Human Metabolome Database: Showing Protein Protocadherin alpha-C2 (HMDBP07909)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07909

Secondary Accession Numbers

13620

Name

Protocadherin alpha-C2

Synonyms

PCDH-alpha-C2

Gene Name

PCDHAC2

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cellular process
cell adhesion
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHAC2

Gene Sequence

>3024 bp
ATGGAGCAGGCGGGCACCAGACCTGCGGCGACAGAGCATCCACGGCTCCGGCGGCCCATG
CCCTGGCTGCTGCTACTGCCTCTCCTGCTGCTGTTGCTGCTGCTGCTACCTGGCCCAGCG
GCCTCCCAGCTGCGATACTCTGTGCCAGAGGAGCAGGCACCCGGCGCGCTCGTGGGCAAC
GTGGCTCGCGCGCTGGGGCTTGAGCTGCGGCGCTTGGGGCCGGGTTGCTTGCGCATCAAC
CATCTGGGTGCGCCCAGTCCGCGCTACCTGGAGCTGGACCTGACGAGTGGAGCGCTCTTC
GTCAACGAGCGCATTGATCGGGAGGCGCTGTGTGAGCAGCGGCCTCGCTGCCTGCTCAGC
CTGGAAGTGCTGGCGCACAACCCCGTGGCGGTGAGCGCCGTTGAGGTGGAAATATTGGAC
ATCAACGACAACTCACCGCGTTTCCCGCGGCCCAACTACCAGCTTCAGGTAAGCGAATCG
GTGGCGCCTGGAGCGCGCTTTCACATAGAGAGTGCGCAGGACCCCGACGTGGGCGCCAAC
TCAGTACAGACCTACGAGCTCAGCCCCAGCGAGCACTTCGAGCTGGACCTTAAGCCCCTG
CAGGAGAACAGTAAAGTGCTTGAGCTGGTGCTGCGTAAGGGCCTAGACCGGGAGCAGGCA
GCCTTGCACCACCTGGTTCTCACAGCCGTGGATGGGGGCATTCCAGCCCGCTCGGGTACG
GCACAGATCTCTGTGCGTGTCCTGGACACTAACGACAACTCTCCTGCCTTTGACCAGTCC
ACTTATCGCGTCCAGCTACGGGAGGACTCACCCCCAGGCACATTGGTGGTGAAGCTGAAT
GCCTCAGACCCGGATGAGGGCTCCAATGGTGAGCTCAGGTACTCCTTGAGCAGCTACACG
TCGGACCGGGAGAGGCAGCTCTTCAGCATAGATGCCAGTACCGGGGAAGTGCGAGTAATT
GGGGGGCTGGATTATGAGGAAGCCTCCTCCTACCAGATCTATGTGCAGGCGACTGACCGG
GGTCCAGTGCCCATGGCAGGTCACTGCAAGGTGCTGGTGGACATCGTGGACGTGAATGAC
AATGCCCCAGAGGTGGTGCTCACGGACCTGTATAGCCCAGTGCCTGAGAATGCTACACCC
AACACCATTGTGGCCGTTCTCAGTGTCAATGACCAAGACTCAGGCCCCAACCGGAAAGTG
AGCCTGGGTCTGGAGGCCACACTGCCTTTCCGACTGAATGGCTTTGGAAACTCCTATACA
CTGGTGGTGAGCGGCCCACTGGACCGAGAGCGGGTGGCTGTCTACAACATCACGGTGACA
GCCACAGATGGGGGAATACCGCAGCTCACATCCCTGCGTACACTGAAGGTTGAGATCTCT
GACATCAATGACAATCCACCAAGCTTCCTGGAGGACTCCTATTCCATCTACATACAGGAG
AACAATTTGCCAGGTGTGTTGCTCTGTACTGTGCAAGCCACAGACCCAGATGAAAAGGAG
AATGCAGAGGTGACCTACTCCCTTCTGGAGAGGGAGATTCAAGGGCTGCCAGTCACCTCC
TATGTCTCCATTAACAGTGCCAGTGGCAGCCTTTATGCTGTCAACTCCTTTGACTATGAG
AAGTTTCGGGAGTTCTTTGTGACTGTGGAGGCTCAGGACAAGGGGAGCCCACCACTGAGC
AGCACTGTGACTGCCAACGTATATGTGGTGGACATGAATGACCATGCCCCTCACATTCTG
TACCCTACCTCAACCAACTCGTCAGCAGCCTTCGAGATGGTGCCTCGAACTGCCCCTGCT
GGCTACCTGGTCACCAAAGTCATAGCTATGGACTCAGACTCTGGGCAAAATGCTTGGCTT
TTTTACCATCTAGCCCAGACTTCTGACCTGGACCTCTTTAAGGTAGAGCTGCACACAGGA
GAAATTAGGACTACCAGGAAGATGGGAGATGAGAGTGGTAGCACTTTCAACCTGACCGTG
GTGGTCCGAGATAATGGAGAGCCATCACTATCAGCCTCTGTGGCCATTACAGTAGCTGTG
GTGGATAGGGTTTCCAAAATCCTCCCTGACACTCAGAGGCATGTTAAGAGCCCTCGGACA
TACTCTGAAATTACCCTTTATCTAATAATAGCATTAAGCACAGTGTCTTTTATATTTCTT
TTGACAATCATCATTTTGAGCATCATCAAGTGCTACCGCTACACTGCGTATGGCACTGCA
TGCTGTGGAGGCTTCTGTGGAGTAAGGGAAAGGTCCCCTGCAGAACTGTACAAACAAGCC
AACAACAATATTGATGCCAGGATACCGCATGGCCTCAAAGTGCAGCCTCACTTCATTGAA
GTTCGAGGGAATGGCTCCCTCACCAAGACCTACTGCTACAAGGCCTGTCTGACAGCAGGC
TCAGGGAGTGACACTTTCATGTTTTACAATACAGGGGCCCAGACAGGACCAGGGCCTTCG
GGAGCCCAAGCAGCAGTGACTGACAGCAGGAATCTCACAGGCCAAAGTGGTCAGAATGCT
GGGAACCTGATTATTCTCAAAAATGAGGCTGTTTCTCAAAATGAGCCACGACAGCCCAAC
CCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTGCACCTAGAG
GAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCAACAGTATCC
AGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAAC
AGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAG
TTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAGCCT
ACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAG
AAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGGGAACAGC
ACGACTGACAACAGTGACCAGTGA

Protein Properties

Number of Residues

1007

Molecular Weight

109449.0

Theoretical pI

5.07

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-42

Transmembrane Regions

709-729

Protein Sequence

>Protocadherin alpha-C2
MEQAGTRPAATEHPRLRRPMPWLLLLPLLLLLLLLLPGPAASQLRYSVPEEQAPGALVGN
VARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLS
LEVLAHNPVAVSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGAN
SVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGT
AQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYT
SDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVND
NAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYT
LVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQE
NNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYE
KFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPA
GYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTV
VVRDNGEPSLSASVAITVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFL
LTIIILSIIKCYRYTAYGTACCGGFCGVRERSPAELYKQANNNIDARIPHGLKVQPHFIE
VRGNGSLTKTYCYKACLTAGSGSDTFMFYNTGAQTGPGPSGAQAAVTDSRNLTGQSGQNA
GNLIILKNEAVSQNEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVS
SATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEP
TNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

External Links

GenBank ID Protein

5456894

UniProtKB/Swiss-Prot ID

Q9Y5I4

UniProtKB/Swiss-Prot Entry Name

PCDC2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]