Human Metabolome Database: Showing Protein Rhophilin-1 (HMDBP08553)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08553

Secondary Accession Numbers

14267

Name

Rhophilin-1

Synonyms

GTP-Rho-binding protein 1

Gene Name

RHPN1

Protein Type

Unknown

Biological Properties

General Function

Involved in signal transduction

Specific Function

Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
intracellular
Function
binding
protein binding
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction

Cellular Location

Not Available

Gene Properties

Chromosome Location

Chromosome:8

Locus

8q24.3

SNPs

RHPN1

Gene Sequence

>2088 bp
ATGATCCTGGAGGAGAGGCCGGACGGCGCGGGCGCCGGCGAGGAGAGCCCGCGGCTGCAG
GGCTGTGACTCCCTGACGCAGATCCAGTGCGGCCAGCTGCAGAGCCGCAGGGCCCAGATT
CACCAGCAGATTGACAAGGAGCTGCAGATGCGGACGGGCGCTGAGAACCTCTACAGAGCC
ACCAGCAACAACCGGGTGAGAGAGACGGTCGCCCTGGAGCTGAGCTACGTCAACTCCAAC
CTGCAGCTGCTGAAGGAGGAGCTGGAGGAGCTCAGCGGTGGCGTGGACCCTGGCCGGCAT
GGGAGCGAAGCTGTCACTGTCCCCATGATCCCCCTGGGCCTGAAGGAGACCAAGGAGCTG
GACTGGTCTACACCGCTGAAGGAGCTGATCTCAGTGCACTTTGGAGAGGACGGCGCCTCC
TACGAGGCAGAAATCAGGGAGCTGGAGGCCCTGCGGCAGGCCATGCGGACCCCCAGCCGG
AATGAGTCGGGCCTGGAGCTGCTCACAGCCTATTACAACCAGCTGTGCTTCCTGGATGCG
CGCTTCCTCACCCCTGCCAGGAGCCTCGGGCTCTTCTTCCACTGGTACGACTCGCTTACT
GGGGTCCCGGCCCAGCAGCGTGCCCTGGCCTTCGAGAAGGGCAGCGTTCTCTTCAACATC
GGTGCCCTCCACACGCAGATTGGGGCGCGCCAGGACCGCTCCTGCACCGAGGGTGCCCGC
CGCGCTATGGAGGCCTTCCAGAGGGCCGCTGGGGCCTTCAGCCTCCTGAGGGAGAACTTC
TCCCATGCGCCGAGCCCAGACATGAGCGCTGCGTCCCTCTGCGCACTGGAGCAGCTCATG
ATGGCCCAGGCCCAGGAATGTGTGTTTGAGGGCCTCTCACCACCTGCCTCCATGGCCCCC
CAAGACTGCCTGGCCCAGCTGCGCCTGGCGCAGGAGGCCGCCCAGGTGGCAGCCGAGTAC
AGGCTAGTGCACCGGACCATGGCCCAGCCACCCGTCCACGACTACGTGCCTGTCTCCTGG
ACTGCCCTGGTGCATGTCAAGGCCGAGTACTTCCGCTCCCTGGCCCACTACCACGTAGCC
ATGGCCCTCTGCGACGGCTCCCGTGAGTGCCCACCACACTTGCCCATGGTACTGCCAAGG
CCCCCCCGCGCAGGCTCACAGCCTCTCTGTCCCCCAGCAGCGACCGAGGGAGAGCTCCCC
ACGCACGAGCAGGTCTTCCTGCAGCCCCCCACCTCCTCTAAGCCCCGAGGCCCTGTGCTG
CCGCAGGAGCTGGAGGAGCGCAGGCAGCTTGGCAAGGCACACCTGAAGCGTGCCATCCTG
GGGCAGGAGGAGGCGCTGCGGCTGCACGCCCTGTGCCGCGTCCTGCGCGAGGTGGACCTG
CTTCGGGCTGTGATCTCCCAGACGCTGCAGCGCTCACTGGCCAAGTATGCGGAGCTCGAC
CGTGAGGATGACTTCTGTGAGGCTGCCGAGGCCCCGGACATCCAGCCTAAGACCCACCAG
AAGCCAGAGGCCAGGATGCCACGCCTGTCCCAGGGGAAGGGGCCTGACATCTTCCATCGG
CTGGGGCCCCTGTCTGTGTTCTCAGCCAAGAACCGGTGGCGGCTGGTGGGGCCCGTCCAC
CTGACCCGAGGAGAGGGCGGCTTTGGCCTCACGCTTCGGGGAGACTCGCCTGTCCTCATC
GCTGCCGTCATTCCAGGGAGCCAGGCCGCGGCGGCTGGCCTGAAGGAGGGCGACTACATT
GTGTCAGTGAATGGGCAGCCATGCAGGTGGTGGAGACACGCGGAGGTGGTGACGGAGCTG
AAGGCTGCGGGAGAGGCGGGCGCCAGCCTGCAGGTGGTGTCGCTGCTGCCCAGCTCTAGA
CTGCCCAGCTTGGGGGACCGCCGGCCCGTCCTGCTGGGCCCCAGGGGGCTTCTAAGGAGC
CAGAGGGAGCATGGTTGCAAGACCCCGGCATCCACGTGGGCCAGTCCCCGGCCCCTCCTC
AACTGGAGCCGAAAGGCCCAGCAGGGCAAGACTGGAGGCTGCCCCCAGCCCTGTGCCCCA
GTGAAGCCAGCTCCGCCCTCATCCTTGAAGCACCCAGGGTGGCCGTGA

Protein Properties

Number of Residues

695

Molecular Weight

76291.4

Theoretical pI

7.82

Pfam Domain Function

PDZ (PF00595 )
HR1 (PF02185 )
BRO1 (PF03097 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Rhophilin-1
MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA
TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL
DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA
RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR
RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP
QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA
MALCDGSRECPPHLPMVLPRPPRAGSQPLCPPAATEGELPTHEQVFLQPPTSSKPRGPVL
PQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELD
REDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVH
LTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTEL
KAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLL
NWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP

External Links

GenBank ID Protein

19697913

UniProtKB/Swiss-Prot ID

Q8TCX5

UniProtKB/Swiss-Prot Entry Name

RHPN1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Nagase T, Kikuno R, Ohara O: Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. DNA Res. 2001 Aug 31;8(4):179-87. [PubMed:11572484 ]