Human Metabolome Database: Showing Protein Serine/threonine-protein phosphatase with EF-hands 2 (HMDBP07952)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 metabolites

Identification

HMDB Protein ID

HMDBP07952

Secondary Accession Numbers

13663

Name

Serine/threonine-protein phosphatase with EF-hands 2

Synonyms

PPEF-2

Gene Name

PPEF2

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.

Pathways

Not Available

Reactions

A phosphoprotein + Water → a protein + Phosphate

details

GO Classification

Biological Process
negative regulation of MAPK cascade
detection of stimulus involved in sensory perception
negative regulation of peptidyl-threonine phosphorylation
protein dephosphorylation
regulation of JUN kinase activity
visual perception
Cellular Component
photoreceptor outer segment
photoreceptor inner segment
cytoplasm
Function
cation binding
protein serine/threonine phosphatase activity
manganese ion binding
phosphoric ester hydrolase activity
ion binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
transition metal ion binding
iron ion binding
phosphatase activity
calcium ion binding
phosphoprotein phosphatase activity
Molecular Function
manganese ion binding
iron ion binding
calcium ion binding
protein serine/threonine phosphatase activity
Hsp70 protein binding
Hsp90 protein binding
Process
detection of stimulus involved in sensory perception
detection of stimulus
response to stimulus

Cellular Location

Cytoplasm (Probable)
Cell projection
cilium
photoreceptor outer segment
Photoreceptor inner segment

Gene Properties

Chromosome Location

Locus

4q21.1

SNPs

PPEF2

Gene Sequence

>2262 bp
ATGGGAAGCGGCACCTCCACCCAACATCATTTTGCTTTCCAGAATGCAGAGAGAGCCTTC
AAGGCAGCAGCCCTGATCCAGAGATGGTACCGGCGCTACGTGGCCCGCCTGGAGATGAGG
CGGCGTTGCACCTGGAGCATCTTCCAGTCTATAGAATATGCTGGGCAGCAAGACCAAGTC
AAGCTCCATGACTTCTTCAGCTATCTCATGGATCACTTCATCCCCAGCAGCCACAACGAC
AGGGACTTCCTGACCCGCATATTCACTGAGGACAGATTCGCCCAGGACTCCGAGATGAAG
AAATGCAGTGACTATGAATCCATAGAGGTACCCGACAGTTACACGGGGCCACGCCTCTCC
TTCCCACTCCTGCCTGACCATGCAACTGCCCTGGTAGAAGCATTCAGACTGAAACAACAG
CTCCATGCTCGCTACGTCTTGAACCTTTTGTATGAAACCAAGAAACATCTGGTACAGCTG
CCAAACATCAACCGGGTCTCAACCTGTTACAGTGAGGAGATCACAGTGTGTGGAGACTTA
CATGGCCAATTGGATGACTTAATCTTTATATTTTATAAGAATGGCCTCCCGTCGCCAGAA
CGGTCATATGTGTTCAACGGTGACTTTGTGGATCGAGGCAAGGATTCAGTAGAGATCCTG
ATGATTCTTTTTGCCTTCATGCTGGTTTACCCCAAAGAGTTCCATCTTAACAGAGGAAAC
CATGAGGACCATATGGTGAACTTACGATATGGCTTCACCAAGGAAGTGATGAATAAATAC
AAGGTACACGGGAAGGAAATACTAAGAACCCTGCAAGATGTTTTCTGTTGGCTTCCACTG
GCCACTCTGATAGATGAGAAAGTTCTAATTCTTCATGGTGGGGTGTCAGACATAACTGAT
CTGGAGCTTTTGGACAAAATAGAGAGGAGCAAGATAGTTTCCACCATGAGGTGCAAAACG
AGACAGAAGAGTGAGAAGCAGATGGAGGAGAAGAGAAGAGCCAACCAGAAGAGCTCTGCA
CAGGGACCCATCCCATGGTTTCTCCCCGAAAGCCGCTCTCTTCCCTCTTCGCCCCTTCGG
CTTGGCTCCTACAAGGCCCAGAAAACCAGCAGGTCCTCCAGCATCCCCTGCAGCGGTTCC
CTGGACGGGCGGGAGCTCTCCCGGCAGGTGCGGAGCTCCGTGGAACTGGAGCTAGAGCGG
TGCCGGCAGCAAGCAGGCCTCCTGGTGACCGGAGAGAAAGAGGAGCCCTCCCGCTCAGCC
TCAGAAGCAGACTCTGAAGCCGGAGAGCTGCGGAAGCCCACTCAGGAGGAGTGGAGGCAG
GTTGTAGATATCCTGTGGAGTGATCCCATGGCTCAAGAGGGCTGCAAGGCCAACACTATT
CGAGGAGGAGGCTGTTATTTTGGGCCTGATGTGACACAACAGTTGCTACAAAAATACAAC
ATGCAATTCCTGATCCGTTCACATGAATGCAAACCTGAAGGCTATGAATTCTGTCACAAC
CGCAAGGTATTAACAATCTTTTCTGCCTCCAACTACTATGAAGTTGGCAGCAACAGAGGG
GCCTATGTCAAACTGGGGCCAGCCCTGACCCCACATATTGTGCAGTATCAAGCTAACAAG
GTGACCCACACACTCACCATGAGGCAAAGGATTAGCAGAGTGGAGGAGTCGGCTCTGAGA
GCTCTGAGGGAGAAGCTGTTTGCTCATTCTTCAGATCTTCTCAGTGAATTTAAGAAGCAT
GATGCAGATAAAGTCGGTTTAATCACCTTGAGTGACTGGGCAGCAGCGGTGGAGTCTGTG
TTGCACCTAGGACTGCCATGGCGGATGCTGAGGCCACAGCTGGTGAACAGCTCAGCAGAC
AACATGCTGGAGTACAAGTCTTGGCTGAAGAACTTGGCCAAGGAACAACTGAGTCGCGAG
AACATACAATCAAGTTTGCTGGAAACATTGTATCGAAACCGATCCAACCTAGAGACCATT
TTTAGGATCATAGACAGTGATCATTCAGGGTTCATCTCACTGGACGAGTTCAGGCAGACC
TGGAAGCTGTTCAGCTCTCACATGAATATCGACATTACAGATGACTGCATCTGTGACCTT
GCTCGGAGCATTGATTTCAACAAAGATGGCCACATTGATATCAATGAGTTCCTGGAGGCC
TTCCGCCTTGTGGAGAAATCCTGCCCAGAGGGCGATGCCTCAGAATGCCCACAAGCTACA
AATGCTAAAGACAGTGGCTGCAGCAGTCCAGGTGCACACTAA

Protein Properties

Number of Residues

753

Molecular Weight

86517.3

Theoretical pI

7.133

Pfam Domain Function

Metallophos (PF00149 )
efhand (PF00036 )
PPP5 (PF08321 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein phosphatase with EF-hands 2
MGSGTSTQHHFAFQNAERAFKAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQV
KLHDFFSYLMDHFIPSSHNDRDFLTRIFTEDRFAQDSEMKKCSDYESIEVPDSYTGPRLS
FPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDL
HGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGN
HEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITD
LELLDKIERSKIVSTMRCKTRQKSEKQMEEKRRANQKSSAQGPIPWFLPESRSLPSSPLR
LGSYKAQKTSRSSSIPCSGSLDGRELSRQVRSSVELELERCRQQAGLLVTGEKEEPSRSA
SEADSEAGELRKPTQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYN
MQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANK
VTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVGLITLSDWAAAVESV
LHLGLPWRMLRPQLVNSSADNMLEYKSWLKNLAKEQLSRENIQSSLLETLYRNRSNLETI
FRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKDGHIDINEFLEA
FRLVEKSCPEGDASECPQATNAKDSGCSSPGAH

External Links

GenBank ID Protein

23312386

UniProtKB/Swiss-Prot ID

O14830

UniProtKB/Swiss-Prot Entry Name

PPE2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J: Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11639-44. [PubMed:9326663 ]