Human Metabolome Database: Showing Protein Protocadherin beta-1 (HMDBP07891)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07891

Secondary Accession Numbers

13602

Name

Protocadherin beta-1

Synonyms

PCDH-beta-1

Gene Name

PCDHB1

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cellular process
cell adhesion
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHB1

Gene Sequence

>2457 bp
ATGGCGGGTACGCGCAGAAAATCTTTGCAAAACAGGCAAGTGGGATCTCTTCTCATTTTT
CTGTGCATATCTGTGGGGGATGCGACAACTATCCGCTATTCAGTGGCAGAGGAAATGGAG
AGCGGCTCGTTTGTGGCCAACGTAGCTAAGGACCTAGGACTGGAGGTAGGGAAGCTGGCT
GCGCGCGGGGCGCGGCTGGTTTCCGAGGGCAACAAAATGCATTTCCGGCTCCACCGCAAG
ACGGGAGATTTGTTTGTGAAGGAGAAACTGGATCGGGAGTCACTTTGTGGCAAAGCCGAC
CCTTGTGTTCTGCACTTTGAAGTAGTCCTGGTGGAGCCGCTGCAGTCCTTCCGGGCCGAG
GTCAGGGTATTTGATATCAATGACAATGCCCCAGTTTTCCTAAACAAGGAGCCGCTTTTA
AAGATTCCGGAGAGCACCCCTTTGGGTTCACGTTTTCCTCTGCAGAGCGCCCAGGATCTG
GACGTGGGCCTTAACGGTCTCCAGAACTACACCCTGAGTGCCAATGGGTATTTCCACCTG
CACACCCGCTTCTGCAGCCACGGGCCTAAATATGCTGAGCTGGTGCTGAACAAACCCCTG
GACCGAGAGGAGCAGCCTGAAGTCAACTTGACAATTACGGCGGTGGACGGCGGGTCCCCG
CCTAAGTCTGGCACAGCTCACATCCACGTGGTGGTTCTGGATGTCAACGACCACGTGCCC
CAGTTCTCGCGACTGGTGTACAGAGCCCAGGTATCAGAGAACAGCCCCAATGGCTCTTTG
GTGGCCACGGTGACTGCCGTGGACCTAGACGAGGGCACCAACAAAGCGATAACTTACTCT
TTAGCTCAAAACCCAGAAGCAATTCTCAAGACGTTTCAGATTGACCCTCAAAATGGAGAA
GTTCGACTAAGAGGACCCCTCGATTTTGAAGCCATTGAAACATACGACATTGACATTCAA
GCTACAGATGGTGGAGGCCTCTCTGCCCACAGCAAAGTCCTGGTAGAAGTGGTGGATGTG
AATGACAATCCTCCCGAAGTGATGGTCTCCTCTGTGTCCAGCCCACTCCCTGAAGACTCA
CCACCACAGACAGTAGTAGCCCTTTTCACTATCAGAGACCGGGACATTCGAGTGGGAGGA
AAAGTCACCTGCTTCCTCAGAGAAGACCTTCCCTTTGTAATCAAACCTACATTTGGGAAT
TCTTACTCACTGGTCACTGACAGAAGCTTGGATCGGGAGGAGGTCTCAGGCTATAATATC
ACCATTGTTGCCATGGATACTGGACCACCTAGCTTGTCTGCCGAGACTATGATAGAGGTG
CTAATATCCGACGTTAATGACAATCCTCCAATATTTCGGGAAGATTCCTATATCTTGACT
GTTCGAGAAAACAACAGTCCTGCGGTTTTTATTGGCAAAGTCCATGCTGAGGATCTTGAT
TTGGGTGAGAATGCCCAAATAACATATTCTCTGTTGCCTCCAAAAAACGGAGATCTTTCA
GTCTTTGCTTACATATCCATAAATTCAGGCAATGGGAAGCTCTACGCGCTGAGAACCATG
GATTATGAGGCCATTCAAGATTTTCAATTTGTGGTAAAGGCAACTGATGGGGGCTTCCTG
TCACTGAGTAGCCAAGTTACTGTCAGAGTGGTTGTCCTAGATGACAATGACAATCGTCCA
ATGATCTTATACCCACTGCAGAACGGCACCTTGCCCTGCAATGACCTGGTGCCCAGGTCT
GCAGAGGCAGGCTACCTAGTGACCAAAGTGGTGGCTGTGGATGGTGACTCAGGTCAGAAT
TCTTGGCTTTCATATCATCTACTTAAGGCCACTGACCTTGGGTTATTTTCTGTTCAAAGA
CAAAATGGAGAAATCCATACATTAAGGCAGATATCTGAGAGAGACCCCATGATGCAGAAA
TTGATCATTCTTGTTCAGGATCACGGCCAACCAGCTCTTTCCACTACTGTCTCACTCAAC
ATCCTGCTGGTAGATGGCTTTTCAGAGCCCTACCTGCAGTTCCAGGATCCAACCAAGCAT
TCTAGAAAGGTAAATCCATCCACTAAATATTTGGTCATTTCTCTGGTCATCCTTTCCTTT
CTCTTTCTCCTCTCTGTCATAGTGATCTTCATTATACATGTCTACCAAAAGATTAAATAT
AGAGAAAAGTTCACAATTCAAGAGCATTTCTATGATGACTGTAATTTCTCTAACAACCTG
GTACAAGGACAAGGCAATGGATCCTTATCTCGGCCTTGTCCATATGAAATGTGTTCAGCC
ACTGGCACTGGTAATAGTGAGTTTCGCTTTCTTAAGCGTTTTATGCCCAACTTGCCTTTC
CCTCATGCCACTGGGGAGATAAAAATGGAGGCTGGCTCCAGTTTGCCCCCAAATTCTGAT
AGGAATAAGTCTCAGAGATTAGAGGGCCATGACCAGGTATCTGATGACTATATGTAG

Protein Properties

Number of Residues

818

Molecular Weight

90489.8

Theoretical pI

5.03

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-28

Transmembrane Regions

692-712

Protein Sequence

>Protocadherin beta-1
MAGTRRKSLQNRQVGSLLIFLCISVGDATTIRYSVAEEMESGSFVANVAKDLGLEVGKLA
ARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRAE
VRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHL
HTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVP
QFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGE
VRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDS
PPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNI
TIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLD
LGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFL
SLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQN
SWLSYHLLKATDLGLFSVQRQNGEIHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLN
ILLVDGFSEPYLQFQDPTKHSRKVNPSTKYLVISLVILSFLFLLSVIVIFIIHVYQKIKY
REKFTIQEHFYDDCNFSNNLVQGQGNGSLSRPCPYEMCSATGTGNSEFRFLKRFMPNFPF
PHATGEIKMEAGSSLPPNSDRNKSQRLEGHDQVSDDYM

External Links

GenBank ID Protein

5457025

UniProtKB/Swiss-Prot ID

Q9Y5F3

UniProtKB/Swiss-Prot Entry Name

PCDB1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]