACGATGAGGGCTCCTGCGCT
GACCACCCCTGCTCCTGCTCCCGCTCCAACTGCTGCGCCCGCTGGTCCTTCATGGGTGCT
CTCTCCGTGGTGCTGCCCTGCCTGCTCTGCTACCTGCCTGCCACCGGCTGCGTGAAGCTG
GCCCAGCGTGGCTACGACCGTCTGCGCCGCCCTGGTTGCCGCTGCAAGCACACGAACAGC
GTCATCTGCAAAGCAGCCAGCGGGGATGCCAAGACCAGCAGGCCCGACAAGCCTTTCTGA
Protein Properties
Number of Residues 299
Molecular Weight 32541.0
Theoretical pI 7.92
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Protein sprouty homolog 4
MEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNPSLAL
TTGPKRTRGGAPELAPTPARCDQDVTHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPV
ADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFLLCEACGKCKCKECASPRTLPSCW
VCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSNCCARWSFMGA
LSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDAKTSRPDKPF
GenBank ID Protein 188595697
UniProtKB/Swiss-Prot ID Q9C004
UniProtKB/Swiss-Prot Entry Name SPY4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001127496.1
GeneCard ID SPRY4
GenAtlas ID SPRY4
HGNC ID HGNC:15533
References
General References
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