Human Metabolome Database: Showing Protein Protocadherin beta-12 (HMDBP07902)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07902

Secondary Accession Numbers

13613

Name

Protocadherin beta-12

Synonyms

PCDH-beta-12

Gene Name

PCDHB12

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cellular process
cell adhesion
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHB12

Gene Sequence

>2388 bp
ATGGAAAACGGAGGGGCAGGCACTCTGCAGATAAGGCAAGTCCTGCTTTTCTTTGTTTTG
CTGGGAATGTCTCAGGCGGGCTCTGAAACTGGGAACTTTTTGGTGATGGAGGAATTGCAG
AGCGGGAGCTTTGTAGGAAATTTGGCAAAGACCCTGGGACTCGAGGTGAGTGAGCTGTCT
TCGCGGGGGGCTCGGGTGGTTTCTAATGATAACAAAGAGTGTTTGCAGCTGGACACAAAC
ACTGGGGATTTGCTCCTGAGAGAAATGCTAGACAGGGAGGAGCTCTGTGGCTCCAATGAG
CCTTGTGTGCTGTATTTCCAAGTGTTAATGAAAAACCCCACGCAGTTTTTACAAATTGAG
CTCCAGGTCAGGGATATAAATGATCACTCTCCCGTCTTCTTGGAAAAAGAAATGCTCTTA
GAAATCCCAGAGAACAGTCCTGTTGGTGCTGTGTTCTTGCTTGAAAGTGCAAAGGATTTA
GATGTAGGAATCAATGCTGTAAAAAGCTACACAATAAATCCGAACTCTCATTTCCACGTT
AAAATAAGAGTCAATCCAGACAATAGGAAATACCCTGAGTTAGTTCTGGACAAGGCGCTG
GATTATGAAGAGCGCCCGGAGCTCAGTTTCATCCTCACTGCTCTGGATGGCGGGTCCCCT
CCCAGGTCTGGAACTGCCTTGGTCAGGGTGGTGGTTGTAGATATTAATGACAACTCCCCT
GAGTTTGAGCAGGCTTTTTATGAGGTGAAGATTCTGGAGAATAGCATCCTTGGCTCCCTG
GTTGTGACCGTCTCAGCCTGGGATTTAGACTCTGGAACAAACAGTGAACTATCCTATACC
TTTTCCCATGCCTCAGAAGATATTCGCAAGACATTTGAAATTAATCAAAAGTCTGGTGAC
ATTACTTTAACAGCACCTTTGGATTTTGAAGCAATTGAGTCATACTCAATAATCATTCAA
GCCACAGATGGGGGAGGACTTTTTGGAAAATCTACAGTCAGAATTCAGGTGATGGATGTA
AACGACAACGCTCCTGAAATCACTGTGTCATCAATTACCAGTCCAATCCCAGAAAACACT
CCAGAGACTGTGGTTATGGTTTTCAGGATACGAGACAGAGACTCTGGGGACAACGGAAAG
ATGGTTTGTTCTATCCCGGAGGACATCCCATTCGTGCTAAAATCTTCGGTAAATAATTAC
TACACTTTGGAAACAGAGAGACCGCTGGACAGAGAGAGCAGAGCCGAGTACAACATCACC
ATCACCGTCACCGACTTGGGGACCCCCAGGCTAAAAACCGAGCACAACATAACCGTGCTG
GTCTCCGACGTCAATGACAACGCCCCCGCCTTCACCCAAACTTCCTACGCCCTGTTCGTC
CGCGAGAACAACAGCCCCGCCCTGCACATCGGCAGCATCAGCGCCACAGACAGAGACTCG
GGCACCAACGCCCAGGTCAACTACTCGCTGCTGCCGTCCCAGGACCCGCACCTGCCCCTC
GCCTCCCTGGTCTCCATCAACGCGGACAACGGCCACCTGTTTGCCCTCAGGTCGCTGGAC
TACGAGGCCCTGCAGGGGTTCCAGTTCCGCGTGGGCGCCACAGACCACGGCTCCCCGGCT
TTGAGCAGCGAGGCGCTGGTGCGCGTGCTGGTGCTGGACGCCAACGACAACTCGCCCTTC
GTGCTGTACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCTGGGCGGCC
GAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGTGACTCGGGCCAGAACGCC
TGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTATTCGGCGTGTGGGCGCAC
AATGGCGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGCGGCCAAGCACAGGCTG
GTGGTGCTGGTCAAGGACAATGGCGAGCCTCCGCGCTCGGCCACCGCCACGCTGCACGTG
CTCCTGGTGGACGGCTTCTCCCAGCCCTACCTGCCTCTCCCGGAGGCGGCCCCGGCCCAG
GCCCAGGCCGACTCGCTCACTGTCTACCTGGTGGTGGCGTTGGCCTCAGTGTCGTCGCTC
TTCCTCTTCTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGGGCGGCC
CCGGTCGGTCGCTGCTCGGTGCCTGAGGGCCCCTTTCCAGGACATCTGGTGGACGTGAGT
GGCACCGGGACCCTGTCCCAGAGCTACCACTATGAGGTGTGTGTGACTGGAGGCTCCAGG
TCAAATAAGTTCAAATTTCTGAAACCAATTATCCCCAACTTCCTACCCCAGAGCACAGGT
AGTGAAGTCGAAGAAAATCCCCCATTTCAGAATAATTTGGGTTTCTGA

Protein Properties

Number of Residues

795

Molecular Weight

86769.0

Theoretical pI

4.46

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-26

Transmembrane Regions

691-711

Protein Sequence

>Protocadherin beta-12
MENGGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGLEVSELS
SRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIE
LQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHFHV
KIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSP
EFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGD
ITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITVSSITSPIPENT
PETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNIT
ITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRDS
GTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPA
LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNA
WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV
LLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAA
PVGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTG
SEVEENPPFQNNLGF

External Links

GenBank ID Protein

5457031

UniProtKB/Swiss-Prot ID

Q9Y5F1

UniProtKB/Swiss-Prot Entry Name

PCDBC_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]