| Identification |
|---|
| HMDB Protein ID
| HMDBP08251 |
| Secondary Accession Numbers
| |
| Name
| Lysyl oxidase homolog 3 |
| Synonyms
|
- Lysyl oxidase-like protein 3
|
| Gene Name
| LOXL3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in copper ion binding |
| Specific Function
| Not Available |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| membrane |
| Function |
| signal transducer activity |
| copper ion binding |
| oxidoreductase activity, acting on the ch-nh2 group of donors, oxygen as acceptor |
| oxidoreductase activity, acting on the ch-nh2 group of donors |
| scavenger receptor activity |
| transmembrane receptor activity |
| receptor activity |
| oxidoreductase activity |
| ion binding |
| molecular transducer activity |
| transition metal ion binding |
| catalytic activity |
| binding |
| metal ion binding |
| cation binding |
| Process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Secreted
- extracellular space (Potential)
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p13 |
| SNPs
| LOXL3 |
| Gene Sequence
|
>2262 bp
ATGCGACCTGTCAGTGTCTGGCAGTGGAGCCCCTGGGGGCTGCTGCTGTGCCTGCTGTGC
AGTTCGTGCTTGGGGTCTCCGTCCCCTTCCACGGGCCCTGAGAAGAAGGCCGGGAGCCAG
GGGCTTCGGTTCCGGCTGGCTGGCTTCCCCAGGAAGCCCTACGAGGGCCGCGTGGAGATA
CAGCGAGCTGGTGAATGGGGCACCATCTGCGATGATGACTTCACGCTGCAGGCTGCCCAC
ATCCTCTGCCGGGAGCTGGGCTTCACAGAGGCCACAGGCTGGACCCACAGTGCCAAATAT
GGCCCTGGAACAGGCCGCATCTGGCTGGACAACTTGAGCTGCAGTGGGACCGAGCAGAGT
GTGACTGAATGTGCCTCCCGGGGCTGGGGGAACAGTGACTGTACGCACGATGAGGATGCT
GGGGTCATCTGCAAAGACCAGCGCCTCCCTGGCTTCTCGGACTCCAATGTCATTGAGGTA
GAGCATCACCTGCAAGTGGAGGAGGTGCGAATTCGACCCGCCGTTGGGTGGGGCAGACGA
CCCCTGCCCGTGACGGAGGGGCTGGTGGAAGTCAGGCTTCCTGACGGCTGGTCGCAAGTG
TGCGACAAAGGCTGGAGCGCCCACAACAGCCACGTGGTCTGCGGGATGCTGGGCTTCCCC
AGCGAAAAGAGGGTCAACGCGGCCTTCTACAGGCTGCTAGCCCAACGGCAGCAACACTCC
TTTGGTCTGCATGGGGTGGCGTGCGTGGGCACGGAGGCCCACCTCTCCCTCTGTTCCCTG
GAGTTCTATCGTGCCAATGACACCGCCAGGTGCCCTGGGGGGGGCCCTGCAGTGGTGAGC
TGTGTGCCAGGCCCTGTCTACGCGGCATCCAGTGGCCAGAAGAAGCAACAACAGTCGAAG
CCTCAGGGGGAGGCCCGTGTCCGTCTAAAGGGCGGCGCCCACCCTGGAGAGGGCCGGGTA
GAAGTCCTGAAGGCCAGCACATGGGGCACAGTCTGTGACCGCAAGTGGGACCTGCATGCA
GCCAGCGTGGTGTGTCGGGAGCTGGGCTTCGGGAGTGCTCGAGAAGCTCTGAGTGGCGCT
CGCATGGGGCAGGGCATGGGTGCTATCCACCTGAGTGAAGTTCGCTGCTCTGGACAGGAG
CTCTCCCTCTGGAAGTGCCCCCACAAGAACATCACAGCTGAGGATTGTTCACATAGCCAG
GATGCCGGGGTCCGGTGCAACCTACCTTACACTGGGGCAGAGACCAGGATCCGACTCAGT
GGGGGCCGCAGCCAACATGAGGGGCGAGTCGAGGTGCAAATAGGGGGACCTGGGCCCCTT
CGCTGGGGCCTCATCTGTGGGGATGACTGGGGGACCCTGGAGGCCATGGTGGCCTGTAGG
CAACTGGGTCTGGGCTACGCCAACCACGGCCTGCAGGAGACCTGGTACTGGGACTCTGGG
AATATAACAGAGGTGGTGATGAGTGGAGTGCGCTGCACAGGGACTGAGCTGTCCCTGGAT
CAGTGTGCCCATCATGGCACCCACATCACCTGCAAGAGGACAGGGACCCGCTTCACTGCT
GGAGTCATCTGTTCTGAGACTGCATCAGATCTGTTGCTGCACTCAGCACTGGTGCAGGAG
ACCGCCTACATCGAAGACCGGCCCCTGCATATGTTGTACTGTGCTGCGGAAGAGAACTGC
CTGGCCAGCTCAGCCCGCTCAGCCAACTGGCCCTATGGTCACCGGCGTCTGCTCCGATTC
TCCTCCCAGATCCACAACCTGGGACGAGCTGACTTCAGGCCCAAGGCTGGGCGCCACTCC
TGGGTGTGGCACGAGTGCCATGGGCATTACCACAGCATGGACATCTTCACTCACTATGAT
ATCCTCACCCCAAATGGCACCAAGGTGGCTGAGGGCCACAAAGCTAGTTTCTGTCTCGAA
GACACTGAGTGTCAGGAGGATGTCTCCAAGCGGTATGAGTGTGCCAACTTTGGAGAGCAA
GGCATCACTGTGGGTTGCTGGGATCTCTACCGGCATGACATTGACTGTCAGTGGATTGAC
ATCACGGATGTGAAGCCAGGAAACTACATTCTCCAGGTTGTCATCAACCCAAACTTTGAA
GTAGCAGAGAGTGACTTTACCAACAATGCAATGAAATGTAACTGCAAATATGATGGACAT
AGAATCTGGGTGCACAACTGCCACATTGGTGATGCCTTCAGTGAAGAGGCCAACAGGAGG
TTTGAACGCTACCCTGGCCAGACCAGCAACCAGATTATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 753 |
| Molecular Weight
| 83165.9 |
| Theoretical pI
| 6.85 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Lysyl oxidase homolog 3
MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEI
QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS
VTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRR
PLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHS
FGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK
PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA
RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLS
GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG
NITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQE
TAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHS
WVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQ
GITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGH
RIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
|
| External Links |
|---|
| GenBank ID Protein
| 14009597 |
| UniProtKB/Swiss-Prot ID
| P58215 |
| UniProtKB/Swiss-Prot Entry Name
| LOXL3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF282619 |
| GeneCard ID
| LOXL3 |
| GenAtlas ID
| LOXL3 |
| HGNC ID
| HGNC:13869 |
| References |
|---|
| General References
| - Maki JM, Kivirikko KI: Cloning and characterization of a fourth human lysyl oxidase isoenzyme. Biochem J. 2001 Apr 15;355(Pt 2):381-7. [PubMed:11284725 ]
- Jourdan-Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K: Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. Genomics. 2001 Jun 1;74(2):211-8. [PubMed:11386757 ]
- Huang Y, Dai J, Tang R, Zhao W, Zhou Z, Wang W, Ying K, Xie Y, Mao Y: Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3). Matrix Biol. 2001 Apr;20(2):153-7. [PubMed:11334717 ]
|
