Hmdb loader
Identification
HMDB Protein ID HMDBP08018
Secondary Accession Numbers
  • 13729
Name Syntaxin-binding protein 5
Synonyms
  1. Lethal(2) giant larvae protein homolog 3
  2. Tomosyn-1
Gene Name STXBP5
Protein Type Unknown
Biological Properties
General Function Involved in vesicle-mediated transport
Specific Function Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
establishment of localization
transport
vesicle-mediated transport
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Peripheral membrane protein
  4. Peripheral membrane protein
  5. Cytoplasmic vesicle
  6. secretory vesicle
  7. Cell junction
  8. synapse
  9. Cytoplasmic vesicle membrane
  10. synaptic vesicle
Gene Properties
Chromosome Location Chromosome:6
Locus 6q24.3
SNPs STXBP5
Gene Sequence
>3456 bp
ATGAGGAAATTCAACATCAGGAAGGTGCTGGACGGCCTGACCGCCGGCTCGTCCTCGGCG
TCGCAGCAGCAACAGCAGCAGCATCCGCCTGGGAACCGGGAGCCGGAGATCCAGGAAACG
CTCCAGTCCGAGCACTTTCAGCTCTGCAAGACTGTTCGCCATGGATTTCCCTATCAACCC
TCAGCCCTGGCCTTTGATCCTGTACAGAAGATCCTGGCAGTGGGAACTCAGACTGGTGCT
TTAAGGCTCTTTGGTCGTCCAGGAGTAGAATGTTATTGCCAGCATGACAGTGGAGCTGCA
GTAATCCAGCTCCAGTTCCTGATTAATGAGGGAGCGCTTGTGAGTGCCTTGGCTGATGAC
ACCTTACACTTATGGAATTTACGTCAGAAGAGGCCTGCCATACTACATTCGCTTAAATTT
TGCAGAGAAAGGGTTACATTTTGCCATCTGCCTTTCCAGAGTAAGTGGCTCTATGTGGGC
ACTGAACGAGGTAATATACATATTGTCAATGTGGAGTCCTTCACACTCTCAGGCTACGTC
ATTATGTGGAATAAAGCCATTGAACTGTCATCTAAATCTCACCCAGGACCTGTGGTCCAT
ATAAGTGATAATCCAATGGACGAGGGAAAGCTTTTGATTGGCTTTGAATCTGGAACAGTA
GTTTTATGGGACCTCAAATCAAAGAAAGCCGACTACAGATACACATATGATGAGGCTATC
CACTCTGTTGCTTGGCATCATGAAGGAAAACAATTTATTTGCAGTCATTCAGATGGCACC
TTGACTATATGGAATGTAAGGTCCCCTGCTAAACCAGTACAGACAATCACTCCACATGGA
AAACAGTTAAAGGATGGGAAGAAGCCAGAACCATGCAAACCTATCCTCAAGGTGGAATTC
AAAACGACTAGATCTGGGGAGCCTTTTATTATTTTATCAGGAGGTTTGTCATATGATACT
GTAGGAAGAAGACCTTGCTTAACAGTGATGCATGGGAAAAGCACTGCTGTGCTAGAAATG
GACTATTCAATTGTTGATTTTCTAACGCTGTGTGAAACACCATACCCAAATGATTTTCAA
GAACCATATGCTGTGGTTGTTCTTCTAGAAAAGGATTTAGTACTTATAGACCTTGCACAA
AATGGATATCCTATATTTGAAAATCCCTACCCTTTGAGTATACATGAGTCCCCTGTTACA
TGTTGCGAATATTTTGCGGATTGTCCTGTGGACCTTATTCCTGCACTTTATTCTGTTGGA
GCTAGACAGAAACGTCAAGGTTACAGCAAAAAGGAATGGCCCATCAACGGAGGTAATTGG
GGCTTGGGTGCTCAAAGTTACCCAGAAATAATTATTACAGGGCATGCTGATGGGTCAGTT
AAGTTCTGGGATGCTTCTGCAATAACTCTACAAGTATTATATAAGCTAAAGACATCTAAA
GTATTTGAAAAGTCAAGAAATAAAGATGACAGGCCAAACACAGACATTGTAGATGAAGAT
CCATATGCCATTCAGATCATCTCCTGGTGTCCAGAAAGTAGAATGCTGTGCATCGCTGGA
GTTTCAGCTCATGTCATTATTTATAGATTCAGCAAGCAGGAAGTAATCACAGAAGTCATT
CCGATGCTTGAAGTTCGATTATTATATGAGATAAATGATGTGGAAACTCCGGAGGGTGAG
CAGCCACCACCTTTGCCAACACCCGTGGGAGGGTCCAACCCTCAGCCCATCCCTCCTCAG
TCTCATCCATCTACCAGTAGCAGTTCATCTGATGGGCTTCGTGATAATGTACCTTGTTTA
AAAGTTAAAAACTCACCACTTAAACAGTCTCCAGGTTATCAAACAGAACTAGTTATTCAG
TTGGTTTGGGTGGGTGGAGAACCACCACAACAAATAACCAGCCTGGCAGTCAATTCTTCC
TATGGACTGGTGGTTTTTGGCAATTGCAATGGCATTGCTATGGTTGACTACCTCCAGAAA
GCAGTGCTGCTCAACCTGGGCACTATTGAATTATATGGCTCTAATGATCCTTATCGGAGA
GAACCCCGATCTCCTCGTAAATCTCGACAGCCTTCAGGAGCCGGTCTGTGTGATATTAGT
GAAGGGACTGTTGTTCCAGAGGATCGCTGCAAATCTCCAACCTCTGGTTCTTCATCACCA
CACAATTCAGATGATGAACAAAAAATGAATAATTTTATAGAAAAGGTGAAGACCAAAAGC
AGAAAGTTTTCCAAGATGGTAGCCAATGATATAGCAAAGATGTCAAGGAAGTTAAGCTTA
CCTACTGACCTAAAGCCTGATTTAGATGTAAAGGATAACTCCTTTAGCCGATCACGGAGT
TCAAGTGTAACAAGCATTGACAAAGAATCCCGAGAAGCGATCTCCGCTCTTCATTTCTGT
GAAACGTTTACTCGAAAGACGGACTCGTCCCCTTCCCCTTGTCTATGGGTTGGAACAACG
CTAGGAACAGTGCTTGTCATTGCACTGAACCTTCCCCCAGGGGGAGAGCAAAGACTTCTT
CAGCCAGTAATTGTGTCTCCAAGTGGTACTATATTGAGGTTAAAAGGTGCAATCTTGAGA
ATGGCATTTCTGGATACCACAGGCTGCTTAATACCACCTGCGTATGAACCCTGGAGAGAG
CACAATGTTCCTGAAGAAAAAGACGAAAAGGAGAAATTGAAAAAACGGCGGCCTGTCTCA
GTATCCCCCTCCTCTTCTCAGGAAATTAGTGAAAACCAGTATGCAGTGATATGTTCTGAA
AAGCAAGCAAAAGTAATCTCACTGCCAACCCAGAACTGTGCTTATAAGCAAAATATTACA
GAGACCTCGTTTGTGCTTCGTGGAGATATTGTAGCATTGAGTAACAGTATCTGCCTTGCC
TGTTTCTGTGCCAATGGACATATAATGACTTTTAGTTTGCCAAGTTTAAGACCTCTGTTG
GATGTGTATTACTTGCCCCTTACCAATATGCGGATAGCCAGAACGTTCTGCTTTACCAAC
AATGGACAAGCATTATACCTTGTTTCACCTACAGAAATCCAGAGACTTACTTATAGTCAA
GAGACCTGTGAAAATCTTCAGGAAATGTTGGGTGAACTCTTCACTCCTGTAGAAACACCT
GAAGCACCAAACAGGGGATTCTTTAAAGGCTTATTTGGAGGTGGTGCACAATCTCTTGAC
AGAGAAGAACTATTTGGAGAATCGTCCTCAGGAAAGGCTTCAAGGAGCCTTGCACAGCAT
ATTCCTGGCCCTGGTGGCATTGAAGGCGTAAAAGGGGCAGCATCTGGAGTTGTTGGTGAA
TTAGCACGAGCCAGGCTGGCACTAGATGAAAGAGGGCAGAAACTTGGCGATCTGGAAGAA
AGAACTGCGGCCATGTTATCAAGTGCAGAGTCATTTTCTAAACATGCTCATGAGATTATG
TTGAAATACAAAGATAAGAAGTGGTACCAGTTCTGA
Protein Properties
Number of Residues 1151
Molecular Weight 127571.5
Theoretical pI 7.3
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Syntaxin-binding protein 5
MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP
SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD
TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV
IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI
HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF
KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ
EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG
ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK
VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI
PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL
KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK
AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSP
HNSDDEQKMNNFIEKVKTKSRKFSKMVANDIAKMSRKLSLPTDLKPDLDVKDNSFSRSRS
SSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLL
QPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVS
VSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLA
CFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQ
ETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQH
IPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIM
LKYKDKKWYQF
GenBank ID Protein 189217915
UniProtKB/Swiss-Prot ID Q5T5C0
UniProtKB/Swiss-Prot Entry Name STXB5_HUMAN
PDB IDs
GenBank Gene ID NM_001127715.1
GeneCard ID STXBP5
GenAtlas ID STXBP5
HGNC ID HGNC:19665
References
General References
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