Human Metabolome Database: Showing Protein COX assembly mitochondrial protein homolog (HMDBP08244)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
HMDB Protein ID	HMDBP08244
Secondary Accession Numbers	13956
Name	COX assembly mitochondrial protein homolog
Synonyms	Cmc1p
Gene Name	CMC1
Protein Type	Unknown
Biological Properties
General Function	Involved in metal ion binding
Specific Function	Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. Binds copper. May be involved in copper trafficking and distribution to COX and SOD1
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Mitochondrion
Gene Properties
Chromosome Location	Chromosome:3
Locus	3p24.1
SNPs	CMC1
Gene Sequence	>321 bp ATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCT AAAATAATGAGAGAAAAGGCCAAAGAGAGGTGTTCTGAACAAGTTCAAGATTTTACCAAA TGTTGCAAGAACTCTGGAGTTCTTATGGTAGTAAAATGCCGGAAAGAAAATTCTGCATTG AAAGAATGTCTAACTGCTTACTATAATGATCCAGCCTTTTATGAAGAATGCAAAATGGAA TACCTGAAGGAAAGGGAAGAATTCAGAAAAACTGGAATTCCTACAAAGAAAAGGCTACAG AAGCTTCCAACAAGCATGTAG
Protein Properties
Number of Residues	106
Molecular Weight	12489.5
Theoretical pI	8.81
Pfam Domain Function	Cmc1 (PF08583 )
Signals	None
Transmembrane Regions	None
Protein Sequence	>COX assembly mitochondrial protein homolog MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQDFTKCCKNSGVLMVVKCRKENSAL KECLTAYYNDPAFYEECKMEYLKEREEFRKTGIPTKKRLQKLPTSM
External Links
GenBank ID Protein	30851666
UniProtKB/Swiss-Prot ID	Q7Z7K0
UniProtKB/Swiss-Prot Entry Name	COXAM_HUMAN
PDB IDs	Not Available
GenBank Gene ID	BC052644
GeneCard ID	CMC1
GenAtlas ID	CMC1
HGNC ID	HGNC:28783
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ] Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ] Horn D, Al-Ali H, Barrientos A: Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis. Mol Cell Biol. 2008 Jul;28(13):4354-64. doi: 10.1128/MCB.01920-07. Epub 2008 Apr 28. [PubMed:18443040 ]