Human Metabolome Database: Showing Protein Protocadherin-10 (HMDBP07868)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07868

Secondary Accession Numbers

13579

Name

Protocadherin-10

Synonyms

Not Available

Gene Name

PCDH10

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cellular process
cell adhesion
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:4

Locus

4q28.3

SNPs

PCDH10

Gene Sequence

>3123 bp
ATGATTGTGCTATTATTGTTTGCCTTGCTCTGGATGGTGGAAGGAGTCTTTTCCCAGCTT
CACTACACGGTACAGGAGGAGCAGGAACATGGCACTTTCGTGGGGAATATCGCTGAAGAT
CTGGGTCTGGACATTACAAAACTTTCGGCTCGCGGGTTTCAGACGGTGCCCAACTCAAGG
ACCCCTTACTTAGACCTCAACCTGGAGACAGGGGTGCTGTACGTGAACGAGAAAATAGAC
CGCGAACAAATCTGCAAACAGAGCCCCTCCTGTGTCCTGCACCTGGAGGTCTTTCTGGAG
AACCCCCTGGAGCTGTTCCAGGTGGAGATCGAGGTGCTGGACATTAATGACAACCCCCCC
TCTTTCCCGGAGCCAGACCTGACGGTGGAAATCTCTGAGAGCGCCACGCCAGGCACTCGC
TTCCCCTTGGAGAGCGCATTCGACCCAGACGTGGGCACCAACTCCTTGCGCGACTACGAG
ATCACCCCCAACAGCTACTTCTCCCTGGACGTGCAGACCCAGGGGGATGGCAACCGATTC
GCTGAGCTGGTGCTGGAGAAGCCACTGGACCGAGAGCAGCAAGCGGTGCACCGCTACGTG
CTGACCGCGGTGGACGGAGGAGGTGGGGGAGGAGTAGGAGAAGGAGGGGGAGGTGGCGGG
GGAGCAGGCCTGCCCCCCCAGCAGCAGCGCACCGGCACGGCCCTACTCACCATCCGAGTG
CTGGACTCCAATGACAATGTGCCCGCTTTCGACCAACCCGTCTACACTGTGTCCCTACCA
GAGAACTCTCCCCCAGGCACTCTCGTGATCCAGCTCAACGCCACCGACCCGGACGAGGGC
CAGAACGGTGAGGTCGTGTACTCCTTCAGCAGCCACATTTCGCCCCGGGCGCGGGAGCTT
TTCGGACTCTCGCCGCGCACTGGCAGACTGGAGGTAAGCGGCGAGTTGGACTATGAAGAG
AGCCCAGTGTACCAAGTGTACGTGCAAGCCAAGGACCTGGGCCCCAACGCCGTGCCTGCG
CACTGCAAGGTGCTAGTGCGAGTACTGGATGCTAATGACAACGCGCCAGAGATCAGCTTC
AGCACCGTGAAGGAAGCGGTGAGTGAGGGCGCGGCGCCCGGCACTGTGGTGGCCCTTTTC
AGCGTGACTGACCGCGACTCAGAGGAGAATGGGCAGGTGCAGTGCGAGCTACTGGGAGAC
GTGCCTTTCCGCCTCAAGTCTTCCTTTAAGAATTACTACACCATCGTTACCGAAGCCCCC
CTGGACCGAGAGGCGGGGGACTCCTACACCCTGACTGTAGTGGCTCGGGACCGGGGCGAG
CCTGCGCTCTCCACCAGTAAGTCGATCCAGGTACAAGTGTCGGATGTGAACGACAACGCG
CCGCGTTTCAGCCAGCCGGTCTACGACGTGTATGTGACTGAAAACAACGTGCCTGGCGCC
TACATCTACGCGGTGAGCGCCACCGACCGGGATGAGGGCGCCAACGCCCAGCTTGCCTAC
TCTATCCTCGAGTGCCAGATCCAGGGCATGAGCGTCTTCACCTACGTTTCTATCAACTCT
GAGAACGGCTACTTGTACGCCCTGCGCTCCTTCGACTATGAGCAGCTGAAGGACTTCAGT
TTTCAGGTGGAAGCCCGGGACGCTGGCAGCCCCCAGGCGCTGGCTGGTAACGCCACTGTC
AACATCCTCATAGTGGATCAAAATGACAACGCCCCTGCCATCGTGGCGCCTCTACCAGGG
CGCAACGGGACTCCAGCGCGTGAGGTGCTGCCCCGCTCGGCGGAGCCGGGTTACCTGCTC
ACCCGCGTGGCCGCCGTGGACGCGGACGACGGCGAGAACGCCCGGCTCACTTACAGCATC
GTGCGTGGCAACGAAATGAACCTCTTTCGCATGGACTGGCGCACCGGGGAGCTGCGCACA
GCACGCCGAGTCCCGGCCAAGCGCGACCCCCAGCGGCCTTATGAGCTGGTGATCGAGGTG
CGCGACCATGGGCAGCCGCCCCTTTCCTCCACCGCCACCCTGGTGGTTCAGCTGGTGGAT
GGCGCCGTGGAGCCCCAGGGCGGGGGCGGGAGCGGAGGCGGAGGGTCAGGAGAGCACCAG
CGCCCCAGTCGCTCTGGCGGCGGGGAAACCTCGCTAGACCTCACCCTCATCCTCATCATC
GCGTTGGGCTCGGTGTCCTTCATCTTCCTGCTGGCCATGATCGTGCTGGCCGTGCGTTGC
CAAAAAGAGAAGAAGCTCAACATCTATACTTGTCTGGCCAGCGATTGCTGCCTCTGCTGC
TGCTGCTGCGGTGGCGGAGGTTCGACCTGCTGTGGCCGCCAAGCCCGGGCGCGCAAGAAG
AAACTCAGCAAGTCAGACATCATGCTGGTGCAGAGCTCCAATGTACCCAGTAACCCGGCC
CAGGTGCCGATAGAGGAGTCCGGGGGCTTTGGCTCCCACCACCACAACCAGAATTACTGC
TATCAGGTATGCCTGACCCCTGAGTCCGCCAAGACCGACCTGATGTTTCTTAAGCCCTGC
AGCCCTTCGCGGAGTACGGACACTGAGCACAACCCCTGCGGGGCCATCGTCACCGGTTAC
ACCGACCAGCAGCCTGATATCATCTCCAACGGAAGCATTTTGTCCAACGAGACTAAACAC
CAGCGAGCAGAGCTCAGCTATCTAGTTGACAGACCTCGCCGAGTTAACAGTTCTGCATTC
CAGGAAGCCGACATAGTAAGCTCTAAGGACAGTGGTCATGGAGACAGTGAACAGGGAGAT
AGTGATCATGATGCCACCAACCGTGCCCAGTCAGCTGGTATGGATCTCTTCTCCAATTGC
ACTGAGGAATGTAAAGCTCTGGGCCACTCAGATCGGTGCTGGATGCCTTCTTTTGTCCCT
TCTGATGGACGCCAGGCTGCTGATTATCGCAGCAATCTGCATGTTCCTGGCATGGACTCT
GTTCCAGACACTGAGGTGTTTGAAACTCCAGAAGCCCAGCCTGGGGCAGAGCGGTCCTTT
TCCACCTTTGGCAAAGAGAAGGCCCTTCACAGCACTCTGGAGAGGAAGGAGCTGGATGGA
CTGCTGACTAATACGCGAGCGCCTTACAAACCACCATATTTGACACGGAAAAGGATATGC
TAG

Protein Properties

Number of Residues

1040

Molecular Weight

112934.9

Theoretical pI

4.49

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-18

Transmembrane Regions

716-736

Protein Sequence

>Protocadherin-10
MIVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSR
TPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPP
SFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRF
AELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRV
LDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRAREL
FGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISF
STVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAP
LDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGA
YIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFS
FQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLL
TRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARRVPAKRDPQRPYELVIEV
RDHGQPPLSSTATLVVQLVDGAVEPQGGGGSGGGGSGEHQRPSRSGGGETSLDLTLILII
ALGSVSFIFLLAMIVLAVRCQKEKKLNIYTCLASDCCLCCCCCGGGGSTCCGRQARARKK
KLSKSDIMLVQSSNVPSNPAQVPIEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPC
SPSRSTDTEHNPCGAIVTGYTDQQPDIISNGSILSNETKHQRAELSYLVDRPRRVNSSAF
QEADIVSSKDSGHGDSEQGDSDHDATNRAQSAGMDLFSNCTEECKALGHSDRCWMPSFVP
SDGRQAADYRSNLHVPGMDSVPDTEVFETPEAQPGAERSFSTFGKEKALHSTLERKELDG
LLTNTRAPYKPPYLTRKRIC

External Links

GenBank ID Protein

14589916

UniProtKB/Swiss-Prot ID

Q9P2E7

UniProtKB/Swiss-Prot Entry Name

PCD10_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [PubMed:10718198 ]
Wolverton T, Lalande M: Identification and characterization of three members of a novel subclass of protocadherins. Genomics. 2001 Aug;76(1-3):66-72. [PubMed:11549318 ]