Hmdb loader
Identification
HMDB Protein ID HMDBP08055
Secondary Accession Numbers
  • 13766
Name Trimeric intracellular cation channel type A
Synonyms
  1. TRIC-A
  2. TRICA
  3. Transmembrane protein 38A
Gene Name TMEM38A
Protein Type Unknown
Biological Properties
General Function Involved in cation channel activity
Specific Function Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
ion channel activity
cation channel activity
Process
establishment of localization
transport
ion transport
cation transport
monovalent inorganic cation transport
Cellular Location
  1. Multi-pass membrane protein
  2. Sarcoplasmic reticulum membrane
  3. Nucleus membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.11
SNPs TMEM38A
Gene Sequence
>900 bp
ATGGAGCTGCTCTCGGCGCTGAGCCTGGGCGAACTGGCGCTCAGCTTCTCGCGGGTGCCG
CTCTTCCCCGTCTTCGACCTCAGTTACTTCATCGTCTCCATCCTCTACCTCAAGTATGAG
CCAGGAGCAGTCGAACTGTCCCGGCGCCACCCCATCGCGTCCTGGCTGTGCGCCATGCTG
CATTGCTTCGGGAGCTACATCCTGGCTGATCTGCTCCTTGGGGAGCCACTGATCGATTAC
TTCAGCAACAACTCCAGCATCCTGCTGGCCTCAGCTGTCTGGTACTTGATTTTCTTCTGC
CCCCTGGACCTCTTCTACAAGTGTGTCTGCTTCCTGCCTGTGAAACTCATCTTCGTGGCC
ATGAAGGAGGTGGTGCGAGTCCGCAAGATCGCGGTGGGCATCCATCACGCCCATCACCAC
TACCACCACGGGTGGTTCGTCATGATTGCAACTGGGTGGGTCAAAGGTTCTGGTGTCGCC
CTCATGTCCAACTTTGAGCAGCTGCTCCGAGGGGTCTGGAAGCCAGAGACCAACGAGATC
CTGCACATGTCTTTCCCCACCAAGGCCAGCCTGTATGGAGCCATCCTCTTCACCCTCCAG
CAGACCCGCTGGCTCCCAGTGTCCAAAGCCAGCCTCATCTTCATCTTCACCTTGTTCATG
GTGTCCTGTAAGGTGTTTCTGACAGCCACCCACTCACACAGCTCCCCCTTTGATGCCCTG
GAGGGCTACATCTGCCCCGTGCTGTTTGGTTCGGCCTGCGGGGGTGACCATCACCACGAC
AACCATGGTGGGTCCCACAGCGGTGGTGGGCCAGGAGCTCAGCATTCGGCCATGCCCGCC
AAGTCCAAGGAGGAGTTGAGCGAGGGCTCCAGGAAGAAGAAGGCCAAGAAGGCGGATTAG
Protein Properties
Number of Residues 299
Molecular Weight 33259.6
Theoretical pI 8.41
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 52-72
  • 86-106
  • 145-165
  • 210-230
Protein Sequence
>Trimeric intracellular cation channel type A
MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
GenBank ID Protein 10438670
UniProtKB/Swiss-Prot ID Q9H6F2
UniProtKB/Swiss-Prot Entry Name TM38A_HUMAN
PDB IDs Not Available
GenBank Gene ID AK025981
GeneCard ID TMEM38A
GenAtlas ID TMEM38A
HGNC ID HGNC:28462
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Yazawa M, Ferrante C, Feng J, Mio K, Ogura T, Zhang M, Lin PH, Pan Z, Komazaki S, Kato K, Nishi M, Zhao X, Weisleder N, Sato C, Ma J, Takeshima H: TRIC channels are essential for Ca2+ handling in intracellular stores. Nature. 2007 Jul 5;448(7149):78-82. [PubMed:17611541 ]