| Identification |
|---|
| HMDB Protein ID
| HMDBP08144 |
| Secondary Accession Numbers
| |
| Name
| Potassium voltage-gated channel subfamily H member 4 |
| Synonyms
|
- BEC2
- Brain-specific eag-like channel 2
- ELK channel 1
- ELK1
- Ether-a-go-go-like potassium channel 1
- Voltage-gated potassium channel subunit Kv12.3
|
| Gene Name
| KCNH4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| membrane |
| Function |
| transferase activity |
| two-component sensor activity |
| protein histidine kinase activity |
| voltage-gated potassium channel activity |
| potassium channel activity |
| cation channel activity |
| ion channel activity |
| protein kinase activity |
| ion transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| transmembrane transporter activity |
| transporter activity |
| catalytic activity |
| signal transducer activity |
| molecular transducer activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| Process |
| regulation of transcription |
| potassium ion transport |
| monovalent inorganic cation transport |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| transmembrane transport |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of cellular process |
| regulation of transcription, dna-dependent |
| two-component signal transduction system (phosphorelay) |
| signal transmission |
| signaling process |
| cation transport |
| ion transport |
| transport |
| establishment of localization |
| signal transduction |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q21.2 |
| SNPs
| KCNH4 |
| Gene Sequence
|
>3054 bp
ATGCCGGTCATGAAGGGGTTGCTGGCCCCGCAAAACACCTTCCTGGACACCATCGCCACC
CGTTTTGACGGAACGCACAGCAACTTCCTGCTGGCCAACGCACAGGGCACACGGGGCTTT
CCCATCGTCTACTGCTCCGACGGCTTCTGCGAGCTCACAGGCTACGGTCGCACCGAGGTC
ATGCAGAAGACCTGCAGCTGCCGTTTCCTCTACGGCCCAGAGACCAGTGAGCCAGCCCTG
CAGCGTCTGCACAAAGCCCTGGAGGGCCACCAGGAGCACCGGGCTGAAATCTGCTTCTAC
CGCAAGGATGGCTCAGCCTTTTGGTGCCTCCTGGACATGATGCCCATCAAGAATGAGATG
GGGGAGGTCGTGCTGTTCCTCTTTTCCTTCAAGGATATCACTCAGAGTGGAAGCCCAGGA
CTTGGCCCCCAAGGAGGCCGCGGGGACAGTAATCACGAAAACTCCCTTGGTAGAAGGGGA
GCCACCTGGAAATTTCGGTCTGCCAGAAGACGGAGCCGTACTGTCCTACACCGACTGACC
GGCCACTTTGGCCGCCGGGGCCAGGGAGGCATGAAGGCCAATAATAACGTGTTTGAGCCA
AAGCCATCAGTGCCCGAGTACAAGGTGGCCTCCGTGGGGGGGTCTCGCTGCCTCCTCCTC
CACTACAGCGTCTCCAAGGCCATCTGGGACGGCCTTATCCTCCTTGCCACCTTCTACGTT
GCGGTCACCGTCCCCTACAATGTCTGTTTCTCGGGTGACGATGACACCCCCATCACTTCG
CGACACACCCTTGTCAGCGACATCGCCGTGGAAATGCTCTTCATCCTAGATATCATCCTG
AACTTCCGCACCACCTATGTGTCCCAGTCCGGCCAGGTAATCTCTGCTCCTCGTTCCATT
GGCCTCCACTACCTGGCCACCTGGTTCTTCATCGACCTTATTGCTGCTCTGCCCTTTGAC
CTGCTTTACATCTTCAACATCACCGTGACCTCGCTGGTGCACCTACTGAAGACAGTGCGG
CTGTTGCGGCTGCTGCGGCTGCTGCAGAAGCTGGAGCGGTACTCTCAGTGCAGTGCTGTG
GTGCTCACGCTGCTCATGTCGGTCTTTGCGCTCCTTGCCCACTGGATGGCCTGCATCTGG
TATGTCATCGGGCGCCGGGAGATGGAGGCCAATGACCCGCTGCTCTGGGACATTGGCTGG
TTGCATGAGTTGGGCAAGCGTCTGGAGGTGCCCTATGTCAATGGCTCGGTGGGCGGCCCA
TCACGGCGCAGCGCCTACATCGCGGCACTGTACTTCACTCTAAGCAGCCTCACCAGTGTG
GGCTTTGGCAACGTGTGTGCCAACACCGACGCGGAGAAGATCTTCTCCATCTGCACGATG
CTCATAGGCGCCCTGATGCACGCTGTGGTGTTCGGGAACGTGACAGCCATCATCCAGCGC
ATGTACTCGCGCCGCTCGCTCTACCACAGCCGCATGAAGGACCTCAAGGACTTCATCCGT
GTGCACCGCCTGCCGCGGCCGCTCAAGCAGCGCATGCTCGAATACTTCCAGACCACGTGG
GCCGTCAACAGCGGCATCGACGCCAACGAGTTACTGCGTGACTTCCCAGACGAGCTGAGA
GCTGACATTGCTATGCACCTGAATCGGGAGATCCTGCAGCTGCCGTTGTTCGGGGCAGCG
AGCAGGGGCTGCCTGCGGGCCCTATCGCTGCACATCAAGACCTCGTTCTGCGCTCCGGGC
GAGTACCTGTTGCGCCGTGGGGATGCCCTGCAGGCACATTACTATGTCTGCTCCGGCTCG
CTTGAGGTGCTCCGAGACAACATGGTGCTGGCCATCCTGGGGAAGGGGGACCTGATTGGA
GCAGATATCCCTGAGCCGGGGCAGGAGCCTGGGTTGGGAGCAGACCCAAACTTCGTGCTA
AAGACCAGTGCTGATGTGAAAGCTCTGACCTACTGTGGCCTGCAGCAGCTGAGCAGCCGA
GGGCTGGCTGAGGTCCTGAGGCTCTATCCTGAGTATGGGGCTGCCTTCCGGGCTGGCCTG
CCCCGGGACCTCACCTTCAACCTGCGCCAGGGCTCTGACACCAGTGGCCTCAGCCGCTTT
TCCCGATCCCCTCGCCTCTCCCAGCCCCGCTCAGAAAGCCTCGGCTCCTCCTCAGACAAG
ACGCTGCCATCCATCACAGAGGCCGAGAGTGGCGCGGAGCCTGGGGGTGGTCCCAGGCCC
CGACGGCCCCTCCTGCTGCCCAACCTCAGCCCAGCACGGCCTCGGGGCTCCCTGGTCAGC
CTTTTGGGCGAGGAGCTGCCCCCATTCTCAGCCCTTGTCTCCTCTCCTTCCTTATCCCCA
TCCCTGTCCCCTGCCCTGGCTGGCCAGGGCCACAGTGCCTCCCCTCACGGCCCCCCCAGG
TGCTCTGCTGCCTGGAAGCCCCCTCAGCTTCTCATTCCCCCACTGGGAACCTTTGGACCT
CCGGACCTCAGTCCCCGGATAGTGGATGGCATTGAGGACTCTGGCAGCACAGCTGAGGCC
CCTTCATTCCGATTCAGCAGGAGGCCTGAACTGCCAAGGCCCCGCTCCCAGGCGCCCCCT
ACAGGGACCAGGCCCAGCCCAGAATTGGCCAGTGAGGCTGAGGAGGTGAAGGAAAAGGTT
TGCCGGCTGAACCAGGAGATCTCTCGTCTCAATCAGGAGGTGTCTCAGCTTAGCCGGGAG
CTGCGGCACATCATGGGCCTGCTGCAGGCCAGGCTGGGTCCCCCAGGCCACCCAGCAGGC
TCCGCTTGGACCCCAGACCCTCCTTGTCCACAGCTGAGGCCACCATGCCTCTCTCCTTGT
GCGTCCAGACCACCACCCAGCCTCCAGGATACTACGCTTGCTGAAGTTCACTGCCCAGCC
AGTGTGGGGACCATGGAGACAGGGACTGCGCTCCTGGACTTGAGACCTTCCATATTGCCC
CCCTACCCCTCAGAGCCTGACCCTCTGGGACCCTCTCCAGTGCCAGAGGCCTCACCCCCA
ACCCCAAGCCTCTTGAGGCACAGTTTCCAGTCCAGGTCAGACACGTTCCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1017 |
| Molecular Weight
| 111692.1 |
| Theoretical pI
| 8.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 229-249
- 260-280
- 303-323
- 333-353
- 362-382
- 483-503
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily H member 4
MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV
MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM
GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT
GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV
AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI
GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV
VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP
SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQR
MYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR
ADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGS
LEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSR
GLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK
TLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSP
SLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA
PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRE
LRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPA
SVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9UQ05 |
| UniProtKB/Swiss-Prot Entry Name
| KCNH4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB022698 |
| GeneCard ID
| KCNH4 |
| GenAtlas ID
| KCNH4 |
| HGNC ID
| HGNC:6253 |
| References |
|---|
| General References
| - Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
- Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K: New ether-a-go-go K(+) channel family members localized in human telencephalon. J Biol Chem. 1999 Aug 27;274(35):25018-25. [PubMed:10455180 ]
|
