Human Metabolome Database: Showing Protein Peroxidasin-like protein (HMDBP07960)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 metabolites

Identification

HMDB Protein ID

HMDBP07960

Secondary Accession Numbers

13671

Name

Peroxidasin-like protein

Synonyms

Cardiac peroxidase
Vascular peroxidase 2
polysomal ribonuclease 1
PRM1

Gene Name

PXDNL

Protein Type

Unknown

Biological Properties

General Function

Involved in peroxidase activity

Specific Function

Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.

Pathways

Not Available

Reactions

phenolic donor + Hydrogen peroxide → phenoxyl radical of the donor + Water

details

GO Classification

Biological Process
nucleic acid phosphodiester bond hydrolysis
hydrogen peroxide catabolic process
Cellular Component
extracellular space
cytoplasm
Function
cation binding
peroxidase activity
heme binding
antioxidant activity
iron ion binding
protein binding
transition metal ion binding
binding
metal ion binding
ion binding
Molecular Function
metal ion binding
heme binding
peroxidase activity
endonuclease activity
Process
oxidation reduction
response to stimulus
response to stress
response to oxidative stress
metabolic process

Cellular Location

Secreted (Potential)

Gene Properties

Chromosome Location

Locus

8q11.22-q11.23

SNPs

PXDNL

Gene Sequence

>4392 bp
ATGGAGCCCAGACTGTTCTGCTGGACCACTCTCTTTCTCCTGGCCGGGTGGTGCCTGCCA
GGGTTGCCCTGCCCCAGCCGGTGCCTTTGCTTTAAGAGCACCGTCCGCTGCATGCACTTG
ATGCTGGACCACATTCCTCAGGTACCACAGCAGACCACAGTTCTAGACTTGAGGTTTAAC
AGAATAAGAGAAATTCCAGGGAGCGCCTTCAAGAAACTCAAGAATTTGAACACACTTCTG
CTGAACAACAACCACATCAGAAAGATTTCCAGAAATGCTTTTGAAGGACTTGAAAATTTG
CTATATCTGTACCTGTATAAGAATGAAATCCATGCACTAGATAAGCAAACATTTAAAGGA
CTCATATCTTTGGAACATCTGTATATTCATTTCAACCAACTAGAAATGCTACAGCCAGAG
ACCTTTGGAGACCTTCTGAGATTAGAGCGACTATTTTTGCATAACAACAAATTATCTAAA
ATTCCAGCTGGGAGCTTTTCTAATCTGGATTCATTAAAAAGATTGCGTCTGGATTCCAAC
GCCCTGGTTTGTGACTGTGATCTGATGTGGCTGGGGGAGCTTTTACAAGGCTTTGCCCAA
CACGGCCACACCCAGGCTGCGGCTACCTGCGAATATCCCAGGAGACTCCATGGGCGTGCA
GTTGCTTCAGTAACAGTAGAGGAATTCAATTGCCAGAGCCCCCGAATTACTTTTGAGCCG
CAGGATGTGGAGGTACCATCAGGAAATACCGTCTACTTCACCTGCCGGGCGGAAGGAAAC
CCCAAACCTGAGATTATTTGGATACACAACAACCACTCATTGGATTTGGAAGATGATACT
CGACTTAATGTGTTTGATGATGGCACACTCATGATCCGAAACACCAGAGAGTCAGACCAA
GGTGTCTATCAGTGCATGGCCAGAAATTCCGCTGGGGAAGCCAAGACACAGAGTGCCATG
CTCAGATACTCCAGTCTTCCAGCCAAACCAAGCTTTGTAATCCAGCCTCAGGACACAGAG
GTTTTAATTGGCACCAGCACAACTTTGGAATGTATGGCCACAGGCCACCCACACCCTCTT
ATCACTTGGACCAGGGACAATGGATTGGAGCTGGATGGATCCAGGCACGTGGCAACGTCC
AGTGGACTTTACTTACAGAACATCACACAACGGGATCATGGTCGATTTACCTGTCATGCC
AACAATAGCCACGGCACTGTTCAAGCTGCAGCAAACATAATTGTACAAGCTCCTCCACAA
TTTACAGTAACCCCCAAGGATCAAGTGGTGCTGGAAGAACATGCTGTAGAGTGGCTCTGT
GAAGCTGACGGCAACCCACCTCCTGTTATTGTCTGGACAAAAACAGGAGGGCAGCTCCCT
GTGGAAGGCCAGCATACAGTTCTCTCCTCTGGCACTTTGAGAATTGACCGTGCAGCACAG
CACGATCAAGGCCAATATGAATGTCAAGCAGTCAGTTCGTTGGGGGTGAAAAAGGTGTCT
GTGCAGCTGACTGTAAAACCCAAAGCTCTTGCAGTGTTTACTCAACTTCCTCAGGATACA
AGTGTCGAGGTTGGAAAGAATATAAACATTTCATGTCATGCTCAAGGAGAACCACAGCCC
ATAATTACTTGGAATAAGGAAGGTGTGCAGATTACTGAGAGTGGTAAATTCCATGTGGAT
GATGAAGGCACGCTGACTATCTACGACGCAGGGTTCCCTGACCAGGGAAGATATGAATGT
GTGGCTCGGAATTCTTTTGGCCTTGCTGTGACCAACATGTTTCTTACAGTCACGGCTATA
CAGGGTAGACAAGCTGGCGATGACTTTGTTGAATCTTCCATTCTTGATGCTGTACAGAGA
GTTGACAGTGCAATTAACTCCACACGAAGACATTTGTTTTCACAAAAACCTCACACCTCC
AGTGACCTGCTGGCTCAATTTCATTACCCGCGTGACCCACTGATTGTGGAAATGGCAAGA
GCAGGGGAGATTTTTGAGCACACGCTGCAGCTGATACGGGAACGTGTGAAGCAGGGGCTC
ACTGTGGACTTGGAAGGCAAAGAATTCCGGTACAATGACTTGGTGTCCCCGCGCTCCCTC
AGCCTCATCGCCAATTTATCTGGATGCACAGCTCGCAGGCCTCTGCCAAACTGCTCCAAC
CGGTGTTTCCATGCGAAGTACCGCGCCCACGACGGCACGTGCAACAACCTGCAGCAGCCC
ACGTGGGGCGCGGCGCTGACCGCCTTCGCGCGCCTGCTGCAGCCAGCCTACCGGGACGGC
ATCCGCGCGCCCCGCGGGCTCGGCCTTCCTGTGGGCTCCCGCCAGCCCCTCCCGCCGCCC
CGGCTGGTCGCCACAGTGTGGGCGCGCGCGGCGGCCGTCACCCCCGACCACAGCTACACG
CGCATGCTCATGCACTGGGGCTGGTTTCTAGAGCACGACTTGGACCACACAGTGCCTGCG
CTGAGCACAGCCCGCTTCTCGGATGGGCGGCCGTGCAGCTCCGTCTGCACCAACGACCCT
CCTTGTTTCCCCATGAACACCCGGCACGCCGACCCCCGGGGCACCCACGCGCCCTGCATG
CTCTTCGCGCGCTCCAGCCCCGCGTGTGCCAGCGGCCGTCCCTCTGCGACGGTGGATTCA
GTCTATGCACGAGAGCAGATCAACCAGCAAACAGCCTACATCGATGGCTCCAACGTTTAC
GGGAGCTCGGAGCGGGAATCCCAGGCTCTCAGAGACCCTTCGGTGCCTCGGGGTCTCCTG
AAGACAGGCTTTCCTTGGCCTCCCTCCGGAAAGCCCTTATTGCCCTTTTCTACAGGCCCA
CCCACCGAGTGCGCGCGACAGGAGCAGGAGAGCCCCTGTTTCCTGGCCGGGGACCACCGG
GCCAACGAGCATCTGGCTCTGGCCGCCATGCACACCCTGTGGTTCCGGGAACACAACAGG
GTGGCCACGGAGCTGTCCGCCCTGAACCCCCACTGGGAGGGAAACACGGTTTACCAGGAA
GCCAGGAAGATCGTGGGCGCGGAGCTGCAGCACATCACCTACAGCCACTGGCTGCCTAAG
GTCCTGGGGGACCCTGGCACTAGGATGCTGAGGGGTTACCGAGGCTACAACCCCAACGTG
AATGCAGGCATCATTAACTCTTTTGCTACTGCAGCCTTTAGATTTGGCCACACATTAATC
AATCCTATTCTTTACCGACTGAATGCCACCTTAGGTGAAATTTCCGAAGGCCACCTTCCG
TTCCATAAAGCGCTCTTTTCACCGTCCAGAATAATCAAGGAAGGTGGGATAGACCCGGTT
CTCCGGGGGCTGTTTGGCGTGGCTGCTAAATGGCGGGCACCCTCCTACCTTCTCAGTCCT
GAGCTGACCCAGAGGCTCTTCTCCGCGGCTTATTCTGCGGCCGTGGATTCGGCTGCCACC
ATCATTCAAAGGGGTAGAGACCACGGGATCCCACCATATGTTGACTTCAGAGTTTTCTGT
AATTTGACTTCAGTTAAGAACTTTGAGGATCTTCAAAATGAAATTAAAGATTCAGAGATT
AGACAAAAACTGAGAAAGTTGTACGGCTCTCCAGGTGACATTGACCTCTGGCCCGCCCTT
ATGGTTGAAGACCTGATTCCTGGTACAAGAGTGGGACCAACACTTATGTGCCTGTTTGTT
ACCCAGTTTCAGCGGCTAAGAGATGGAGATAGGTTCTGGTATGAAAACCCTGGAGTATTT
ACCCCGGCACAACTCACTCAGCTGAAGCAGGCGTCCCTGAGCCGGGTGCTTTGTGACAAT
GGTGACAGCATTCAGCAAGTGCAGGCTGATGTCTTTGTAAAGGCAGAATACCCACAGGAT
TACCTGAACTGCAGCGAGATCCCGAAGGTGGACCTGCGAGTGTGGCAAGACTGCTGTGCA
GACTGTAGGAGTAGAGGACAGTTCAGAGCAGTGACGCAAGAGTCTCAAAAGAAACGCTCA
GCTCAATACAGCTATCCTGTTGATAAGGATATGGAGTTAAGTCATCTAAGAAGTAGGCAA
CAAGATAAAATATATGTGGGTGAAGATGCTAGAAATGTGACAGTTCTGGCAAAAACAAAG
TTCTCCCAAGATTTCAGCACGTTTGCAGCGGAAATTCAGGAAACCATCACAGCACTCAGA
GAGCAGATAAACAAGCTGGAGGCACGCCTGAGGCAGGCAGGGTGTACAGATGTTAGAGGG
GTTCCAAGGAAGGCCGAGGAGCGCTGGATGAAAGAAGACTGCACTCACTGCATTTGTGAG
AGTGGCCAGGTCACCTGTGTGGTGGAGATTTGTCCCCCGGCTCCCTGTCCCAGTCCTGAA
TTGGTGAAAGGAACCTGCTGTCCAGTTTGCAGAGACCGAGGAATGCCAAGTGATTCCCCA
GAGAAGCGCTAA

Protein Properties

Number of Residues

1463

Molecular Weight

163652.53

Theoretical pI

7.437

Pfam Domain Function

An_peroxidase (PF03098 )
I-set (PF07679 )
VWC (PF00093 )
LRR_1 (PF00560 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Peroxidasin-like protein
MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFN
RIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKG
LISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSN
ALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEP
QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ
GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL
ITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ
FTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ
HDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQP
IITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI
QGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMAR
AGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSN
RCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPP
RLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP
PCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVY
GSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHR
ANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPK
VLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLP
FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAAT
IIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPAL
MVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDN
GDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRS
AQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALR
EQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPE
LVKGTCCPVCRDRGMPSDSPEKR

External Links

GenBank ID Protein

126517478

UniProtKB/Swiss-Prot ID

A1KZ92

UniProtKB/Swiss-Prot Entry Name

PXDNL_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [PubMed:16421571 ]
Cheng G, Salerno JC, Cao Z, Pagano PJ, Lambeth JD: Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med. 2008 Dec 15;45(12):1682-94. doi: 10.1016/j.freeradbiomed.2008.09.009. Epub 2008 Sep 23. [PubMed:18929642 ]