Hmdb loader
Identification
HMDB Protein ID HMDBP08529
Secondary Accession Numbers
  • 14241
Name ELKS/Rab6-interacting/CAST family member 1
Synonyms
  1. ERC-1
  2. Rab6-interacting protein 2
Gene Name ERC1
Protein Type Unknown
Biological Properties
General Function Involved in protein transport
Specific Function Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport
Pathways Not Available
Reactions Not Available
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Process
establishment of localization
transport
protein transport
Cellular Location
  1. Cytoplasm
  2. Golgi apparatus membrane
  3. Peripheral membrane protein
  4. Peripheral membrane protein
  5. Membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 12p13.3
SNPs ERC1
Gene Sequence
>3351 bp
ATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGT
TCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTACGGGAGGG
AGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAA
TCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTG
GGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCTGCCTTAC
GGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGT
GACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCT
CACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCTGAAGGAA
GTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGT
TCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTG
AGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGTACAGGAG
GAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGG
GACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCA
GAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGCCAAAGAG
CTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAG
ACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGA
CTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGAGGCAGAG
ATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTG
AGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTG
CAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCTTCGAGAC
CTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAA
GAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTA
GAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAAAAAGAAA
GCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACA
GAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAA
CAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTG
CAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAA
AAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACAT
GACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATT
GAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGG
GTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAG
GCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAG
CGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAA
GTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAG
CATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAG
ATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCA
CATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTG
GAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGA
CTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCT
GAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAA
CAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAAT
CTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAA
GAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTA
GCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGGAGGAGTTACTGATGGCC
ATGGAGAAGGTAAAGCAGGAACTAGAATCCATGAAAGCAAAGCTGTCCTCCACCCAGCAG
TCTCTGGCAGAAAAGGAAACTCACTTGACTAATCTTCGGGCAGAGAGAAGGAAACACTTA
GAGGAAGTTCTGGAGATGAAGCAAGAAGCTCTTCTGGCTGCCATTAGTGAAAAAGACGCC
AATATAGCTCTCTTGGAGCTTTCGTCCTCTAAGAAGAAGACCCAAGAGGAAGTGGCTGCC
CTGAAGCGGGAGAAGGATCGTCTGGTACAGCAGCTTAAGCAGCAGACGCAAAATCGAATG
AAGCTAATGGCCGACAACTACGAGGATGACCACTTCAAATCCTCCCATTCCAATCAAACA
AATCACAAGCCCTCCCCAGACCAGATCATCCAGCCCCTCTTAGAACTTGACCAAAATAGA
AGTAAATTAAAGTTGTACATTGGACACCTGACAACCCTCTGCCATGACCGAGACCCCCTG
ATCCTCCGTGGACTCACTCCACCAGCTTCCTATAACTTGGACGATGACCAGGCGGCTTGG
GAGAATGAGCTGCAGAAGATGACCCGGGGGCAGCTTCAGGATGAGTTAGAGAAAGGTGAA
CGGGACAATGCAGAACTGCAGGAGTTTGCCAACGCCATTCTTCAGCAGATAGCAGACCAT
TGTCCCGACATCCTAGAGCAAGTGGTCAACGCCCTGGAAGAGTCCTCTTGA
Protein Properties
Number of Residues 1116
Molecular Weight 128085.4
Theoretical pI 5.8
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>ELKS/Rab6-interacting/CAST family member 1
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ
SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS
DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR
DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ
TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE
EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT
ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER
VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK
VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA
ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE
ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA
LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR
SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE
RDNAELQEFANAILQQIADHCPDILEQVVNALEESS
GenBank ID Protein 38045898
UniProtKB/Swiss-Prot ID Q8IUD2
UniProtKB/Swiss-Prot Entry Name RB6I2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_178040.2
GeneCard ID ERC1
GenAtlas ID ERC1
HGNC ID HGNC:17072
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
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  6. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [PubMed:12168954 ]
  7. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Jun 30;6(3):197-205. [PubMed:10470851 ]
  8. Nakata T, Kitamura Y, Shimizu K, Tanaka S, Fujimori M, Yokoyama S, Ito K, Emi M: Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma. Genes Chromosomes Cancer. 1999 Jun;25(2):97-103. [PubMed:10337992 ]
  9. Nakata T, Yokota T, Emi M, Minami S: Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. Genes Chromosomes Cancer. 2002 Sep;35(1):30-7. [PubMed:12203787 ]
  10. Ducut Sigala JL, Bottero V, Young DB, Shevchenko A, Mercurio F, Verma IM: Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science. 2004 Jun 25;304(5679):1963-7. [PubMed:15218148 ]
  11. Ko J, Na M, Kim S, Lee JR, Kim E: Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. J Biol Chem. 2003 Oct 24;278(43):42377-85. Epub 2003 Aug 15. [PubMed:12923177 ]