Human Metabolome Database: Showing Protein Synaptotagmin-10 (HMDBP08025)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08025

Secondary Accession Numbers

13736

Name

Synaptotagmin-10

Synonyms

Synaptotagmin X
SytX

Gene Name

SYT10

Protein Type

Unknown

Biological Properties

General Function

Involved in transporter activity

Specific Function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
organelle
membrane
vesicle
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
coated vesicle
clathrin-coated vesicle
synaptic vesicle
Function
transporter activity
Process
establishment of localization
transport

Cellular Location

Cytoplasmic vesicle
Single-pass membrane protein
secretory vesicle
synaptic vesicle membrane

Gene Properties

Chromosome Location

Chromosome:1

Locus

12p11.1

SNPs

SYT10

Gene Sequence

>1572 bp
ATGAGTTTCCACAAGGAGGACGGAGTGAACAGTCTGTGCCAGAAGGCTCTGCACATCGTC
ACCGAGCTGTGCTTCGCCGGCCAGGTGGAGTGGGAGAAGTGCTCGGGCATCTTCCCTCGG
GACAGGGGCAGCCAGGGCGGAAGCAGCACAGATATTTCAGTCAGCCTGTTAGCTGTCGTT
GTCAGCTTTTGTGGACTGGCCTTGTTGGTTGTCTCACTTTTTGTCTTCTGGAAGCTGTGT
TGGCCATGCTGGAAAAGCAAACCTGTGACTTCCAACATCACTACGCTTCCACAGAGCATT
TCAAGTGCTCCTACTGAAGTTTTTGAGACTGAAGAGAAAAAAGAAATTAAGGAAAATGAA
AAGCCAGCCGTAAAAGCTATTGAGCCTGCAATAAAAATCAGCCACACTTCCCCTGACATC
CCAGCAGAAGTCCAAACTGCTTTAAAAGAACATTTAATTAAACATGCACGTGTGCAAAGA
CAAATTACTGAGCCTACGTCATCAACCCGCCACAGTTCCTTCCGAAGACACCTGCCGAGG
CAAATGCAGGTTTCCAGTGTTGATTTTAGCATGGGCACAGAACCTGTTTTACAACGAGGA
GAAACAACAACCAGCATTGGGAGGATAAAGCCAGAACTCTACAAACAGAAATCAGTTGAC
TCTGAGGGCAACCAAAACGAAGATGTCAAAATCTGTGGGAAACTTAACTTTACCCTCCAG
TATGATTATGAAAATGAACTTCTAGTTGTTAAAATTATCAAAGCTTTAGATCTCCCTGCT
AAAGACTTCACAGGAACTTCTGACCCTTATGTGAAGATGTATCTTCTTCCAGATAGGAAA
AAGAAATTTCAGACCCGCGTGCACAGAAAGACTTTAAATCCTCTATTTGATGAAACTTTT
CAATTTCCTGTGGCATATGATCAACTAAGCAACCGAAAACTACATTTCAGTGTGTATGAT
TTTGACAGATTTTCTAGACATGACATGATTGGGGAAGTGATTCTTGATAATTTGTTTGAA
GTCTCTGATCTCTCCAGGGAAGCCACAGTATGGAAAGATATTCACTGTGCTACCACAGAA
AGTATAGACCTGGGTGAAATCATGTTTTCCCTTTGTTACCTACCGACGGCTGGGCGTATG
ACATTGACAGTCATTAAGTGCAGAAATCTGAAGGCGATGGATATTACTGGCTCATCAGAT
CCTTATGTCAAAGTGTCCCTGATGTGTGAAGGTCGAAGATTAAAAAAGAGGAAAACAACT
ACAAAGAAAAACACTCTAAACCCTGTGTACAATGAGGCCATTATTTTTGACATCCCTCCA
GAGAACGTGGACCAGGTCAGCCTCTCCATTGCGGTCATGGATTACGATAGGGTAGGACAC
AATGAGGTCATAGGAGTGTGCAGAACAGGACTGGATGCTGAGGGTCTTGGGCGAGACCAC
TGGAATGAAATGCTGGCCTATCATCGAAAACCAATAACGCACTGGCACCCATTGCTGGAG
TTACCTGGCCGGGCGACCAGTTTTGATAGTCAAGGATCCTGCCCTTCTCCTAAACCACCT
TCCACACCATAA

Protein Properties

Number of Residues

523

Molecular Weight

59126.3

Theoretical pI

7.7

Pfam Domain Function

C2 (PF00168 )

Signals

None

Transmembrane Regions

56-76

Protein Sequence

>Synaptotagmin-10
MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVV
VSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENE
KPAVKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPR
QMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQ
YDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETF
QFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTE
SIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTT
TKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDH
WNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP

External Links

GenBank ID Protein

37781775

UniProtKB/Swiss-Prot ID

Q6XYQ8

UniProtKB/Swiss-Prot Entry Name

SYT10_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Zhao E, Li Y, Fu X, Zeng L, Zeng H, Jin W, Chen J, Yin G, Qian J, Ying K, Xie Y, Zhao RC, Mao Y: Cloning and characterization of human synaptotagmin 10 gene. DNA Seq. 2003 Oct;14(5):393-8. [PubMed:14756426 ]