Human Metabolome Database: Showing Protein Synaptic vesicle glycoprotein 2C (HMDBP08022)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08022

Secondary Accession Numbers

13733

Name

Synaptic vesicle glycoprotein 2C

Synonyms

Not Available

Gene Name

SV2C

Protein Type

Unknown

Biological Properties

General Function

Involved in transmembrane transport

Specific Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane
membrane part
intrinsic to membrane
integral to membrane
Function
transporter activity
Process
establishment of localization
transport
transmembrane transport

Cellular Location

Cytoplasmic vesicle
Multi-pass membrane protein
secretory vesicle
synaptic vesicle membrane

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q13.3

SNPs

SV2C

Gene Sequence

>2184 bp
ATGGAAGACTCTTACAAGGATAGGACTTCACTGATGAAGGGTGCCAAGGACATTGCCAGA
GAGGTGAAGAAACAAACAGTAAAGAAGGTGAATCAAGCTGTGGACCGAGCCCAGGATGAA
TACACCCAGAGGTCCTACAGTCGGTTCCAAGATGAAGAAGATGATGATGACTACTACCCG
GCTGGAGAAACCTATAATGGTGAGGCCAACGATGACGAAGGCTCAAGTGAAGCCACTGAG
GGGCATGATGAAGATGATGAGATCTATGAGGGGGAGTATCAGGGCATCCCCAGTATGAAC
CAAGCGAAGGACAGCATCGTGTCAGTGGGGCAGCCCAAGGGCGATGAGTACAAGGACCGA
CGGGAGCTGGAATCAGAAAGGAGAGCTGACGAGGAAGAGTTAGCCCAGCAGTATGAGCTG
ATAATCCAAGAATGCGGTCATGGTCGTTTTCAGTGGGCCCTTTTCTTCGTCCTGGGCATG
GCTCTTATGGCAGACGGTGTAGAGGTGTTTGTCGTTGGCTTCGTGTTACCCAGTGCTGAG
ACAGACCTCTGCATCCCAAATTCAGGATCTGGATGGCTAGGCAGCATAGTGTACCTCGGG
ATGATGGTGGGGGCGTTCTTCTGGGGAGGACTGGCAGACAAAGTGGGAAGGAAACAGTCT
CTTCTGATTTGCATGTCTGTCAACGGATTCTTTGCCTTCCTTTCTTCATTTGTCCAAGGT
TATGGCTTCTTTCTCTTCTGTCGCTTACTTTCTGGATTCGGGATTGGAGGAGCCATACCC
ACTGTGTTCTCGTACTTTGCTGAAGTCCTGGCCCGGGAAAAGCGGGGCGAACACTTGAGC
TGGCTCTGCATGTTCTGGATGATCGGTGGCATCTACGCCTCTGCCATGGCCTGGGCCATC
ATCCCGCACTACGGGTGGAGCTTCAGCATGGGATCGGCCTACCAGTTTCACAGTTGGCGT
GTGTTTGTCATCGTCTGTGCACTCCCCTGTGTCTCCTCCGTGGTGGCCCTCACATTCATG
CCTGAAAGCCCACGATTCTTGTTGGAGGTTGGAAAACATGATGAAGCTTGGATGATTCTG
AAGTTAATTCATGACACCAACATGAGAGCCCGGGGTCAGCCTGAGAAGGTCTTCACGGTA
AACAAAATAAAAACTCCTAAACAAATAGATGAGCTGATTGAAATTGAGAGTGACACAGGA
ACATGGTATAGGAGGTGTTTTGTTCGGATCCGCACCGAGCTGTACGGAATTTGGTTGACT
TTTATGAGATGTTTCAACTACCCAGTCAGGGATAATACAATAAAGCTTACAATTGTTTGG
TTCACCCTGTCCTTTGGGTACTATGGATTATCCGTTTGGTTCCCTGATGTCATTAAACCT
CTGCAGTCCGATGAATATGCATTGCTAACCAGAAATGTGGAGAGAGATAAATATGCAAAT
TTCACTATTAACTTTACAATGGAAAATCAGATTCATACTGGAATGGAATACGACAATGGC
AGATTCATAGGGGTCAAGTTCAAATCTGTAACTTTCAAAGACTCTGTTTTTAAGTCCTGC
ACCTTTGAGGATGTAACTTCAGTGAACACCTACTTCAAGAACTGCACATTTATTGACACT
GTTTTTGACAACACAGATTTTGAGCCATATAAATTCATTGACAGTGAATTTAAAAACTGC
TCGTTTTTTCACAACAAGACGGGATGTCAGATTACCTTTGATGATGACTATAGTGCCTAC
TGGATTTATTTTGTCAACTTTCTGGGGACATTGGCAGTATTGCCAGGGAACATTGTGTCT
GCTCTGCTGATGGACAGAATTGGGCGCTTAACAATGCTAGGTGGCTCTATGGTGCTTTCG
GGGATCAGCTGTTTCTTCCTTTGGTTCGGCACCAGTGAATCCATGATGATAGGCATGCTG
TGTCTGTACAATGGATTGACCATCTCAGCCTGGAACTCTCTTGACGTGGTCACTGTGGAA
CTGTACCCCACAGACCGGAGGGCAACAGGCTTTGGCTTCTTAAATGCGCTATGCAAGGCA
GCAGCCGTCCTGGGAAACTTAATATTTGGCTCTCTGGTCAGCATCACCAAATCAATCCCC
ATCCTGCTGGCTTCTACTGTGCTCGTGTGTGGAGGACTCGTTGGGCTGTGCCTGCCTGAC
ACACGAACCCAGGTTCTGATGTAA

Protein Properties

Number of Residues

727

Molecular Weight

82341.5

Theoretical pI

4.67

Pfam Domain Function

MFS_1 (PF07690 )
Sugar_tr (PF00083 )

Signals

None

Transmembrane Regions

155-175
192-212
227-247
249-269
281-301
321-341
438-458
579-599
610-630
637-657
670-690
699-719

Protein Sequence

>Synaptic vesicle glycoprotein 2C
MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYP
AGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDR
RELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE
TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQG
YGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAI
IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL
KLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLT
FMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN
FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDT
VFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVS
ALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE
LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD
TRTQVLM

External Links

GenBank ID Protein

73695465

UniProtKB/Swiss-Prot ID

Q496J9

UniProtKB/Swiss-Prot Entry Name

SV2C_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Jun 30;6(3):197-205. [PubMed:10470851 ]