| Identification |
|---|
| HMDB Protein ID
| HMDBP08186 |
| Secondary Accession Numbers
| |
| Name
| H(+)/Cl(-) exchange transporter 4 |
| Synonyms
|
- Chloride channel protein 4
- Chloride transporter ClC-4
- ClC-4
|
| Gene Name
| CLCN4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.
|
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| late endosome membrane |
| early endosome membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| transporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| ion channel activity |
| anion channel activity |
| chloride channel activity |
| voltage-gated chloride channel activity |
| Molecular Function |
| voltage-gated chloride channel activity |
| antiporter activity |
| ATP binding |
| Process |
| chloride transport |
| transmembrane transport |
| inorganic anion transport |
| anion transport |
| ion transport |
| transport |
| establishment of localization |
|
| Cellular Location
|
- Late endosome membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Early endosome membrane
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xp22.3 |
| SNPs
| CLCN4 |
| Gene Sequence
|
>2283 bp
ATGGTCAATGCGGGAGCGATGAGTGGCTCTGGAAACCTGATGGATTTCCTCGATGAGCCG
TTCCCTGATGTGGGGACGTATGAGGACTTCCACACCATCGACTGGCTAAGGGAAAAGTCA
CGGGACACCGACAGACACAGGAAGATCACCAGCAAGAGCAAGGAGTCCATATGGGAGTTC
ATCAAGAGCCTGCTGGATGCCTGGTCGGGATGGGTGGTGATGCTGCTCATCGGCCTGCTG
GCGGGCACCTTGGCTGGGGTCATCGATCTCGCCGTGGACTGGATGACGGACCTGAAGGAG
GGGGTCTGCCTGTCTGCCTTCTGGTATAGCCATGAGCAGTGTTGCTGGACTTCTAACGAG
ACCACTTTTGAGGACAGAGACAAGTGTCCCCTGTGGCAGAAATGGTCGGAGCTGCTGGTG
AATCAGTCAGAGGGTGCCAGTGCTTACATTCTGAATTACTTAATGTACATCCTATGGGCG
CTGCTGTTTGCATTTTTGGCTGTCTCCCTGGTGCGTGTATTTGCACCATATCGCTGTGGC
TCTGGCATACCAGAGATAAAGACCATTTTGAGCGGCTTTATCATCAGGGGCTACTTGGGG
AAGTGGACCCTGCTAATCAAGACAGTCACGCTGGTGCTGGTAGTGTCCTCCGGTCTGAGC
CTTGGGAAGGAAGGGCCGCTAGTGCACGTGGCTTGTTGCTGTGGCAACTTCTTCAGCAGC
CTTTTCTCCAAGTACAGCAAGAATGAGGGCAAGAGGCGGGAGGTGCTTTCAGCTGCAGCG
GCTGCTGGAGTCTCTGTTGCCTTTGGTGCACCAATTGGAGGCGTGCTTTTCAGTCTAGAA
GAGGTCAGTTACTACTTTCCCCTGAAGACCTTGTGGAGGTCATTTTTCGCAGCCCTGGTG
GCGGCCTTTACGCTGAGATCCATCAATCCCTTTGGGAATAGCCGTCTCGTTCTCTTTTAT
GTGGAATACCACACGCCCTGGTACATGGCTGAACTCTTCCCCTTCATCCTGCTTGGGGTC
TTCGGGGGCTTGTGGGGAACCCTCTTCATCCGCTGCAACATCGCCTGGTGCAGGAGGCGC
AAGACCACCAGGCTGGGGAAGTACCCGGTGCTGGAGGTCATTGTGGTGACTGCCATCACT
GCCATCATTGCCTACCCCAATCCCTACACACGCCAGAGCACCAGCGAGCTCATTTCTGAG
CTGTTCAATGACTGTGGAGCCCTTGAGTCTTCCCAGCTCTGTGACTACATCAATGACCCC
AACATGACTCGGCCTGTGGATGACATTCCAGACCGGCCGGCTGGTGTCGGTGTTTACACG
GCCATGTGGCAGCTGGCCCTGGCACTGATCTTCAAAATCGTCGTTACCATATTTACCTTT
GGCATGAAGATCCCGTCGGGCCTCTTCATCCCCAGCATGGCTGTGGGCGCGATAGCGGGC
AGGATGGTGGGAATTGGCGTGGAGCAGCTGGCCTACCATCACCATGACTGGTACTACTTC
AGGAACTGGTGCAGACCCGGTGCAGACTGTGTCACGCCAGGGCTGTACGCAATGGTGGGA
GCTGCGGCCTGCCTCGGTGGAGTTACCAGGATGACGGTGTCATTGGTGGTCATCATGTTT
GAATTAACCGGGGGTCTGGAGTACATCGTGCCCCTGATGGCGGCGGCTGTGACCAGCAAG
TGGGTAGCTGATGCATTTGGGAAAGAAGGCATCTACGAGGCCCACATCCACTTAAATGGG
TACCCTTTCCTTGACGTGAAGGACGAGTTTACTCACCGCACACTGGCCACCGACGTCATG
CGGCCCCGGCGGGGAGAGCCGCCACTGTCGGTGCTCACCCAGGACAGCATGACTGTCGAG
GACGTGGAGACGCTCATCAAGGAGACCGACTACAACGGCTTCCCCGTGGTGGTCTCCAGA
GACTCCGAGCGCCTCATTGGATTTGCCCAGAGGAGGGAACTGATTCTCGCAATAAATAAC
GCCAGACAGAGGCAGGAGGGCATTGTGAGCAATTCCATCATGTACTTCACGGAGGAACCC
CCCGAGCTGCCGGCCAACAGCCCACATCCCCTGAAGCTGCGGCGCATCCTGAACCTCAGC
CCGTTTACAGTGACAGACCACACTCCGATGGAAACGGTGGTGGATATCTTCCGGAAACTG
GGGCTTCGGCAGTGCCTGGTGACGCGGAGCGGGAGACTTCTTGGCATCATCACAAAAAAG
GATGTTCTGAGACATATGGCCCAGATGGCAAACCAGGACCCCGAATCCATCATGTTTAAT
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 760 |
| Molecular Weight
| 84915.965 |
| Theoretical pI
| 6.865 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>H(+)/Cl(-) exchange transporter 4
MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEF
IKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNE
TTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACG
SGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSS
LFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV
AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRR
KTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP
NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAG
RMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMF
ELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM
RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKN
ARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKL
GLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN
|
| External Links |
|---|
| GenBank ID Protein
| 479159 |
| UniProtKB/Swiss-Prot ID
| P51793 |
| UniProtKB/Swiss-Prot Entry Name
| CLCN4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X77197 |
| GeneCard ID
| CLCN4 |
| GenAtlas ID
| CLCN4 |
| HGNC ID
| HGNC:2022 |
| References |
|---|
| General References
| - van Slegtenhorst MA, Bassi MT, Borsani G, Wapenaar MC, Ferrero GB, de Conciliis L, Rugarli EI, Grillo A, Franco B, Zoghbi HY, Ballabio A: A gene from the Xp22.3 region shares homology with voltage-gated chloride channels. Hum Mol Genet. 1994 Apr;3(4):547-52. [PubMed:8069296 ]
- Kawasaki M, Fukuma T, Yamauchi K, Sakamoto H, Marumo F, Sasaki S: Identification of an acid-activated Cl(-) channel from human skeletal muscles. Am J Physiol. 1999 Nov;277(5 Pt 1):C948-54. [PubMed:10564087 ]
- Zdebik AA, Zifarelli G, Bergsdorf EY, Soliani P, Scheel O, Jentsch TJ, Pusch M: Determinants of anion-proton coupling in mammalian endosomal CLC proteins. J Biol Chem. 2008 Feb 15;283(7):4219-27. Epub 2007 Dec 6. [PubMed:18063579 ]
|
