Human Metabolome Database: Showing Protein Protocadherin gamma-C4 (HMDBP07930)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07930

Secondary Accession Numbers

13641

Name

Protocadherin gamma-C4

Synonyms

PCDH-gamma-C4

Gene Name

PCDHGC4

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cellular process
cell adhesion
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHGC4

Gene Sequence

>2817 bp
ATGCTCCGCAAGGTGAGAAGCTGGACAGAAATCTGGCGGTGGGCTACCCTTTTGTTCCTC
TTTTACCACCTGGGTTACGTTTGTGGGCAGATCCGCTACCCGGTCCCAGAGGAGTCACAG
GAAGGGACTTTTGTAGGGAATGTCGCTCAAGATTTCCTGCTGGATACGGACAGTCTGTCA
GCTCGCAGGCTGCAGGTCGCTGGAGAGGTGAACCAAAGACACTTCCGTGTGGATTTGGAC
AGCGGAGCCCTGCTCATCAAGAACCCAATCGACCGAGAGGCACTGTGTGGGCTCAGTGCC
AGCTGCATCGTGCCCCTGGAGTTTGTCACCGAAGGTCCTTTGGAAATGTACCGAGCAGAG
GTAGAGATCGTAGATGTGAATGATCACGCCCCCCGTTTTCCGCGGCAGCAGCTGGACTTG
GAAATTGGGGAGGCAGCTCCTCCAGGACAGCGTTTCCCGTTGGAAAAGGCTCAGGATGCA
GATGTGGGGAGCAATTCGATTAGCAGCTATAGGCTGAGCTCCAATGAACACTTTGCACTG
GATGTGAAGAAGCGCAGCGACGGCAGCCTGGTCCCAGAGCTGCTCCTGGAGAAGCCTTTG
GATCGAGAGAAGCAATCGGACTACCGCCTGGTGCTGACTGCTGTCGATGGAGGGAACCCG
CCGAGATCTGGCACCGCAGAGCTCCGGGTATCCGTGCTGGACGTAAACGACAACGCCCCA
GCCTTCCAGCAATCCAGCTACAGGATTAGTGTGTTGGAGAGCGCACCAGCGGGCATGGTG
CTCATCCAGCTCAATGCCTCAGACCCGGACCTGGGTCCCAGTGGTAACGTCACCTTTTAT
TTCAGTGGTCATACCCCTGATCGTGTAAGAAACCTCTTTAGCCTGCACCCCACTACTGGA
AAGCTTACTCTTTTGGGGCCCCTAGACTTTGAGAGTGAGAATTACTATGAATTTGATGTG
CGGGCTCGCGATGGGGGTTCTCCAGCCATGGAGCAACATTGCAGCCTTCGAGTGGATCTG
CTGGACGTAAATGACAATGCCCCTTACATCACAGTGACCTCAGAGCTTGGAACCCTCCCC
GAGAGTGCAGAACCTGGCACTGTGGTGGCACTTATCAGTGTGCAGGATCCAGACTCAGGG
TCAAACGGAGATGTGAGCCTCCGCATTCCTGACCACTTGCCATTTGCCCTCAAGTCTGCC
TTCAGGAACCAGTTCTCCCTGGTGACTGCTGGACCCTTGGATCGAGAGGCCAAATCTAGC
TATGACATCATGGTCACTGCTTCTGATGCTGGGAACCCTCCTCTCAGTACCCACAGAACT
ATTTTCCTCAATATTTCAGATGTGAATGATAATCCACCCTCTTTCTTTCAGAGGTCACAT
GAGGTGTTTGTTCCTGAGAACAATCGCCCAGGGGACCTGCTTTGCTCCCTTGCAGCCTCT
GACCCAGACTCTGGCTTGAATGCGCTTATCTCCTACTCACTCCTGGAGCCCAGGAATCGA
GATGTATCAGCTTCCTCTTTCATCTCTCTGAACCCCCAGACAGGAGCTGTTCATGCTACT
CGATCCTTTGACTATGAGCAAACCCAGACACTGCAGTTTGAGGTGCAGGCCCGGGATCGG
GGCAACCCACCCCTTAGCAGCACTGTAACAGTTCGTCTATTTGTGCTGGACCTCAATGAC
AATGCTCCAGCTGTGCTCCGTCCTCGGGCCCGGCCTGGTTCCTTATGTCCCCAAGCACTG
CCTCCATCAGTTGGTGCTGGCCACCTAATCACAAAGGTGACTGCTGTGGACTTGGATTCA
GGTTACAATGCTTGGGTTTCCTATCAGCTCCTGGAGGCCCCAGATCCCAGCCTGTTTGCA
GTCTCTCGATATGCTGGGGAGGTGCGGACGGCTGTTCCTATCCCAGCTGACCTCCCACCA
CAGAAGCTGGTCATTGTGGTAAAGGATAGTGGTAGTCCACCACTCTCTACCTCTGTTACT
CTCTTAGTGTCCTTAGAGGAAGACACTCATCCAGTTGTCCCAGATCTTCGAGAATCTTCA
GCTCCAAGGGAAGGAGAATCTCGTCTAACCCTCTACTTGGCTGTGTCCCTAGTGGCAATT
TGCTTTGTCTCCTTTGGCTCATTCGTGGCACTACTCTCTAAGTGTCTTCGTGGGGCAGCC
TGTGGAGTCACATGCTTTCCTGCTGGCACCTGTGCCTGTCTCACCAGATCTCGAAGGAGG
GAGGGGCTTCCCCCTTCCAATGGGATCCTCCGAATCCAGCTAGGGTCAGATGACCCTATC
AAGTTTGTTGATGTGGGAGGCCACTCTCATGGCTGTACACCCTTGGCTTCTGCACCCACT
CGGAGTGATAGCTTCATGATGGTGAAGTCACCCAGTGCACCTATGGCAGGGGAGCCTGTT
CGCCCAAGCTGCCCACCCTCTGATCTTCTCTATGGGCTAGAGCAAGCCCCGCCCAACACG
GACTGGCGTTTCTCTCAGGCCCAGAGACCCGGCACCAGCGGCTCCCAAAATGGCGATGAC
ACCGGCACCTGGCCCAACAACCAGTTTGACACAGAGATGCTGCAAGCCATGATCTTGGCG
TCCGCCAGTGAAGCTGCTGATGGGAGCTCCACCCTGGGAGGGGGTGCCGGCACCATGGGA
TTGAGCGCCCGCTACGGACCCCAGTTCACCCTGCAGCACGTGCCCGACTACCGCCAGAAT
GTCTACATCCCAGGCAGCAATGCCACACTGACCAACGCAGCTGGCAAGCGGGATGGCAAG
GCCCCAGCAGGTGGCAATGGCAACAAGAAGAAGTCGGGCAAGAAGGAGAAGAAGTAA

Protein Properties

Number of Residues

938

Molecular Weight

101212.6

Theoretical pI

4.97

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-29

Transmembrane Regions

693-713

Protein Sequence

>Protocadherin gamma-C4
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLS
ARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAE
VEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAP
AFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTG
KLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSS
YDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAAS
DPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDS
GYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVT
LLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPT
RSDSFMMVKSPSAPMAGEPVRPSCPPSDLLYGLEQAPPNTDWRFSQAQRPGTSGSQNGDD
TGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQN
VYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

External Links

GenBank ID Protein

5456982

UniProtKB/Swiss-Prot ID

Q9Y5F7

UniProtKB/Swiss-Prot Entry Name

PCDGL_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]