Human Metabolome Database: Showing Protein Protein-methionine sulfoxide oxidase MICAL3 (HMDBP08276)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 metabolites

Identification

HMDB Protein ID

HMDBP08276

Secondary Accession Numbers

13988

Name

Protein-methionine sulfoxide oxidase MICAL3

Synonyms

Molecule interacting with CasL protein 3
MICAL-3

Gene Name

MICAL3

Protein Type

Unknown

Biological Properties

General Function

Involved in monooxygenase activity

Specific Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.

Pathways

Not Available

Reactions

[protein]-methionine + NADPH + Oxygen → [protein]-methionine-sulfoxide + NADP + Water

details

GO Classification

Biological Process
exocytosis
actin filament depolymerization
Cellular Component
cytoskeleton
cytoplasm
Function
monooxygenase activity
ion binding
oxidoreductase activity
zinc ion binding
transition metal ion binding
catalytic activity
binding
metal ion binding
cation binding
Molecular Function
metal ion binding
zinc ion binding
FAD binding
actin binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
Process
oxidation reduction
metabolic process

Cellular Location

Cytoplasm
Cytoplasm
cytoskeleton

Gene Properties

Chromosome Location

Locus

22q11.21

SNPs

MICAL3

Gene Sequence

>6009 bp
ATGGAGGAGAGGAAGCATGAGACCATGAACCCAGCTCATGTCCTCTTTGACCGGTTTGTC
CAGGCCACCACCTGCAAGGGAACCCTCAAGGCTTTCCAGGAGCTCTGTGACCACCTGGAA
CTAAAGCCAAAGGACTACCGCTCCTTCTATCACAAGCTCAAGTCCAAGCTTAACTACTGG
AAAGCCAAAGCCCTCTGGGCAAAATTGGACAAACGGGGCAGTCACAAAGACTACAAAAAG
GGAAAAGCGTGCACTAACACCAAGTGTCTCATCATTGGGGCTGGCCCCTGTGGTCTCCGT
ACAGCCATCGACTTATCCTTACTGGGGGCCAAGGTGGTTGTTATTGAGAAACGAGATGCC
TTCTCCCGCAACAACGTCTTGCATCTCTGGCCATTCACCATACATGATCTACGAGGTCTG
GGTGCCAAGAAGTTCTATGGCAAGTTCTGTGCTGGAGCCATCGACCATATCAGTATCCGT
CAGCTCCAACTAATACTTTTGAAAGTAGCCTTGATCCTAGGCATTGAAATCCACGTCAAT
GTGGAATTCCAAGGACTTATACAGCCTCCTGAGGACCAAGAGAATGAACGGATAGGCTGG
CGGGCACTGGTGCACCCCAAGACTCATCCTGTGTCAGAGTATGAATTTGAAGTGATCATC
GGTGGGGATGGTCGGAGGAACACCTTGGAAGGGTTTCGTCGGAAAGAATTCCGTGGCAAA
CTGGCCATCGCCATCACGGCAAATTTTATCAACCGAAATACAACAGCAGAAGCTAAAGTG
GAAGAGATCAGTGGTGTGGCTTTTATATTCAACCAAAAATTTTTCCAGGAACTGAGGGAA
GCCACAGGTATTGACTTGGAGAACATCGTTTACTACAAAGATGACACACACTATTTCGTT
ATGACAGCCAAAAAGCAGAGTTTGCTGGACAAAGGAGTGATACTACATGACTACGCCGAC
ACAGAGCTCCTGCTTTCCCGAGAAAACGTGGACCAGGAGGCTCTGCTCAGCTATGCCAGG
GAGGCGGCAGACTTCTCTACCCAGCAGCAGCTGCCGTCTCTGGATTTTGCCATCAATCAC
TATGGGCAGCCCGATGTGGCCATGTTTGACTTCACTTGTATGTATGCCTCCGAGAACGCC
GCCTTGGTGCGGGAGCAGAACGGACACCAGTTACTAGTGGCTCTGGTCGGGGACAGCCTC
CTAGAGCCTTTCTGGCCAATGGGAACAGGAATAGCCCGGGGCTTTCTAGCTGCTATGGAC
TCTGCCTGGATGGTCCGAAGTTGGTCTCTAGGAACGAGCCCTTTGGAAGTGCTGGCAGAG
AGGGAAAGTATTTACAGGTTGCTGCCTCAGACCACCCCTGAGAATGTGAGTAAGAACTTC
AGCCAGTACAGTATCGACCCTGTCACTCGGTATCCCAATATCAACGTCAACTTCCTCCGG
CCAAGCCAGGTGCGCCATTTATATGATACTGGCGAAACAAAAGATATTCACCTGGAAATG
GAGAGCCTGGTGAATTCCCGAACCACCCCCAAATTGACTCGCAATGAGTCTGTAGCTCGT
TCAAGCAAACTGCTGGGTTGGTGCCAGAGGCAGACAGATGGCTATGCAGGGGTAAACGTG
ACAGATCTCACCATGTCCTGGAAAAGTGGCTTGGCCCTTTGTGCAATTATCCATAGATAC
CGCCCTGACCTGATAGATTTTGATTCTTTGGATGAGCAAAATGTGGAGAAGAATAACCAA
CTGGCCTTTGACATTGCTGAGAAGGAATTGGGCATTTCTCCCATCATGACAGGCAAAGAA
ATGGCCTCCGTGGGGGAGCCTGATAAGCTGTCCATGGTGATGTACCTGACTCAGTTCTAC
GAGATGTTTAAGGACTCCCTCCCCTCTAGCGACACCTTGGACCTAAATGCCGAGGAGAAA
GCAGTCCTGATAGCCAGCACCAGATCCCCTATCTCCTTCCTAAGCAAACTTGGCCAGACC
ATCTCTCGGAAGCGTTCTCCCAAGGATAAAAAGGAAAAGGACTTGGATGGTGCTGGGAAG
AGGAGAAAGACCAGTCAATCAGAGGAGGAGGAAGCTCCTCGGGGCCACAGAGGAGAAAGA
CCGACCCTGGTGAGCACTCTGACAGACAGGAGGATGGACGTTGCCGTTGGGAACCAGAAC
AAAGTGAAGTACATGGCGACCCAGCTGCTGGCCAAATTTGAAGAGAATGCGCCCGCACAG
TCCATCGGCATACGGAGACAGGGCTCCATGAAGAAGGAGTTCCCGCAGAACCTGGGAGGC
AGCGACACATGCTACTTCTGCCAGAAGCGGGTCTACGTGATGGAGAGGCTGAGTGCCGAG
GGCAAGTTCTTCCACCGGAGCTGCTTCAAGTGCGAGTACTGCGCCACCACCCTGCGCCTC
TCGGCCTACGCCTACGACATCGAGGATGGTAAATTCTACTGTAAGCCACACTACTGCTAT
CGACTCTCTGGCTACGCACAAAGGAAGAGACCGGCAGTGGCTCCCCTGTCTGGAAAGGAG
GCCAAAGGACCCCTGCAGGATGGCGCCACCACAGATGCAAACGGACGGGCCAACGCCGTG
GCCAGCTCCACTGAGAGAACCCCAGGTTCAGGCGTGAACGGCCTGGAGGAGCCCAGCATC
GCCAAGCGACTGAGGGGCACCCCAGAGCGGATCGAGCTGGAGAACTACCGCCTGTCCCTG
AGGCAGGCTGAGGCACTGCAGGAGGTACCGGAGGAGACTCAGGCCGAGCACAACCTGAGC
AGCGTGCTGGACACGGGCGCCGAGGAGGACGTCGCCAGCAGTAGTTCCGAGTCTGAGATG
GAGGAGGAGGGAGAGGAGGAGGAGGAGGAGCCTCGCCTGCCCCCATCTGACCTGGGTGGT
GTTCCGTGGAAGGAGGCCGTGCGGATCCATGCCCTTCTGAAAGGGAAAAGTGAAGAGGAG
CTAGAGGCCTCAAAGAGCTTTGGGCCTGGGAATGAAGAGGAGGAGGAGGAGGAGGAAGAA
TATGAAGAGGAGGAGGAGGAGGACTATGACGAGGAGGAGGAAGAGTCCAGTGAAGCCGGG
AACCAGAGGCTCCAGCAGGTCATGCACGCGGCGGATCCTCTGGAGATCCAGGCTGACGTG
CACTGGACTCATATCCGTGAGAGAGAGGAGGAAGAGAGGATGGCGCCGGCCTCTGAGTCC
TCTGCTTCCGGAGCCCCATTGGATGAGAATGACCTAGAGGAAGATGTGGACTCAGAACCA
GCCGAGATAGAAGGGGAGGCAGCAGAGGATGGGGACCCAGGGGACACTGGTGCTGAGCTG
GATGATGATCAGCACTGGTCTGACAGCCCGTCGGATGCTGACAGAGAGCTGCGTTTGCCG
TGCCCAGCTGAGGGGGAAGCAGAGCTGGAGCTGAGGGTGTCGGAAGATGAGGAGAAGCTG
CCCGCCTCACCGAAGCACCAAGAGAGAGGTCCCTCCCAAGCCACCAGCCCCATCCGGTCT
CCCCAGGAATCAGCTCTTCTGTTCATTCCAGTCCACAGCCCCTCAACAGAGGGGCCCCAA
CTCCCACCTGTCCCTGCCGCCACCCAGGAGAAATCACCTGAGGAGCGCCTTTTCCCTGAG
CCTTTGCTCCCCAAAGAGAAGCCCAAAGCTGATGCCCCCTCGGATCTGAAAGCTGTGCAC
TCTCCCATCCGATCACAGCCAGTGACCCTGCCAGAAGCTAGGACTCCTGTCTCACCAGGG
AGCCCGCAGCCCCAGCCACCCGTGGCGGCCTCCACGCCCCCACCCAGCCCACTCCCCATC
TGCTCCCAGCCCCAGCCTTCCACCGAGGCCACTGTCCCATCCCCTACCCAGTCCCCCATA
CGCTTCCAGCCTGCCCCGGCCAAAACATCCACCCCACTGGCCCCTCTCCCTGTCCAAAGC
CAAAGTGACACCAAGGACAGACTGGGCAGCCCCCTTGCTGTGGATGAGGCCCTCAGACGG
AGCGACCTGGTGGAGGAGTTCTGGATGAAGAGTGCGGAGATCCGCCGCAGCCTCGGGCTC
ACACCTGTGGACCGCAGCAAGGGGCCCGAGCCCAGCTTCCCCACGCCTGCCTTCAGGCCA
GTGTCCCTCAAATCCTATTCCGTTGAAAAGTCCCCCCAGGATGAGGGACTCCACCTTCTC
AAGCCTCTGTCCATCCCCAAAAGGCTGGGCCTGCCAAAGCCGGAAGGCGAGCCGTTGTCC
CTGCCAACCCCCCGGTCCCCGTCCGACAGAGAGCTACGCAGCGCCCAGGAGGAGCGCAGG
GAGCTGTCCAGCAGCTCTGGCCTGGGCCTGCACGGGAGCTCCTCCAACATGAAGACACTG
GGCAGCCAGAGCTTCAACACCTCGGACTCCGCCATGCTCACGCCCCCCTCCAGCCCGCCC
CCACCGCCACCCCCGGGCGAGGAGCCCGCCACCTTGCGGAGGAAGCTCAGGGAGGCCGAG
CCCAATGCCTCGGTGGTCCCGCCGCCCTTGCCCGCCACCTGGATGCGGCCCCCCCGGGAG
CCTGCTCAGCCCCCCAGAGAGGAGGTGCGGAAGTCGTTTGTGGAGAGCGTGGAGGAGATT
CCCTTTGCTGATGATGTGGAGGACACCTATGACGACAAGACTGAGGACTCAAGCCTGCAG
GAGAAATTCTTCACGCCCCCGTCCTGCTGGCCGCGCCCCGAGAAGCCTCGCCACCCGCCC
CTGGCCAAGGAGAACGGGAGGCTGCCTGCTCTGGAGGGGACGCTGCAGCCACAGAAGAGG
GGGCTGCCCTTGGTGTCCGCGGAAGCCAAGGAGTTGGCCGAGGAGCGCATGCGAGCCAGG
GAGAAGTCCGTGAAGAGCCAGGCGCTGCGGGACGCCATGGCCAGGCAGCTGAGCAGGATG
CAGCAGATGGAGCTGGCCTCAGGCGCCCCCAGGCCCCGCAAGGCGTCCTCAGCACCCTCC
CAGGGCAAGGAGCGCCGGCCTGACTCCCCCACACGCCCCACTCTCAGGGGCTCCGAGGAG
CCCACCCTGAAGCATGAAGCCACCAGCGAGGAGGTCCTCTCCCCGCCGTCGGACTCAGGG
GGCCCAGATGGCTCTTTCACTTCATCCGAGGGCTCCAGTGGGAAGAGCAAGAAGAGGTCG
TCACTCTTCTCCCCCCGCAGAAACAAGAAGGAGAAGAAGTCCAAAGGCGAGGGCCGGCCC
CCGGAGAAGCCCAGCTCCAACCTCCTAGAAGAAGCCGCCGCCAAACCCAAGTCCCTGTGG
AAGTCCGTCTTCTCCGGGTACAAGAAGGACAAGAAGAAGAAGGCCGACGACAAGTCCTGC
CCCAGCACCCCCTCCAGCGGGGCCACGGTGGACTCTGGAAAGCACAGGGTGCTTCCCGTC
GTAAGGGCAGAGCTGCAGCTCCGGCGCCAGCTGAGCTTCTCCGAGGACTCAGACCTCTCC
AGCGACGATGTCCTTGAGAAGTCCTCACAGAAGTCCCGGCGAGAGCCAAGAACCTACACG
GAGGAGGAACTGAATGCCAAGCTGACCCGGCGTGTGCAAAAGGCAGCTCGGAGACAGGCC
AAGCAGGAGGAGCTTAAGCGGCTGCATCGAGCCCAGATCATCCAGCGGCAGCTGCAGCAG
GTGGAGGAGAGGCAGCGGCGGCTGGAGGAAAGGGGCGTGGCTGTGGAGAAGGCGCTCCGG
GGCGAAGCAGGCATGGGCAAGAAGGACGACCCCAAGCTGATGCAGGAGTGGTTCAAGCTA
GTGCAGGAGAAGAACGCCATGGTGCGCTACGAGTCGGAGCTGATGATCTTTGCCCGGGAG
CTGGAGCTGGAAGACCGGCAGAGTCGACTGCAGCAGGAGCTCCGGGAACGCATGGCAGTG
GAAGATCACCTTAAGACTGAGGAGGAGCTGTCAGAAGAGAAGCAGATTCTCAATGAGATG
CTGGAGGTGGTGGAGCAGAGAGACTCACTGGTGGCGCTGCTGGAGGAGCAGCGGCTCCGG
GAGAGAGAGGAGGACAAGGACCTGGAGGCTGCCATGCTGTCCAAGGGCTTCAGCCTTAAC
TGGTCCTGA

Protein Properties

Number of Residues

2002

Molecular Weight

109046.185

Theoretical pI

7.85

Pfam Domain Function

LIM (PF00412 )
FAD_binding_3 (PF01494 )
CH (PF00307 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Protein MICAL-3
MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW
KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA
FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN
VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK
LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV
MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH
YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD
SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR
PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV
TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE
MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT
ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN
KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE
GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE
AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL
RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG
VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG
NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP
AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL
PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE
PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI
CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR
SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL
KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL
GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE
PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP
LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM
QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG
GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW
KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS
SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ
VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE
LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR
EREEDKDLEAAMLSKGFSLNWS

External Links

GenBank ID Protein

209862789

UniProtKB/Swiss-Prot ID

Q7RTP6

UniProtKB/Swiss-Prot Entry Name

MICA3_HUMAN

PDB IDs

2D88

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

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Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. [PubMed:15302935 ]
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Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. [PubMed:18220336 ]
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [PubMed:15461802 ]
Wang B, Malik R, Nigg EA, Korner R: Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. Anal Chem. 2008 Dec 15;80(24):9526-33. doi: 10.1021/ac801708p. [PubMed:19007248 ]
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [PubMed:10718198 ]
Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL: MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. Cell. 2002 Jun 28;109(7):887-900. [PubMed:12110185 ]
Fischer J, Weide T, Barnekow A: The MICAL proteins and rab1: a possible link to the cytoskeleton? Biochem Biophys Res Commun. 2005 Mar 11;328(2):415-23. [PubMed:15694364 ]